DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and KRT79

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_787028.1	Gene:	KRT79 / 338785	HGNCID:	28930	Length:	535	Species:	Homo sapiens

Alignment Length:	460	Identity:	113/460 - (24%)
Similarity:	207/460 - (45%)	Gaps:	101/460 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDT-----VNRETSNLKAVYEKELAA 102
            |.||:|:::.||::.|.:||::|.||.:|..|..:..|.|:.     |.|  :||:.::|..|.:
Human   139 RTQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGQNLGVTR--NNLEPLFEAYLGS 201

  Fly   103 ARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRY-NEVNGKYNQS 166
            .|..||....|:.:|:.:::.:.:..:|.|                     |:| :|:|
Human   202 MRSTLDRLQSERGRLDSELRNVQDLVEDFK---------------------NKYEDEIN------ 239

  Fly   167 LADRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELT 231
                       |..|.|||.:     .|:|.::|..:.|:||..:..:|.:|:.|..|::..||:
Human   240 -----------KHTAAENEFV-----VLKKDVDAAYMGRMDLHGKVGTLTQEIDFLQQLYEMELS 288

  Fly   232 ETR-------------SRRQIEISEIDGRLSRQYEAKLQQSLQELRDQYEGQMRINREEIELLYD 283
            :.:             :.|.:::..|...:..|||...|:|..|....|:.:.    ||:::...
Human   289 QVQTHVSNTNVVLSMDNNRNLDLDSIIAEVKAQYELIAQRSRAEAEAWYQTKY----EELQVTAG 349

  Fly   284 NEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQR 348
            ....||:...|..|:    .|..::.::.:.|....:.|.|:...|....| .||. |.|.:::
Human   350 KHGDNLRDTKNEIAE----LTRTIQRLQGEADAAKKQCQQLQTAIAEAEQR-GELA-LKDAQKK- 407

  Fly   349 HNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTD 413
                :..|:..|.:.::::...|::||.||::|::||:|||.|.|||..||.|::.|.|...:
Human   408 ----LGDLDVALHQAKEDLTRLLRDYQELMNVKLALDVEIATYRKLLESEESRMSGECPSAVS-- 466

  Fly   414 SGISSNGSHLT---ASASSRSGRVTPSGRRSATPG---------------ISGSSAVKRRRTVID 460
              ||..|:..|   ..|:|..|.::..|...||.|               :|..:::.|:.|.:.
Human   467 --ISVTGNSTTVCGGGAASFGGGISLGGSGGATKGGFSTNVGYSTVKGGPVSAGTSILRKTTTVK 529

  Fly   461 ESEDR 465
            .|..|
Human   530 TSSQR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	93/374 (25%)
		ATP-synt_B	<67..>142	CDD:304375	19/79 (24%)
		MreC	<178..>224	CDD:302802	14/45 (31%)
		LTD	473..574	CDD:279300
KRT79	NP_787028.1	Head	1..141		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		Keratin_2_head	30..138	CDD:292825
		Filament	141..456	CDD:278467	93/374 (25%)
		Coil 1A	142..177		12/34 (35%)
		Linker 1	178..198		6/21 (29%)
		Coil 1B	199..290		29/133 (22%)
		Linker 12	291..314		1/22 (5%)
		Coil 2	315..453		40/152 (26%)
		Tail	454..535		20/85 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910