DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LamC and Lam

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster

Alignment Length:	604	Identity:	317/604 - (52%)
Similarity:	417/604 - (69%)	Gaps:	55/604 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LNTRVSRASTSTPVGG----------------ASTSSRVGATSPTSPTRTSRQQEKEELQHLNDR 56
            ::::..||.|:||..|                .||.|:. |:||.||||.||..||.|||:||||
  Fly     1 MSSKSRRAGTATPQPGNTSTPRPPSAGPQPPPPSTHSQT-ASSPLSPTRHSRVAEKVELQNLNDR 64

  Fly    57 LACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDI 121
            ||.||||:||||.||||||.|:...:|||.|||:|:|.::|.||...|:|||:||:::|:.||||
  Fly    65 LATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDI 129

  Fly   122 KRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENER 186
            |||||||::||.:|||||||.|.||.|.|:||:|.||:|.||||:.|||||..:...|...|.||
  Fly   130 KRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELER 194

  Fly   187 LRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQ 251
            ||:|.::.||.||.|||:||||||..|||||||:||||:|:||:.|:|..:|.|.||||||||.:
  Fly   195 LRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSE 259

  Fly   252 YEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDG 316
            |:|||:|||||||.|||.||:|||:||:.||:::||.|:.||.|.:..:..:.||:|..|.:||.
  Fly   260 YDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDA 324

  Fly   317 LNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIK 381
            |||.:..||..||.||||||:||..||.:|:||.|.|..||.||.|:|:||..||:|||.|||||
  Fly   325 LNANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIK 389

  Fly   382 VSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNGSHLTASASS------RSGRVTPSGRR 440
            ||||||||||||||.|||.||||    .|.|:          ||:..|      .|.|.|||.|
  Fly   390 VSLDLEIAAYDKLLVGEEARLNI----TPATN----------TATVQSFSQSLRNSTRATPSRR- 439

  Fly   441 SATPGISGSSAVKRRRTVIDESEDRTLSEYSVNAAAKGDLEIIEADVEGRFIKLHNKGTEEINLT 505
              ||    |:||||:|.|:|||||.::::|.|:|:|||::||.|.|.||:|::|.|||:||:.:.
  Fly   440 --TP----SAAVKRKRAVVDESEDHSVADYYVSASAKGNVEIKEIDPEGKFVRLFNKGSEEVAIG 498

  Fly   506 GWQLTRIAGDE--ELAFKFSRGSKVLGGASVTIWSVDAGTAHDPPNNLVMK-KKWPVANSMRSVL 567
            ||||.|:..::  ...:||.|..::.....:|:||.|...:|:||::|||| :||..|::.|::|
  Fly   499 GWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTKASHEPPSSLVMKSQKWVSADNTRTIL 563

  Fly   568 --------ANADKEVRVLS 578
                    ||.|:..|::|
  Fly   564 LNSEGEAVANLDRIKRIVS 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	222/355 (63%)
		ATP-synt_B	<67..>142	CDD:304375	46/74 (62%)
		MreC	<178..>224	CDD:302802	29/45 (64%)
		LTD	473..574	CDD:279300	44/111 (40%)
Lam	NP_001245892.1	Filament	54..409	CDD:278467	222/354 (63%)
		Ax_dynein_light	<283..377	CDD:287215	47/93 (51%)
		LTD	466..572	CDD:279300	41/105 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473075
Domainoid	1	1.000	268	1.000	Domainoid score	I1815
eggNOG	1	0.900	-	-		E1_KOG0977
Homologene	1	1.000	-	-		H7818
Inparanoid	1	1.050	393	1.000	Inparanoid score	I1927
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48052
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		mtm6402
orthoMCL	1	0.900	-	-		OOG6_103212
Panther	1	1.100	-	-	P	PTHR45721
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2618
SonicParanoid	1	1.000	-	-		X632
	14	13.840