DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and Krt73

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001008808.2	Gene:	Krt73 / 300248	RGDID:	1359597	Length:	539	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	113/475 - (23%)
Similarity:	208/475 - (43%)	Gaps:	103/475 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SARRVTLNTRVSRASTSTPVGG-----------ASTSSRVGATSPTSPT---------------- 39
            |.|.::.|.    ||.|...||           |.:....||..|::|:
  Rat    52 SPRSISFNV----ASGSGRTGGYGFGRNRASGFAGSMFGGGALGPSNPSLCLPGGIHQVTVNKSL 112

  Fly    40 ------------RTSRQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQD-TVNRETSN 91
                        :..|.||:|:::.||::.|.:||::|.||.:|..|..:..|.|. .::....|
  Rat   113 LAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLQTKWELLQQLDLSNCRRN 177

  Fly    92 LKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRY 156
            |:.|||..:::.:|.||..:.::.:|:.:::.:.:..:|.|.|.:::..:.|.|||
  Rat   178 LEPVYEAHISSLQKQLDSLSGDRVRLDSELRGMRDAVEDCKKRYEEEINKRTTAEN--------- 233

  Fly   157 NEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAF 221
                                  |..:           |:|.::|..:::|:|:.:..:|..|:.|
  Rat   234 ----------------------EFVV-----------LKKDVDAAYMSKVELQAKVDALDGEIKF 265

  Fly   222 KDQVHTQELTETRSRRQIEISEIDGRLS--RQYEAKLQQSLQELRDQYEGQMRINREEIELLYDN 284
            ...::..|:|:.:|    .||:....||  ......|...:.|:|.|||.....::.|.|::|..
  Rat   266 LKCLYEGEITQMQS----HISDTSVVLSMDNNRNLDLDSIIAEVRAQYEDIALKSKAEAEMVYQT 326

  Fly   285 EIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRH 349
            :.|.|:.||.|..........|:..:...|..|.:::::::...:.|...|.:.|...|...:..
  Rat   327 KFQELQLAAGRHGDDLKHTRNEISELTRLIQRLRSEIESVKKQCSNLETAIADAEQRGDCALKDA 391

  Fly   350 NQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDS 414
            ...:..||..|.:.::|:|..|:|:|.||.:|::||:|||.|.|||.|||.|:           |
  Rat   392 QAKLDDLERALHQAKEELARMLREHQELMSMKLALDIEIATYRKLLEGEECRM-----------S 445

  Fly   415 GISSNGSHLTASASSRSGRV 434
            |..:|...::..:||.:|.|
  Rat   446 GEHTNAVSISVISSSTTGAV 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	91/358 (25%)
		ATP-synt_B	<67..>142	CDD:304375	18/75 (24%)
		MreC	<178..>224	CDD:302802	9/45 (20%)
		LTD	473..574	CDD:279300
Krt73	NP_001008808.2	Head	1..130		14/81 (17%)
		Keratin_2_head	15..127	CDD:406589	13/78 (17%)
		Filament	130..443	CDD:365827	91/358 (25%)
		Coil 1A	131..166		12/34 (35%)
		Linker 1	167..185		6/17 (35%)
		Coil 1B	186..277		22/132 (17%)
		Linker 12	278..301		6/26 (23%)
		Coil 2	302..440		40/137 (29%)
		Tail	441..539		9/36 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910