DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and Krt75

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001008828.2	Gene:	Krt75 / 300247	RGDID:	1359576	Length:	555	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	121/492 - (24%)
Similarity:	206/492 - (41%)	Gaps:	106/492 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SARRVTLNTRVSRASTSTPVGGASTSSRVGATSPTSPT-RTSRQQEKEELQHLNDRLACYIDRMR 65
            |.:.||:|     .|..||:           .....|| :..|::|:|:::.||::.|.:||::|
  Rat   111 SIQEVTVN-----QSLLTPL-----------NLQIDPTIQRVRKEEREQIKTLNNKFASFIDKVR 159

  Fly    66 NLENENSRLTQELNLAQDTVNRET-SNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEEND 129
            .||.:|..|..:.||.|:..:|.. .||:..::..:...|:.||....|:.:|:.:::.:.|..:
  Rat   160 FLEQQNKVLETKWNLLQEQGSRTVRQNLEPFFDAYVNDLRRQLDSVTAERGRLDAELRHMQEVVE 224

  Fly   130 DLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDL 194
            |.|.|                 ||:..|                    |..|.|||.:     .|
  Rat   225 DFKVR-----------------YEDEIN--------------------KRAAAENEFV-----GL 247

  Fly   195 RKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQS 259
            :|.::...:.:|:||.:..||.:::.|...|:..||::.::  |:..:.:...:.......|...
  Rat   248 KKDVDGAYMNKVELEAKVDSLTDQINFYRMVYEAELSQMQN--QVSDTSVVLSMDNNRSLDLDSI 310

  Fly   260 LQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNL 324
            :.|::.|||.....:|.|.|..|..:.:.|:..|.|.........:|:..|...|..|.:::..:
  Rat   311 IAEVKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRSEIDAV 375

  Fly   325 EDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIA 389
            :...:.|...|.:.|...:...:.....:..||..||:.:.:||..|:|||.||::|::||:|||
  Rat   376 KKQCSSLQTAISDTEQRGELALKDARAKLVELEDALQKAKQDMARLLREYQELMNVKLALDVEIA 440

  Fly   390 AYDKLLCGEERRLNIE-------------SPG-------RPTTDSG------------------- 415
            .|.|||.|||.||:.|             .||       ..|..||
  Rat   441 TYRKLLEGEECRLSGEGVSPVNICEYDPCGPGLSWSAVVTSTVSSGYGGGTNIGGGSLGLGGNSG 505

  Fly   416 --ISSNGSHLTASASSRSGRVTPSGRRSATPGISGSS 450
              .::.|.|...:....||..|.|.|   .|..||||
  Rat   506 YSFTTTGGHSLGTGLGGSGFTTSSSR---GPVGSGSS 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	91/356 (26%)
		ATP-synt_B	<67..>142	CDD:304375	19/75 (25%)
		MreC	<178..>224	CDD:302802	13/45 (29%)
		LTD	473..574	CDD:279300
Krt75	NP_001008828.2	Keratin_2_head	16..136	CDD:406589	9/40 (23%)
Krt75	NP_001008828.2	Filament	139..452	CDD:365827	91/356 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910