DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LamC and Lmnb2

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001292164.1	Gene:	Lmnb2 / 299625	RGDID:	1563803	Length:	616	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	212/569 - (37%)
Similarity:	326/569 - (57%)	Gaps:	41/569 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRE 88
            ||...|.|:.:|.||||.||.||||||:.||||||.||||:|.||.||.:|...::..::...||
  Rat    20 ASLPPRAGSATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDKLLLRISEKEEVTTRE 84

  Fly    89 TSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYE 153
            .|.:|.:||.|||.||::|||||:|:|:|:|:|.::..|.::.|....|:..|.|||....:..|
  Rat    85 VSGIKTLYESELADARRVLDETARERARLQIEIGKVQAELEEAKKSAKKREGELTVARGRVKDLE 149

  Fly   154 NRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQL---DD----LRKQLEAETLARVDLENQ 211
            :.::....:...:|.|:...|.:..|       ||.||   :|    .:||||.|||.||||||.
  Rat   150 SLFHRSEAELAAALGDKHVLETEVAE-------LRAQLAKAEDGHAVAKKQLEKETLMRVDLENH 207

  Fly   212 NQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQSLQELRDQYEGQMRINRE 276
            .|||:|||||...|..:|:.|||.|.:..:.|:|....::|:.|:.|:|:|||.|::.|:|:.|.
  Rat   208 CQSLQEELAFSKSVFEEEVQETRRRHERHLVEVDSSRQQEYDFKIAQALEELRSQHDEQVRLYRL 272

  Fly   277 EIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENL 341
            |:|..|..::.|.|..:::..:.:..|.||::..|.:::.|:.:|..|:...:.....|||||..
  Rat   273 ELEQTYQAKLDNTKLISDQNDKAARAAREELKEARMRVESLSYQLSGLQKQASAAEDHIRELEEA 337

  Fly   342 LDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIES 406
            |..||.:....:.:.|.|:..:||.|..||.|||.|:|||::||:||.:|.|||.|||.||.:.
  Rat   338 LAGERDKFRNMLDAKEQEMAEVRDAMQQQLAEYQELLDIKLALDMEICSYRKLLEGEEERLKLS- 401

  Fly   407 PGRPTTDSGISSNGSHLTASASSRSGRVTPSGRRSATPGIS-GSSAVKRRRTVIDESEDRTLSEY 470
               |:..|.::.:.:..::|:||.||           .|:| |....||:|...:::.....|..
  Rat   402 ---PSPSSRVTISLATSSSSSSSSSG-----------VGMSLGRGRSKRQRLETEDTPGSPSSAS 452

  Fly   471 SVN--------AAAKGDLEIIEADVEGRFIKLHNKGTEEINLTGWQLTR-IAGDEELAFKFSRGS 526
            ||:        |.|.|.:.|.|.|:||||::|.|...::.:|..|::.: :...|::|:||:...
  Rat   453 SVSSGSRLAQQAGATGVVNIDEVDLEGRFVRLKNSSDKDQSLGNWRIKKQVLEGEDIAYKFTPKY 517

  Fly   527 KVLGGASVTIWSVDAGTAHDPPNNLVMKKK--WPVANSMRSVLANADKE 573
            .:..|.:||:|:..||..|.||:.||.|.:  |....:.|:||.|||.|
  Rat   518 VLRAGQTVTVWAAGAGATHSPPSTLVWKNQSSWGSGENFRTVLVNADGE 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	145/362 (40%)
		ATP-synt_B	<67..>142	CDD:304375	29/74 (39%)
		MreC	<178..>224	CDD:302802	27/52 (52%)
		LTD	473..574	CDD:279300	38/112 (34%)
Lmnb2	NP_001292164.1	Filament	41..397	CDD:278467	145/362 (40%)
Lmnb2	NP_001292164.1	LTD	463..570	CDD:279300	38/104 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1753
eggNOG	1	0.900	-	-		E1_KOG0977
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7818
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1917
OMA	1	1.010	-	-		QHG48052
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		mtm9150
orthoMCL	1	0.900	-	-		OOG6_103212
Panther	1	1.100	-	-	O	PTHR45721
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X632
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840