Protein Alignment LamC and Krt18

DIOPT Version :9

• Sequence 1: NP_001260974.1
• Gene: LamC / 36615
• FlyBaseID: FBgn0010397
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_446428.1
• Gene: Krt18 / 294853
• RGDID: 619935
• Length: 423
• Species: Rattus norvegicus
• Alignment Length: 442
• Identity: 119/442 - (26%)
• Similarity: 193/442 - (43%)
• Gaps: 95/442 - (21%)

  Fly    13 SRASTSTPVGGASTSSR----VGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSR 73
            ||.|.|..|.|.|..|.    :|..          |.|||.:|.||||||.|:|:::|||.||.|
  Rat    45 SRISVSRSVWGGSVGSAGLAGMGGV----------QTEKETMQDLNDRLASYLDKVKNLETENRR 99

  Fly    74 LTQELNLAQDTVNRETSNLK--AVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLD 136
            |  |..:.:....|....::  ..|.|.:...|..:...:.:.|::.:.|
  Rat   100 L--ESKIREYLEKRGPQGVRDWGHYFKTIEDLRAQIFANSVDNARIVLQI--------------- 147

  Fly   137 KKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDLRKQLEAE 201
                      :||||..:.:..   ||...||.|:..|.              .:..|||.::..
  Rat   148 ----------DNARLAADDFRV---KYETELAMRQSVES--------------DIHGLRKVVDDT 185

  Fly   202 TLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEIS----EIDGRLSRQYEAKLQQSLQE 262
            .:.|:.||.:.::|:|||.|..:.|.:|:....:  ||..|    |:|...|:.    |.:.:.:
  Rat   186 NITRLQLETEIEALKEELLFMKKNHEEEVQGLEA--QIASSGLTVEVDAPKSQD----LSKIMAD 244

  Fly   263 LRDQYEGQMRINREEIELLYDNEIQ------NLKAAANRAAQGSALATEEVRLMRTKIDGLNAKL 321
            :|.|||...:.||||::..:..:|:      ..|:|..|.|:.:.|.      :|..:..|...|
  Rat   245 IRAQYEQLAQKNREELDKYWSQQIEESTTVVTTKSAEIRDAETTLLE------LRRTLQTLEIDL 303

  Fly   322 QNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDL 386
            .::::.|..|...:.|:|.....:.::.|..:..||:||.:.|.|...|.|||:.|::|||.|:.
  Rat   304 DSMKNQNINLENNLGEVEARYRVQMEQLNGVLLHLESELAQTRAEGQRQTQEYEALLNIKVKLEA 368

  Fly   387 EIAAYDKLL-CGEERRLNIESPGRPTTDSGISSNGSHLTASASSR---SGRV 434
            |||.|.:|| .|::..||         |:..|||........::|   .|:|
  Rat   369 EIATYRRLLEDGDDFSLN---------DALDSSNSMQTVQRTTTRKVVDGKV 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	100/368 (27%)
		ATP-synt_B	<67..>142	CDD:304375	13/76 (17%)
		MreC	<178..>224	CDD:302802	11/45 (24%)
		LTD	473..574	CDD:279300
Krt18	NP_446428.1	Head. /evidence=ECO:0000255	2..71		9/35 (26%)
		Necessary for interaction with PNN. /evidence=ECO:0000250|UniProtKB:P05783	62..366		94/369 (25%)
		Interaction with TRADD. /evidence=ECO:0000250|UniProtKB:P05783	69..121		22/63 (35%)
		Filament	72..378	CDD:278467	98/361 (27%)
		Coil 1A. /evidence=ECO:0000255	72..107		20/36 (56%)
		Linker 1. /evidence=ECO:0000255	108..125		2/16 (13%)
		Coil 1B. /evidence=ECO:0000255	126..217		26/132 (20%)
		Linker 12. /evidence=ECO:0000255	218..241		7/28 (25%)
		Interaction with DNAJB6. /evidence=ECO:0000250|UniProtKB:P05783	236..384		45/157 (29%)
		Coil 2. /evidence=ECO:0000255	242..380		43/143 (30%)
		Tail. /evidence=ECO:0000255	381..423		9/40 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000