DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and Krt20

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_775151.2	Gene:	Krt20 / 286912	RGDID:	628646	Length:	431	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	117/543 - (21%)
Similarity:	190/543 - (34%)	Gaps:	223/543 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GGASTSSRVGATSPTSPTRTSR------QQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNL 80
            ||..|...|..|:.:.....|.      ..||..:|:||||||.|::::|:||..||
  Rat    47 GGHGTRISVSKTTMSYGNHLSNGGDLFGGNEKLAMQNLNDRLASYLEKVRSLEQSNS-------- 103

  Fly    81 AQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVA 145
                                               |||..||:.:|.|                |
  Rat   104 -----------------------------------KLEAQIKQWYETN----------------A 117

  Fly   146 ENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLD-------DLRKQLEAE-- 201
            .:..|.|.:.|.::           |:.:||.|:..:||.|...|:|       |.|.:.|.|
  Rat   118 PSTIRDYSSYYAQI-----------KELQDQIKDAQIENARCVLQIDNAKLAAEDFRLKFETERG 171

  Fly   202 -------------------TLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQ--------- 238
                               ||.:.|||.|.:.|.::||...:.|.:|:...  |||
  Rat   172 MRITVEADLQGLSKVYDDLTLQKTDLEIQIEELNKDLALLKKEHQEEVEVL--RRQLGNNVNVEV 234

  Fly   239 -----IEISEIDGRLSRQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQ 298
                 :.:.||...:.::||...|::|||.::|:|.|.:...:::.:       |:
  Rat   235 DAAPGLNLGEIMNEMRQKYEILAQKNLQEAKEQFERQTQTLEKQVTV-------NI--------- 283

  Fly   299 GSALATEEVRLMRTKIDGLNAKLQNLE-DTNAGLNARIRELENLLDTERQRH-------NQYIAS 355
                  ||:|....::..|....|.|| :..:.|:.: ..||..|:..:.|:       .:.::|
  Rat   284 ------EELRGTEVQVTELRRSYQTLEIELQSQLSMK-ESLERTLEETKARYASQLAAIQEMLSS 341

  Fly   356 LEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNG 420
            |||:|.::|.:...|.|||..|:|||..|:.|||.|.:||
  Rat   342 LEAQLMQIRSDTERQNQEYNILLDIKTRLEQEIATYRRLL------------------------- 381

  Fly   421 SHLTASASSRSGRVTPSGRRSATPGISGSSAVKRRRTVIDESEDRTLSEYSVNAAAKGDLE---- 481
                                                    |.||...:||.:|.....|::
  Rat   382 ----------------------------------------EGEDIKTTEYQLNTLEAKDIKKTRK 406

  Fly   482 ---IIEADVEGRFIKLHNKGTEE 501
               ::|..|:|:.:....|..||
  Rat   407 IKTVVEEVVDGKVVSSEVKEIEE 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	98/405 (24%)
		ATP-synt_B	<67..>142	CDD:304375	11/74 (15%)
		MreC	<178..>224	CDD:302802	19/73 (26%)
		LTD	473..574	CDD:279300	8/36 (22%)
Krt20	NP_775151.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Filament	76..385	CDD:365827	99/468 (21%)
		Coil 1A	77..112		20/77 (26%)
		Linker 1	113..130		6/32 (19%)
		Coil 1B	131..222		24/101 (24%)
		Linker 12	223..245		3/21 (14%)
		Coil 2	246..384		44/225 (20%)
		Tail	385..431		11/45 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910