Protein Alignment LamC and KRT6C

DIOPT Version :10

• Sequence 1: NP_001260974.1
• Gene: LamC / 36615
• FlyBaseID: FBgn0010397
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_775109.2
• Gene: KRT6C / 286887
• HGNCID: 20406
• Length: 564
• Species: Homo sapiens
• Alignment Length: 448
• Identity: 118/448 - (26%)
• Similarity: 202/448 - (45%)
• Gaps: 86/448 - (19%)

  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQD----TVNRETSNLKAVYEKELAAA 103
            |.:|:|:::.||::.|.:||::|.||.:|..|..:..|.|:    ||.:   ||:.::|:.:...
Human   160 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQ---NLEPLFEQYINNL 221

  Fly   104 RKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRY-NEVNGKYNQSL 167
            |:.||....|:.:|:.:::.:.:..:|||                     |:| :|:|
Human   222 RRQLDSIVGERGRLDSELRNMQDLVEDLK---------------------NKYEDEIN------- 258

  Fly   168 ADRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTE 232
                      |..|.|||.:     .|:|.::|..:.:|:|:.:..:|.:|:.|...::..||
Human   259 ----------KRTAAENEFV-----TLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAEL-- 306

  Fly   233 TRSRRQIEISEIDGRLS--RQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANR 295
              |:.|..||:....||  ......|...:.|::.|||...:.:|.|.|..|..:.:.|:..|.|
Human   307 --SQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGR 369

  Fly   296 AAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAEL 360
            .........:|:..:...|..|.:::.:::...|.|.|.|.:.|...:...:.....:..||..|
Human   370 HGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCASLQAAIADAEQRGEMALKDAKNKLEGLEDAL 434

  Fly   361 QRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTD------------ 413
            |:.:.::|..|:|||.||::|::||:|||.|.|||.|||.|||.|..|:....
Human   435 QKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNVSVVQSTISSGYGG 499

  Fly   414 -SGISS-------------NGSHLTASASSRSGRVTPSGRRSATPGISGSSAVKRRRT 457
             ||:.|             :|..:....||.|||....|..|..   .|||.:|...|
Human   500 ASGVGSGLGLGGGSSYSYGSGLGIGGGFSSSSGRAIGGGLSSVG---GGSSTIKYTTT 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:459643	96/362 (27%)
		PRK13922	154..>221	CDD:473155	16/67 (24%)
		LTD	474..574	CDD:460003
KRT6C	NP_775109.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		Head	2..162		1/1 (100%)
		Keratin_2_head	17..159	CDD:465068
		Filament	162..475	CDD:459643	96/362 (27%)
		Coil 1A	163..198		12/34 (35%)
		Linker 1	199..217		6/20 (30%)
		Coil 1B	218..309		28/137 (20%)
		Linker 12	310..333		6/22 (27%)
		Coil 2	334..472		40/137 (29%)
		Tail	473..564		22/85 (26%)