DRSC/TRiP Functional Genomics Resources

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Protein Alignment LamC and KRT23

DIOPT Version :10

Sequence 1:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster
Sequence 2:NP_056330.3 Gene:KRT23 / 25984 HGNCID:6438 Length:422 Species:Homo sapiens


Alignment Length:406 Identity:102/406 - (25%)
Similarity:176/406 - (43%) Gaps:71/406 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 RVSRAST--STPVGGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSR 73
            |:|.:.|  |.|..|.|..|  |.:||     ......|..:|:||||||.|::::|.||..|.:
Human    42 RISLSFTTRSCPPPGGSWGS--GRSSP-----LLGGNGKATMQNLNDRLASYLEKVRALEEANMK 99

  Fly    74 LTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKK 138
            |             |:..||...:::        ..:.|:.::.|.:|..|.|:      .:|.|
Human   100 L-------------ESRILKWHQQRD--------PGSKKDYSQYEENITHLQEQ------IVDGK 137

  Fly   139 TKEATV--AENNARLYENRYNEVNGKYNQSLADRKKFEDQ---AKELALENERLRRQLDDLRKQL 198
            ...|.:  ..:|||:..:.:|             .|:|::   .|:|.:|.|.|||.||:|    
Human   138 MTNAQIILLIDNARMAVDDFN-------------LKYENEHSFKKDLEIEVEGLRRTLDNL---- 185

  Fly   199 EAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQSLQEL 263
               |:...|||.:.:.:|:||....:.|.||:.:........::.   ::.......|.:.|:::
Human   186 ---TIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNV---KVDTGPREDLIKVLEDM 244

  Fly   264 RDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATE---EVRLMRTKIDGLNAKLQNLE 325
            |.:||..::....:::..|..:    .||.::.|...|....   ::..::.....|...||...
Human   245 RQEYELIIKKKHRDLDTWYKEQ----SAAMSQEAASPATVQSRQGDIHELKRTFQALEIDLQTQY 305

  Fly   326 DTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAA 390
            .|.:.|...:.|.::....:.|...:.|:..|.||.::|.|:..|..|||.|:.||..|:.||..
Human   306 STKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEITT 370

  Fly   391 YDKLLCGEERRLNIES 406
            |.:||.||......||
Human   371 YRRLLEGESEGTREES 386

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamCNP_001260974.1 Filament 45..401 CDD:459643 89/363 (25%)
PRK13922 154..>221 CDD:473155 20/69 (29%)
LTD 474..574 CDD:460003
KRT23NP_056330.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73 11/37 (30%)
Head 1..71 11/35 (31%)
Filament 71..380 CDD:459643 89/362 (25%)
Coil 1A 72..107 16/47 (34%)
Linker 1 108..125 2/24 (8%)
Coil 1B 126..217 32/116 (28%)
Linker 12 218..240 1/24 (4%)
Coil 2 241..378 35/140 (25%)
Rod-like helical tail 379..422 2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

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