DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and Iffo2

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_030109240.1	Gene:	Iffo2 / 212632	MGIID:	2140675	Length:	513	Species:	Mus musculus

Alignment Length:	475	Identity:	86/475 - (18%)
Similarity:	164/475 - (34%)	Gaps:	117/475 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVN 86
            ||....:..|.:..|:..|.........|:.||.|..|::.::..||..|..|.::|...|...:
Mouse    26 GGGGGGAGPGPSPVTAALRDDLGSNIHLLKGLNVRFRCFLAKVHELERRNRLLEKQLEQQQSERD 90

  Fly    87 RETSNLKAVYEKELAAARKLLDETAKEKAKL---------------------------------- 117
            |.........|:.:....:||..:|....:.
Mouse    91 RRLRYKTFSREQAVQTGPELLRPSAAGSGQALGAATGVNANAVALGGLPPGGGSHPQHYGRLPGT 155

  Fly   118 ---EIDIKRL--------------WEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQ 165
               ...::|.              |...|.:..::|..|.|.....|.....:...:|...::.:
Mouse   156 IWSYTQVRRTGGGGVETVQGPGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEE 220

  Fly   166 SLADRKKFE---DQAKELALENERLRRQLDDLRKQLEAE----------TLARVDLENQNQSLRE 217
            .||.|...:   |..:|.|.|.|.::.::::..::|:||          .:..:|.:.|.::::.
Mouse   221 ELAKRMNLQTMVDTLQEAAQEAEAIQEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKV 285

  Fly   218 ELAFKDQVH-TQELTETRSRRQIE----------------------ISEIDGRLSRQYEAKLQQS 259
            ::....::. |.:|.:...:|..|                      |||.||.::|
Mouse   286 DMDICRRIDITAKLCDVAQQRNSEDVSKIFQVVPKKKDRKVASDEDISEQDGEVNR--------- 341

  Fly   260 LQELRDQYEGQMRINREEIELL--------YDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDG 316
               ..|:..|.|.|..|...:.        :|::..:|....|   :.:.|..|:.......||
Mouse   342 ---FSDEEVGSMNITDEMKRMFNQLRETFDFDDDCDSLTWEEN---EDTLLLWEDFTNCNPTID- 399

  Fly   317 LNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIK 381
                ||..::.|.|  ..|.|.|:...|..:.:.:.|..:|.||...:.:|...|.||..:..:|
Mouse   400 ----LQGEQEENLG--NLIHETESFFKTRDKEYQETIGQIELELATAKSDMNRHLHEYMEMCSMK 458

  Fly   382 VSLDLEIAAYDKLLCGEERR 401
            ..||:::....:|:.|...|
Mouse   459 RGLDVQMETCRRLIKGSADR 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	80/450 (18%)
		ATP-synt_B	<67..>142	CDD:304375	16/125 (13%)
		MreC	<178..>224	CDD:302802	9/55 (16%)
		LTD	473..574	CDD:279300
Iffo2	XP_030109240.1	Filament	189..478	CDD:365827	61/310 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000