DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LamC and lmnl3

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_694505.2	Gene:	lmnl3 / 195817	ZFINID:	ZDB-GENE-020424-4	Length:	584	Species:	Danio rerio

Alignment Length:	584	Identity:	188/584 - (32%)
Similarity:	308/584 - (52%)	Gaps:	69/584 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TSTPV----GGASTSSRVGATSP--TSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSRLT 75
            ||||:    ..|..:||....||  .||||.:|.||||:|:.||||||.||:|:|.||.:.|.:.
Zfish     5 TSTPMERSASAAVRASRRSGASPCTVSPTRLTRLQEKEDLRQLNDRLANYIERVRQLEADKSSMQ 69

  Fly    76 QELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTK 140
            ..|...:::..||..|::.:||.|||.|||.||.||.|:|:|:|:..:|.|::..|..|.:||..
Zfish    70 ILLEEKEESSLREVGNVRRLYESELADARKSLDATANERARLQIEFSQLQEDHRKLAARNNKKEC 134

  Fly   141 EATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDLRKQLEAETLAR 205
            |.|.|.:..|..|...|.....:...|:..::.|.:..||..:...|...|..|:.||.:|.|.|
Zfish   135 ELTAAVDRWRNLEVALNAKEADFANLLSTNRRLETEISELKTQVPALEAALQKLKTQLNSEMLRR 199

  Fly   206 VDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQSLQELRDQYEGQ 270
            ||.|||.|:|:|:|.|:..:..||:.|.|||.:..:.|:|....:::|.||.:::::|||::|.|
Zfish   200 VDAENQIQTLQEQLDFQKHLGEQEVREMRSRHESRLLELDCGRQKEFEGKLAEAMKQLRDEHETQ 264

  Fly   271 MRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARI 335
            :|..::|:|..::.:::|.|..|.:.:..:....||:...:.:::....::.||:.....|.||:
Zfish   265 IRQYKDELEKTFNAKLENAKQTAVKNSDFAFSTKEELAGTKLRLESQTQQINNLQKQVVCLEARV 329

  Fly   336 RELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEER 400
            .||:..|:.|||...|.::..:.|:..:|.:|..||:||:.|:|:|:.||:||.||.|:|.|||:
Zfish   330 LELQQTLEHERQVSQQKLSQQQQEMAALRLQMQEQLEEYENLLDVKLMLDMEINAYRKMLEGEEK 394

  Fly   401 RLNIESPGRPTTDSGISSNGSHLTASASSRSGRVTPSGRRSATPGISGSSAVKRRRTVIDESEDR 465
            |||                     .|.|.....::|..::|.          |:|:      .|.
Zfish   395 RLN---------------------QSLSPIQQTLSPIIQQSR----------KKRK------HDA 422

  Fly   466 TLSEYSVN------AAAKGDLEIIEADVEGRFIKLHNKGTEEINLTGWQLTRIAGD-EELAFKFS 523
            |.|.:|.|      ::.:|.:.|.|.|::||:|||.|....:..::||||.:...: .::.|.|.
Zfish   423 TCSGFSPNYRLSQHSSCRGPVSIEEVDLDGRYIKLKNASDRDQVVSGWQLRKSEAEAPDIVFCFP 487

  Fly   524 RGSKVLGGASVTIWSVDA----GTAHDPPNNLVMK--KKWPVANSMRSVLANADKEVRVLSIYN 581
            ....:..|..:|:|:..|    |:|.|    |::.  :.|.         :.||..|.:|:|.|
Zfish   488 SPCVMNAGHMLTVWAAAAVDQCGSASD----LLLSTHQSWG---------SFADVRVSLLNIQN 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	129/355 (36%)
		ATP-synt_B	<67..>142	CDD:304375	29/74 (39%)
		MreC	<178..>224	CDD:302802	20/45 (44%)
		LTD	473..574	CDD:279300	28/113 (25%)
lmnl3	NP_694505.2	Filament	39..395	CDD:278467	129/355 (36%)
lmnl3	NP_694505.2	LTD	436..544	CDD:279300	31/116 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1815
eggNOG	1	0.900	-	-		E1_KOG0977
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48052
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		mtm6402
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45721
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X632
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.890