Protein Alignment LamC and lmna

DIOPT Version :10

• Sequence 1: NP_001260974.1
• Gene: LamC / 36615
• FlyBaseID: FBgn0010397
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_694503.1
• Gene: lmna / 195815
• ZFINID: ZDB-GENE-020424-3
• Length: 659
• Species: Danio rerio
• Alignment Length: 614
• Identity: 221/614 - (35%)
• Similarity: 346/614 - (56%)
• Gaps: 59/614 - (9%)

  Fly    19 TPVGGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQD 83
            ||  |...|||.|.|:..||||.||.||||:|.:||||||.|||::|:||.||:.|...:..::.
Zfish     3 TP--GQKRSSRGGVTNVLSPTRISRLQEKEDLSNLNDRLAVYIDKVRSLEVENAGLRMRITESET 65

  Fly    84 TVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENN 148
            .::||.|.:||.||.|||.|||.||..|||:|:|::::.::.|:..:||.|..|  |||.:....
Zfish    66 EISRELSGMKAAYEAELADARKTLDSVAKERARLQLELSKVREDYKELKARNGK--KEADLESAL 128

  Fly   149 ARL--YENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQ 211
            |||  .|:..|..:...:.:|.:::..|.:.::|..:..:|...|:|.:|||:.|.|.|||.||:
Zfish   129 ARLKDLESLLNSKDASLSTALGEKRTLEVEVRDLKAQLAKLEGSLNDAKKQLQDEMLRRVDAENR 193

  Fly   212 NQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQSLQELRDQYEGQMRINRE 276
            .|:|:|||.|:..::::||.|::.|.:..:.|||....:.||:||..:|.:||:|:|.|:||.:|
Zfish   194 IQTLKEELEFQKNIYSEELRESKRRYESRVVEIDSGRQQDYESKLADALTDLRNQHEEQLRIYKE 258

  Fly   277 EIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENL 341
            |||..|:::::|.:::|.|.:.....|.||::..|.:::|::::|..|:...|...|:|||||..
Zfish   259 EIEKTYNSKLENARSSAERNSHLVGAAHEELQQTRVRMEGVSSQLSQLQKQLAAREAKIRELEEA 323

  Fly   342 LDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIE- 405
            |..||....:.:...|.|:..||..|..||.|||.|:|||::||:||:||.|||.|||.||.:.
Zfish   324 LSRERDILRRRLEDKEKEMAEMRQRMQQQLDEYQELLDIKLALDMEISAYRKLLEGEEERLRLSP 388

  Fly   406 --SPGRPTTDSGISSNGSHLTASASSRSGRVTPSGRRSATPGISGSSAVKRRRTVIDESEDR--- 465
              .|.|..|.:..|.:|||.         ||.    :|:|...|..||.|||  :.|...|.
Zfish   389 SPPPARGVTVTRSSGSGSHT---------RVV----QSSTSRTSSGSAKKRR--LNDNDSDASSV 438

  Fly   466 -----TLSEYSVNAAAKGDLEIIEADVEGRFIKLHNKGTEEINLTGWQLTR-IAGDEELAFKFSR 524
                 |.:.....|:|.|.:.:.|.|:||:|::|:||..::.:|..||:.| |.....:.:||..
Zfish   439 VGGTVTRTRIFQQASASGRVTVDEVDLEGKFVRLNNKSDQDQSLGHWQVKRQIGSGTPIVYKFPP 503

  Fly   525 GSKVLGGASVTIWSVDAGTAHDPPNNLVMK--KKWPVANSMRSVLANA----------------D 571
            ...:..|.:||||:..||..|.||::||.|  ..|...:..::.|.::                |
Zfish   504 KFNLKAGQTVTIWAAGAGGTHSPPSDLVWKTQNSWGSGDLFQTTLISSSGEEMAMRKVTRTLFQD 568

  Fly   572 KEVRVLSIYNTCGTCD--------ICRHC 592
            :|...::.::|||..:        :|..|
Zfish   569 EEDDEMAAHSTCGDSEYNLRSRTVLCGSC 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:459643	145/357 (41%)
		PRK13922	154..>221	CDD:473155	22/66 (33%)
		LTD	474..574	CDD:460003	34/118 (29%)
lmna	NP_694503.1	Filament	27..383	CDD:459643	145/357 (41%)
		LTD	452..559	CDD:460003	33/106 (31%)