DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LamC and ifd-2

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_508160.1	Gene:	ifd-2 / 180430	WormBaseID:	WBGene00002058	Length:	443	Species:	Caenorhabditis elegans

Alignment Length:	455	Identity:	112/455 - (24%)
Similarity:	199/455 - (43%)	Gaps:	68/455 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VSRASTSTPVGGASTSSRVGATSPTSPT--RTSRQQEKEELQHLNDRLACYIDRMRNLENENSRL 74
            :....|:.|. |.:||..:.|.:..:..  |.:|::||.|:..||:|||.|::::|.||.:|..|
Worm    20 IESGRTNLPT-GITTSGALSAYAQNAAAIIRDNREREKVEIADLNNRLARYVEKVRFLEAQNRVL 83

  Fly    75 TQELNLAQDTVNRETSNLKAVYEKELAAARKLLDE------TAKEK-AKLEIDI---KRLWEEND 129
            ..::.:.::..:..:..:...:|.|.|:...|:.|      ||::. .|||.|:   |:..|.:.
Worm    84 ENDIGVFRNAAHTHSERIAVYFESEKASLFTLVRENKAKISTAEQNIRKLEPDVISAKKNLESSF 148

  Fly   130 DLK--PRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLD 192
            .|:  .|.||:::...::...|   ||.|             .|:.....:|   |..|:..::.
Worm   149 QLRVQTREDKRSQMKILSNLEA---ENSY-------------IKRLTTDCEE---EKSRVHSEIS 194

  Fly   193 DLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETR----SRRQIEISEIDGRLSRQ-- 251
            .||..::     ||      .:||::...|....:|||.:..    |:..|.|.|...:..|.
Worm   195 RLRSDIK-----RV------HALRDKERSKHSSSSQELLKRLNGCISQHDIAIREEISKARRDTT 248

  Fly   252 ------YEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLM 310
                  :..:|..:::|:||::|...|..|:..|..|..:|..:|..:...:.....|.||:..:
Worm   249 NKNRDYFHNELHAAMKEIRDRFEKDSRAARKTWEDWYHKKITEIKKGSESYSSIQNQAREEILRI 313

  Fly   311 RTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAE--LQRMRDEMAHQLQE 373
            |:.::....||.:.|..|..|..||.:| :..|.|..|..: ||..|.|  :.:||:|......|
Worm   314 RSIVNEFRGKLSDSETINQQLIKRIDDL-HFQDKENLRLFE-IALNEKENLVIKMREECTKLSVE 376

  Fly   374 YQGLMDIKVSLDLEIAAYDKLLCGEER-------RLNIESPGRPTTDSGISSNGSHLTASASSRS 431
            ...|::.:::|..||..|.||:...|.       .:...:|..|...||..:...|...||.:.|
Worm   377 LDKLVENQINLRNEINHYRKLMENAEHLRTTVQTHVTYNAPPPPLPQSGPRTTSYHAYGSAYNDS 441

Fly 432 431
Worm 442 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	96/388 (25%)
		ATP-synt_B	<67..>142	CDD:304375	21/86 (24%)
		MreC	<178..>224	CDD:302802	10/45 (22%)
		LTD	473..574	CDD:279300
ifd-2	NP_508160.1	Filament	55..402	CDD:278467	95/378 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I1825
eggNOG	1	0.900	-	-		E1_KOG0977
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7818
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.780