Protein Alignment LamC and Krt2

DIOPT Version :10

• Sequence 1: NP_001260974.1
• Gene: LamC / 36615
• FlyBaseID: FBgn0010397
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_034798.2
• Gene: Krt2 / 16681
• MGIID: 96699
• Length: 707
• Species: Mus musculus
• Alignment Length: 436
• Identity: 105/436 - (24%)
• Similarity: 200/436 - (45%)
• Gaps: 80/436 - (18%)

  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQD-TVNRETSNLKAVYEKELAAARKL 106
            :.||:|:::.||::.|.:||::|.||.:|..|..:..|.|. .|...|:||..:::..:...:|.
Mouse   196 KSQEREQIKTLNNKFASFIDKVRFLEQQNQVLRTKWELLQQLDVGSRTTNLDPIFQAYIGMLKKQ 260

  Fly   107 LDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRK 171
            :|..:.|:...|.::..:.:..:|.|.:.:.:..:.|.|||:   :.....:|:..|
Mouse   261 VDRLSAERTSQESELNNMQDLVEDFKKKYEDEINKRTSAEND---FVTIKKDVDSCY-------- 314

  Fly   172 KFEDQAKELALENERLRRQLDDLRKQLE-AETLARVDLENQNQSLREELAFKDQVHTQELTETRS 235
                      ::...|:.:||.|.:::. ..||...:|....|         |...|..:....:
Mouse   315 ----------MDKTELQARLDILAQEVNFLRTLYDAELSQLQQ---------DVTDTNVILSMDN 360

  Fly   236 RRQIEISEIDGRLSRQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGS 300
            .|.:::..|               :.|:::|||.....::.|.|.||.::.:.|:..|  ...|.
Mouse   361 NRNLDLDSI---------------IAEVQNQYEMIAHKSKAESEELYHSKYEELQVTA--VKHGD 408

  Fly   301 ALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYI-------ASLEA 358
            :|  :|:::   :|..||..:|.|:...:.:..:.:.:::.:....||....|       ..||.
Mouse   409 SL--KEIKM---EISELNRTIQRLQGEISHVKKQCKGVQDSIADAEQRGEHAIKDARGKLTDLEE 468

  Fly   359 ELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNGSHL 423
            .||:.|:::|..|::||.||:.|:|||:|||.|.|||.|||.|::    |..:.:..:|...|.:
Mouse   469 ALQQCREDLARLLRDYQELMNTKLSLDVEIATYRKLLEGEECRMS----GDFSDNVSVSITSSTI 529

  Fly   424 TASASSR----SGRVTPSGRRS-----------ATPGISGSSAVKR 454
            ::|.:|:    ||..:..||.|           :|.|..|.|:..|
Mouse   530 SSSVASKTGFGSGGQSSGGRGSYGGRGGGGGGGSTYGSGGRSSGSR 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:459643	89/364 (24%)
		PRK13922	154..>221	CDD:473155	10/67 (15%)
		LTD	474..574	CDD:460003
Krt2	NP_034798.2	Head. /evidence=ECO:0000255	1..198		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..59
		Keratin_2_head	<171..195	CDD:465068
		Filament	198..511	CDD:459643	89/364 (24%)
		Coil 1A. /evidence=ECO:0000255	199..234		12/34 (35%)
		Linker 1. /evidence=ECO:0000255	235..253		5/17 (29%)
		Coil 1B. /evidence=ECO:0000255	254..345		19/111 (17%)
		Linker 12. /evidence=ECO:0000255	346..369		4/31 (13%)
		Coil 2. /evidence=ECO:0000255	370..508		43/144 (30%)
		Tail. /evidence=ECO:0000255	509..707		17/71 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..707		12/45 (27%)