DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LamC and Krt1

DIOPT Version :9

Sequence 1:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster
Sequence 2:NP_032499.2 Gene:Krt1 / 16678 MGIID:96698 Length:637 Species:Mus musculus


Alignment Length:467 Identity:109/467 - (23%)
Similarity:205/467 - (43%) Gaps:99/467 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 GGASTSSRVGATSPTSP------------------------TRTSRQQEKEELQHLNDRLACYID 62
            ||.....|.|:..|..|                        .:..:.||:|:::.|||:.|.:||
Mouse   140 GGGFGGGRFGSMGPVCPPGGIQEVTINQSLLQPLNVEVDPQIQKVKSQEREQIKSLNDKFASFID 204

  Fly    63 RMRNLENENSRLTQELNLAQ--DTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLW 125
            ::|.||.:|..|..:..|.|  ||..| |.||...:|..::..|:.:|....::::::.::|.: 
Mouse   205 KVRFLEQQNQVLQTKWELLQQVDTTTR-TQNLDPFFENYISILRRKVDSLKSDQSRMDSELKNM- 267

  Fly   126 EENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLAD--RKKFEDQA-KELALENERL 187
                                                   |.|.:  |.|:||:. |....|||.:
Mouse   268 ---------------------------------------QDLVEEYRTKYEDEINKRTNAENEFV 293

  Fly   188 RRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQY 252
                 .::|.:::..:.:|:|:.:..:|::::.|...::..|:    |:.|.:|||.:..||...
Mouse   294 -----TIKKDVDSAYMTKVELQAKADALQQDIDFFSALYQMEM----SQMQTQISETNVVLSMDN 349

  Fly   253 EAKLQQS--LQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKID 315
            ...|...  :.|::.||:...:.::.|.|..|.::.:.|:..|.:..       :.||..:.:|.
Mouse   350 NRSLDLDGIISEVKAQYDSICQRSKAEAETFYQSKYEELQITAGKHG-------DSVRNTKMEIS 407

  Fly   316 GLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIA-------SLEAELQRMRDEMAHQLQE 373
            .||..:|.|.....|...:|.:::..::...||..:.:.       .:|..|.:.::::|..|::
Mouse   408 ELNRMIQRLRSEIDGCKKQISQIQQNINDAEQRGEKALKDAQNKLNEIEDALSQCKEDLARLLRD 472

  Fly   374 YQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNGSHLTASASSRSGRVTPSG 438
            :|.||:.|::||:|||.|.|||.|||.|::    |..|.:..:|.:.||.:.|.||..|..:..|
Mouse   473 FQELMNTKLALDMEIATYKKLLEGEEIRMS----GECTPNVSVSVSTSHTSMSGSSSRGGGSGGG 533

  Fly   439 RRSATPGISGSS 450
            |........|.|
Mouse   534 RYGGGGSYGGGS 545

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamCNP_001260974.1 Filament 45..401 CDD:278467 89/369 (24%)
ATP-synt_B <67..>142 CDD:304375 16/76 (21%)
MreC <178..>224 CDD:302802 9/45 (20%)
LTD 473..574 CDD:279300
Krt1NP_032499.2 Head 1..187 6/46 (13%)
Keratin_2_head <153..184 CDD:292825 2/30 (7%)
Filament 187..500 CDD:278467 89/369 (24%)
Coil 1A 188..223 13/34 (38%)
Linker 1 224..243 8/19 (42%)
Coil 1B 244..334 20/138 (14%)
Linker 12 335..358 7/22 (32%)
Coil 2 359..497 36/144 (25%)
DUF342 <390..504 CDD:302792 33/124 (27%)
Tail 498..637 15/52 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 505..533 8/27 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 563..637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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