DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and Krt19

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_032497.1	Gene:	Krt19 / 16669	MGIID:	96693	Length:	403	Species:	Mus musculus

Alignment Length:	417	Identity:	117/417 - (28%)
Similarity:	190/417 - (45%)	Gaps:	81/417 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RRVTLNTRVSRASTSTPVGGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLE 68
            |.|::::.....|:|...||....|..|..:.:....:.  .||..:|:||||||.|:|::|.||
Mouse    43 RGVSVSSTRFVTSSSGSYGGVRGGSFSGTLAVSDGLLSG--NEKITMQNLNDRLASYLDKVRALE 105

  Fly    69 NENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKP 133
            ..|..|..:              ::..|:|:.....:              |....::..:||:.
Mouse   106 QANGELEVK--------------IRDWYQKQGPGPSR--------------DYNHYFKTIEDLRD 142

  Fly   134 RLDKKT---KEATVAENNARLYENRYNEVNGKYNQSLADRKKFE-DQAKELALENE--RLRRQLD 192
            ::...|   .:..:..:||||..:.:             |.||| :.|..|::|.:  .|||.||
Mouse   143 KILGATIDNSKIVLQIDNARLAADDF-------------RTKFETEHALRLSVEADINGLRRVLD 194

  Fly   193 DLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEA--- 254
            :|       ||||.|||.|.:||:||||:..:.|.:|:|..|       |::.|::|.:.::
Mouse   195 EL-------TLARTDLEMQIESLKEELAYLKKNHEEEITALR-------SQVGGQVSVEVDSTPG 245

  Fly   255 -KLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLN 318
             .|.:.|.|:|.|||.....||::.|..|...|:.|....       |:.:|::::.:|::..|.
Mouse   246 VDLAKILSEMRSQYEIMAEKNRKDAEATYLARIEELNTQV-------AVHSEQIQISKTEVTDLR 303

  Fly   319 AKLQNLE-------DTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQG 376
            ..||.||       ...|.|...:.|.|.....:..:....|:..||:|..:|.::..|.|||:.
Mouse   304 RTLQGLEIELQSQLSMKAALEGTLAETEARYGVQLSQIQSVISGFEAQLSDVRADIERQNQEYKQ 368

  Fly   377 LMDIKVSLDLEIAAYDKLLCGEERRLN 403
            |||||..|:.|||.|..||.|:|...|
Mouse   369 LMDIKSRLEQEIATYRSLLEGQEAHYN 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	108/372 (29%)
		ATP-synt_B	<67..>142	CDD:304375	10/77 (13%)
		MreC	<178..>224	CDD:302802	22/47 (47%)
		LTD	473..574	CDD:279300
Krt19	NP_032497.1	Head	1..82		8/40 (20%)
		Filament	82..393	CDD:278467	108/372 (29%)
		Coil 1A	83..118		16/48 (33%)
		Linker 1	119..136		3/30 (10%)
		Coil 1B	137..228		37/110 (34%)
		Prefoldin	182..307	CDD:238453	45/145 (31%)
		Linker 12	229..251		5/28 (18%)
		BAR	247..>402	CDD:299863	49/156 (31%)
		Necessary for interaction with PNN. /evidence=ECO:0000250	247..393		48/152 (32%)
		Coil 2	252..390		45/144 (31%)
		Rod-like helical tail	391..403		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910