DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and Krt15

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_032495.2	Gene:	Krt15 / 16665	MGIID:	96689	Length:	456	Species:	Mus musculus

Alignment Length:	418	Identity:	124/418 - (29%)
Similarity:	191/418 - (45%)	Gaps:	84/418 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 EKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRET------------SNLKAVYEK 98
            ||..:|:||||||.|:|::|.||..|:.|..::   :|...:::            ..::.:.:|
Mouse    98 EKVTMQNLNDRLASYLDKVRALEQANTELEVKI---RDWYQKQSPASPDRDYSHYFKTMEEIRDK 159

  Fly    99 ELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKY 163
            .|||.   :|.:   :..||||..||..::..||            .||...|.:....::||
Mouse   160 ILAAT---IDNS---RVVLEIDNARLAADDFRLK------------YENELTLRQGVEADING-- 204

  Fly   164 NQSLADRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQ 228
                                   |||.||:|       ||||.|||.|.:.|.||||:..:.|.:
Mouse   205 -----------------------LRRVLDEL-------TLARTDLEMQIEQLNEELAYLKKNHEE 239

  Fly   229 ELTETRSRRQIEISEIDGRLSRQYEA----KLQQSLQELRDQYEGQMRINREEIELLYDNEIQNL 289
            |:.|..       |::.|:::.:.:|    .|.:.|.|:|:|||.....||.::|..:.::.:.|
Mouse   240 EMKEFS-------SQLAGQVNVEMDAAPGVDLTRMLAEMREQYEAIAEKNRRDVEAWFFSKTEEL 297

  Fly   290 -KAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYI 353
             |..|:.........||...|.|| :.||..:||:.....|||...:.|:|....|:.|:....|
Mouse   298 NKEVASNTEMIQTSKTEITDLRRT-LQGLEIELQSQLSMKAGLENSLAEVECRYATQLQQIQGVI 361

  Fly   354 ASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRL-----NIESPGRPTTD 413
            ..||.:|..:|.||..|.|||..|:|||..|:.|||.|..||.|::.::     ...|.|..:..
Mouse   362 TGLETQLSELRCEMEAQNQEYNMLLDIKTRLEQEIATYRNLLEGQDAKMAGIGVREVSLGGSSGG 426

  Fly   414 SGISSNGSHLTASA-SSRSGRVTPSGRR 440
            .|.||:.|:...|. .|..|:|..|.:|
Mouse   427 GGSSSSSSNFHISVEESVDGKVVSSRKR 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	112/371 (30%)
		ATP-synt_B	<67..>142	CDD:304375	18/86 (21%)
		MreC	<178..>224	CDD:302802	19/45 (42%)
		LTD	473..574	CDD:279300
Krt15	NP_032495.2	Head	1..97
		Filament	97..409	CDD:278467	112/371 (30%)
		Coil 1A	98..133		16/37 (43%)
		Linker 1	134..152		0/17 (0%)
		Coil 1B	153..244		39/140 (28%)
		Linker 12	245..264		3/25 (12%)
		Coil 2	265..406		50/141 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000