DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and Des

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_034173.1	Gene:	Des / 13346	MGIID:	94885	Length:	469	Species:	Mus musculus

Alignment Length:	421	Identity:	128/421 - (30%)
Similarity:	214/421 - (50%)	Gaps:	74/421 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TLNTRVSRAS-TSTPVGGAST--SSRVGATSPTS--------------------PTRTSRQQEKE 48
            ::.:||.:.| ||...||..:  |||:|.|...|                    .|||:   ||.
Mouse    48 SMTSRVYQVSRTSGGAGGLGSLRSSRLGTTRAPSYGAGELLDFSLADAVNQEFLATRTN---EKV 109

  Fly    49 ELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKE 113
            |||.||||.|.||:::|.||.:|:.|..|:|..:   .||.:.:..:||:|:...|:.::....:
Mouse   110 ELQELNDRFANYIEKVRFLEQQNAALAAEVNRLK---GREPTRVAELYEEEMRELRRQVEVLTNQ 171

  Fly   114 KAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAK 178
            :|:::::...|.::...||.:|.::.:....||||
Mouse   172 RARVDVERDNLIDDLQRLKAKLQEEIQLREEAENN------------------------------ 206

  Fly   179 ELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISE 243
                        |...|..::|.||||:|||.:.:||.||:||..:||.:|:.|.:::.|.:..:
Mouse   207 ------------LAAFRADVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQ 259

  Fly   244 IDGRLSRQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVR 308
            ::..:|:   ..|..:|:::|.|||.....|..|.|..|.:::.:|..|||:.......|.:|:.
Mouse   260 VEMDMSK---PDLTAALRDIRAQYETIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMM 321

  Fly   309 LMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQE 373
            ..|.:|.....::..|:.||..|..::||||:...:|...:...||.||.|::.::||||..|:|
Mouse   322 EYRHQIQSYTCEIDALKGTNDSLMRQMRELEDRFASEANGYQDNIARLEEEIRHLKDEMARHLRE 386

  Fly   374 YQGLMDIKVSLDLEIAAYDKLLCGEERRLNI 404
            ||.|:::|::||:|||.|.|||.|||.|:|:
Mouse   387 YQDLLNVKMALDVEIATYRKLLEGEESRINL 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	110/355 (31%)
		ATP-synt_B	<67..>142	CDD:304375	17/74 (23%)
		MreC	<178..>224	CDD:302802	16/45 (36%)
		LTD	473..574	CDD:279300
Des	NP_034173.1	Head	2..108		16/62 (26%)
		Filament_head	9..105	CDD:282575	14/56 (25%)
		Filament	106..414	CDD:278467	110/358 (31%)
		Coil 1A	109..140		16/30 (53%)
		Linker 1	141..150		2/11 (18%)
		Coil 1B	151..251		33/141 (23%)
		Linker 12	252..267		2/17 (12%)
		Interaction with NEB. /evidence=ECO:0000250\|UniProtKB:P17661	267..414		54/146 (37%)
		Coil 2A	268..286		6/17 (35%)
		Linker 2	287..294		3/6 (50%)
		Coil 2B	295..411		42/115 (37%)
		Tail	412..469		3/6 (50%)
		Interaction with CRYAB. /evidence=ECO:0000250\|UniProtKB:P17661	437..452
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0977
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810