DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LamC and IFFO2

DIOPT Version :9

Sequence 1:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster
Sequence 2:NP_001129737.1 Gene:IFFO2 / 126917 HGNCID:27006 Length:517 Species:Homo sapiens


Alignment Length:493 Identity:89/493 - (18%)
Similarity:175/493 - (35%) Gaps:123/493 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 GGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVN 86
            ||....:..|.:..|:..|.........|:.||.|..|::.::..||..|..|.::|...|....
Human    29 GGGGGGAGPGPSPVTAALRDDLGSNIHLLKGLNVRFRCFLAKVHELERRNRLLEKQLEQQQSERE 93

  Fly    87 RETSNLKAVYEKELAAARKLLDETA---------------------------------KEKAKLE 118
            |.........|:.:....:||...|                                 :...:|.
Human    94 RRLRYKTFSREQAVQTGPELLRPPAPGGGHGLSSGAAAGANANAVALGGLPPGGGSHPQHYGRLP 158

  Fly   119 ------IDIKRL--------------WEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKY 163
                  ..::|.              |...|.:..::|..|.|.....|.....:...:|...::
Human   159 GTIWSYTQVRRTGGGGVETVQGPGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEYKRRW 223

  Fly   164 NQSLADRKKFE---DQAKELALENERLRRQLDDLRKQLEAE----------TLARVDLENQNQSL 215
            .:.||.|...:   |..:|.|.|.:.::.::::..::|:||          .:..:|.:.|.:::
Human   224 EEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAM 288

  Fly   216 REELAFKDQVH-TQELTETRSRRQIE----------------------ISEIDGRLSR------- 250
            :.::....::. |.:|.:...:|..|                      |||.||.::|       
Human   289 KVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVG 353

  Fly   251 --QYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTK 313
              ....::::...:||:.::             :|::..:|....|   :.:.|..|:.......
Human   354 SMNITDEMKRMFNQLRETFD-------------FDDDCDSLTWEEN---EDTLLLWEDFTNCNPT 402

  Fly   314 IDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLM 378
            ||     ||..::.|.|  ..|.|.|:...|..:.:.:.|..:|.||...:.:|...|.||..:.
Human   403 ID-----LQGEQEENLG--NLIHETESFFKTRDKEYQETIGQIELELATAKSDMNRHLHEYMEMC 460

  Fly   379 DIKVSLDLEIAAYDKLLCGEERRLNIESPGR-PTTDSG 415
            .:|..||:::....:|:.|...| |..||.. .::|||
Human   461 SMKRGLDVQMETCRRLIKGSADR-NSPSPSSVASSDSG 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamCNP_001260974.1 Filament 45..401 CDD:278467 77/453 (17%)
ATP-synt_B <67..>142 CDD:304375 17/127 (13%)
MreC <178..>224 CDD:302802 8/55 (15%)
LTD 473..574 CDD:279300
IFFO2NP_001129737.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 104..129 4/24 (17%)
Filament 194..483 CDD:365827 57/311 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 330..349 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 478..517 8/21 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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