DRSC/TRiP Functional Genomics Resources

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Protein Alignment LamC and KRT40

DIOPT Version :10

Sequence 1:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster
Sequence 2:NP_872303.2 Gene:KRT40 / 125115 HGNCID:26707 Length:431 Species:Homo sapiens


Alignment Length:381 Identity:101/381 - (26%)
Similarity:164/381 - (43%) Gaps:63/381 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 EKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDET 110
            |||.:|.||||||.|::::|:||..|:.|...:   |:...::...:...|::.......|..:.
Human    89 EKETMQFLNDRLASYLEKVRSLEETNAELESRI---QEQCEQDIPMVCPDYQRYFNTIEDLQQKI 150

  Fly   111 AKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFED 175
            ...||           ||..|..:||           |.:|..:.:             :.|:| 
Human   151 LCTKA-----------ENSRLAVQLD-----------NCKLATDDF-------------KSKYE- 179

  Fly   176 QAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIE 240
              .||:| .:.|...:..|...||..||.:.|||...:||:|:|....:.|.:|:...|      
Human   180 --SELSL-RQLLEADISSLHGILEELTLCKSDLEAHVESLKEDLLCLKKNHEEEVNLLR------ 235

  Fly   241 ISEIDGRLSRQYEA----KLQQSLQELRDQYEGQMRINREEIE---LLYDNEIQNLKAAANRAAQ 298
             .::..|||.:.:.    .|.:.|.|:|.|.|..:..||.|.|   .:...|:...:.::....|
Human   236 -EQLGDRLSVELDTAPTLDLNRVLDEMRCQCETVLANNRREAEEWLAVQTEELNQQQLSSAEQLQ 299

  Fly   299 GSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRM 363
            |..:  |.:.|.|| ...|..:||..:.....|...:.|.|....::..:....|.:||.:|..:
Human   300 GCQM--EILELKRT-ASALEIELQAQQSLTESLECTVAETEAQYSSQLAQIQCLIDNLENQLAEI 361

  Fly   364 RDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSN 419
            |.::..|.||||.|:|:|..|:.||..|..||..|:.||:..    |.:.:..|||
Human   362 RCDLERQNQEYQVLLDVKARLEGEINTYWGLLDSEDSRLSCS----PCSTTCTSSN 413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamCNP_001260974.1 Filament 45..401 CDD:459643 95/361 (26%)
PRK13922 154..>221 CDD:473155 18/66 (27%)
LTD 474..574 CDD:460003
KRT40NP_872303.2 Head 1..89 101/381 (27%)
Filament 88..399 CDD:459643 95/361 (26%)
Coil 1A 90..124 16/36 (44%)
Linker 1 125..135 0/9 (0%)
Coil 1B 136..236 32/145 (22%)
Linker 12 237..252 3/14 (21%)
Coil 2 253..396 42/145 (29%)
Tail 397..431 6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

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