DRSC/TRiP Functional Genomics Resources

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Protein Alignment LamC and KRT74

DIOPT Version :10

Sequence 1:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster
Sequence 2:NP_778223.2 Gene:KRT74 / 121391 HGNCID:28929 Length:529 Species:Homo sapiens


Alignment Length:422 Identity:118/422 - (27%)
Similarity:193/422 - (45%) Gaps:66/422 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQD-TVNRETSNLKAVYEKELAAARKL 106
            |.||:|:::.|||:.|.:||::|.||.:|..|..:..|.|. .:|....||:.:.|..::..||.
Human   137 RAQEREQIKVLNDKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKKNLEPILEGYISNLRKQ 201

  Fly   107 LDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRK 171
            |:..:.::.:|:.:::.:.:..:|.|.|.:.:....|.|||                        
Human   202 LETLSGDRVRLDSELRSMRDLVEDYKKRYEVEINRRTTAEN------------------------ 242

  Fly   172 KFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSR 236
                   |..:           |:|..:|....:|:|:.:..||.:|:.|...::..|:.:.   
Human   243 -------EFVV-----------LKKDADAAYAVKVELQAKVDSLDKEIKFLKCLYDAEIAQI--- 286

  Fly   237 RQIEISEIDGRLS--RQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQG 299
             |...||....||  ...:..|...:.|:|..||.....::.|.|.||..:||.|:.||:|  .|
Human   287 -QTHASETSVILSMDNNRDLDLDSIIAEVRMHYEEIALKSKAEAEALYQTKIQELQLAASR--HG 348

  Fly   300 SAL---ATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQ 361
            ..|   .:|.|.|.|. |..:..::.|::...|.|...|.:.|...|...:.....:..||..|.
Human   349 DDLKHTRSEMVELNRL-IQRIRCEIGNVKKQRASLETAIADAEQRGDNALKDAQAKLDELEGALH 412

  Fly   362 RMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSN------- 419
            :.::|:|..|:|||.||.:|::||:|||.|.|||.|||.|::.|:|. ..:.|.|||:       
Human   413 QAKEELARMLREYQELMSLKLALDMEIATYRKLLEGEECRMSGENPS-SVSISVISSSSYSYHHP 476

  Fly   420 ---GSHLTASASSRSGRVTPSGRRSATPGISG 448
               |..|.|||.:.|...|.||:...|....|
Human   477 SSAGVDLGASAVAGSSGSTQSGQTKTTEARGG 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamCNP_001260974.1 Filament 45..401 CDD:459643 99/361 (27%)
PRK13922 154..>221 CDD:473155 9/66 (14%)
LTD 474..574 CDD:460003
KRT74NP_778223.2 Head 1..139 1/1 (100%)
Keratin_2_head 15..136 CDD:465068
Filament 139..452 CDD:459643 99/361 (27%)
Coil 1A 140..175 13/34 (38%)
Linker 1 176..194 5/17 (29%)
Coil 1B 195..286 22/132 (17%)
Linker 12 287..310 6/22 (27%)
Coil 2 311..449 48/140 (34%)
Tail 450..529 19/60 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 484..529 9/25 (36%)
Blue background indicates that the domain is not in the aligned region.

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