DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LamC and Krt5

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_081287.1	Gene:	Krt5 / 110308	MGIID:	96702	Length:	580	Species:	Mus musculus

Alignment Length:	414	Identity:	114/414 - (27%)
Similarity:	188/414 - (45%)	Gaps:	65/414 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQD----TVNRETSNLKAVYEKELAAA 103
            |.:|:|:::.||::.|.:||::|.||.:|..|..:..|.|:    |:.:   ||..::|:.:...
Mouse   159 RTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTIKQ---NLDPLFEQYINNL 220

  Fly   104 RKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRY-NEVNGKYNQSL 167
            |:.||....|:.:|:.:::.:.:..:|                     |:|:| :|:|
Mouse   221 RRQLDGVLGERGRLDSELRNMQDLVED---------------------YKNKYEDEIN------- 257

  Fly   168 ADRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTE 232
                      |....|||.:.     |:|.::|..:.:|:||.:..:|.:|:.|.......||
Mouse   258 ----------KRTTAENEFVM-----LKKDVDAAYMNKVELEARVDALMDEINFMKMFFDAEL-- 305

  Fly   233 TRSRRQIEISEIDGRLS--RQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANR 295
              |:.|..:|:....||  ......|...:.|::.|||.....:|.|.|..|..:.:.|:..|.|
Mouse   306 --SQMQTHVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRTEAESWYQTKYEELQQTAGR 368

  Fly   296 AAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAEL 360
            ..........|:..|...|..|.:::.|::...|.|...|.|.|...:...:.....:..||..|
Mouse   369 HGDDLRNTKHEISEMNRMIQRLRSEIDNVKKQCANLQNAIAEAEQRGELALKDARNKLTELEEAL 433

  Fly   361 QRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNGSHLTA 425
            |:.:.:||..|:|||.||:.|::||:|||.|.|||.|||.||:.|..| |.       |.|.:|.
Mouse   434 QKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVG-PV-------NISVVTN 490

  Fly   426 SASSRSGRVTPSGRRSATPGISGS 449
            |.||..|..:..|..|...|..||
Mouse   491 SVSSGYGGGSSIGVGSGFGGGLGS 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	96/362 (27%)
		ATP-synt_B	<67..>142	CDD:304375	16/78 (21%)
		MreC	<178..>224	CDD:302802	13/45 (29%)
		LTD	473..574	CDD:279300
Krt5	NP_081287.1	Head. /evidence=ECO:0000255	1..161		1/1 (100%)
		Keratin_2_head	16..158	CDD:292825
		Filament	161..474	CDD:278467	96/362 (27%)
		Coil 1A. /evidence=ECO:0000255	162..197		12/34 (35%)
		Linker 1. /evidence=ECO:0000255	198..216		5/20 (25%)
		Coil 1B. /evidence=ECO:0000255	217..309		27/138 (20%)
		Linker 12. /evidence=ECO:0000255	310..332		4/21 (19%)
		Coil 2. /evidence=ECO:0000255	333..471		43/137 (31%)
		DUF883	387..>447	CDD:295076	15/59 (25%)
		Tail. /evidence=ECO:0000255	472..580		18/51 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..580
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910