DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and Krt75

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_579935.1	Gene:	Krt75 / 109052	MGIID:	1923500	Length:	551	Species:	Mus musculus

Alignment Length:	427	Identity:	109/427 - (25%)
Similarity:	194/427 - (45%)	Gaps:	73/427 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRET-SNLKAVYEKELAAARKL 106
            |::|:|:::.||::.|.:||::|.||.:|..|..:.||.|:..:|.. .||:..::..:...|:.
Mouse   147 RKEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQEQGSRTVRQNLEPFFDTYVNDLRRQ 211

  Fly   107 LDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRK 171
            ||....|:.:|:.:::.:.|..:|.|.|                 ||:..|
Mouse   212 LDGITAERGRLDAELRNMQEVVEDFKVR-----------------YEDEIN-------------- 245

  Fly   172 KFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSR 236
                  |..|.|||.:     .|:|.:::..:.:|:||.:..||.:::.|...::..||::.::
Mouse   246 ------KRAAAENEFV-----GLKKDVDSAYMNKVELEAKVDSLTDQINFYRMIYEAELSQMQN- 298

  Fly   237 RQIEISEIDGRLSRQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSA 301
             |:..:.:...:.......|...:.|::.|||.....:|.|.|..|..:.:.|:..|.|......
Mouse   299 -QVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLR 362

  Fly   302 LATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDE 366
            ...:|:..|...|..|.:::..::...:.|...|.:.|...:...:.....:..||..||:.:.:
Mouse   363 NTKQEISEMNRMIQRLRSEIDAVKKQCSSLQTAISDAEQRGELALKDARAKLMELEDALQKAKQD 427

  Fly   367 MAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISS-NGSHLTASASSR 430
            ||..|:|||.||::|::||:|||.|.|||.|||.||:.|         |:|. |.|.:|::.||.
Mouse   428 MARLLREYQELMNVKLALDVEIATYRKLLEGEECRLSGE---------GVSPVNISVVTSTVSSG 483

  Fly   431 SG------------------RVTPSGRRSATPGISGS 449
            .|                  ..|.||..|...|:.||
Mouse   484 YGGGANIGGGSLGLGGNSGYSFTTSGGHSLGTGLGGS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	90/356 (25%)
		ATP-synt_B	<67..>142	CDD:304375	19/75 (25%)
		MreC	<178..>224	CDD:302802	13/45 (29%)
		LTD	473..574	CDD:279300
Krt75	NP_579935.1	Head	1..149		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Keratin_2_head	16..146	CDD:292825
		Filament	149..462	CDD:278467	90/356 (25%)
		Coil 1A	150..185		13/34 (38%)
		Linker 1	186..204		4/17 (24%)
		Coil 1B	205..297		27/133 (20%)
		Linker 12	298..320		2/23 (9%)
		Coil 2	321..459		40/137 (29%)
		Tail	460..551		19/70 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910