DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LamC and lmnb2

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_002940085.2	Gene:	lmnb2 / 100038111	XenbaseID:	XB-GENE-490443	Length:	623	Species:	Xenopus tropicalis

Alignment Length:	580	Identity:	216/580 - (37%)
Similarity:	337/580 - (58%)	Gaps:	27/580 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 STSTPVGGASTSSRV---GATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSRLTQE 77
            :|:||....::|.:.   |.::|.||||.||.||||||:|||||||.||||:|:||.||.||..:
Frog     2 ATATPSRSGTSSMQSPARGTSTPLSPTRISRLQEKEELRHLNDRLAVYIDRVRSLELENDRLMVK 66

  Fly    78 LNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEA 142
            ::..::...||.|.:|.:||.|||.|||:|||||:|:|:|:|::.:...:.|:|.....||..:.
Frog    67 ISEKEEVTTREVSGIKNLYESELADARKVLDETARERARLQIELGKFRSDLDELTKNYKKKDADL 131

  Fly   143 TVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVD 207
            :.|:...|..|..::....:...:|.:::..|.:..:|..:..:........:||||.|||.|||
Frog   132 STAQGRIRDLEALFHRSEAELGTALGEKRSLEAEVADLRAQLSKAEDAHAVAKKQLEKETLMRVD 196

  Fly   208 LENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQSLQELRDQYEGQMR 272
            .||:.|||:||:.|:..::.:|..|||.|.:..|.|:|......|::||.|:|.|||.|::.|::
Frog   197 FENRIQSLQEEMDFRKNIYEEESRETRKRHERRIVEVDRGHQYDYDSKLAQALDELRKQHDEQVK 261

  Fly   273 INREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRE 337
            :.:||:|..|..::.|:|.:::...:.:..|.||:...|.:|:.|:.:|..|:........||||
Frog   262 MYKEELEQTYQAKLDNIKRSSDHNDKAANTAREELTEARMRIETLSYQLSGLQKQANAAEDRIRE 326

  Fly   338 LENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRL 402
            ||.||.::|.::.:.:.|.|.|:..|||:|..||.|||.|:|:|::||:||.||.|||.|||.||
Frog   327 LEQLLSSDRDKYRKLLDSKEKEMAEMRDQMQQQLTEYQELLDVKLALDMEINAYRKLLEGEEERL 391

  Fly   403 NIE-SPGRPTTDSGISSNGSHLTASASSRSGRV--------TPSGRRSATP-GIS------GSSA 451
            .:. ||....|.|..:|:.|..|.::.|:..||        ..:|..:.|. |:|      |||
Frog   392 KLSPSPQSRVTVSRATSSSSSATRTSRSKRKRVEEEYEEGGAGTGLHTGTSLGLSHITASEGSS- 455

  Fly   452 VKRRRTVIDESEDRTLSEYSVNAAAKGDLEIIEADVEGRFIKLHNKGTEEINLTGWQLTR-IAGD 515
                |||.......|....|..|:|.|.:.|.|.|:||:::.|.|...::.:|..|:|.| |..:
Frog   456 ----RTVTSGQGSSTRFHLSQQASATGSISIEEIDLEGKYVHLKNNSDKDQSLGNWRLKRKIGEE 516

  Fly   516 EELAFKFSRGSKVLGGASVTIWSVDAGTAHDPPNNLVMKKK--WPVANSMRSVLANADKE 573
            ||:.:||:....:..|.||.|:|.|||.||.||:.||.|.:  |...:::|:.|.|.::|
Frog   517 EEIVYKFTPKYVLKAGQSVKIYSADAGVAHSPPSILVWKNQSTWGTGSNIRTYLVNTEEE 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	141/355 (40%)
		ATP-synt_B	<67..>142	CDD:304375	31/74 (42%)
		MreC	<178..>224	CDD:302802	19/45 (42%)
		LTD	473..574	CDD:279300	39/104 (38%)
lmnb2	XP_002940085.2	Filament	34..390	CDD:365827	141/355 (40%)
lmnb2	XP_002940085.2	LTD	474..581	CDD:395746	39/103 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	276	1.000	Domainoid score	I1707
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7818
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1944
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		mtm9565
Panther	1	1.100	-	-	O	PTHR45721
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X632
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160