DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and nefmb

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001116752.1	Gene:	nefmb / 100033387	ZFINID:	ZDB-GENE-070103-4	Length:	717	Species:	Danio rerio

Alignment Length:	564	Identity:	147/564 - (26%)
Similarity:	246/564 - (43%)	Gaps:	143/564 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SARRVTLNTRVSRASTST--------PVGGAST---SSRVGATSP---TSPTRTS---------- 42
            |:||..|.||..|..|||        |:....|   ||...|.||   .||....
Zfish     6 SSRRRALETRSIRPPTSTVRSWAKSSPLSFKRTTNVSSSRAAYSPAVLASPDGFELSAALNGDPV 70

  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELN-LAQDTVNRETSNLKAVYEKELAAARKL 106
            |..|||:||.||||.|.|||::|.||.:|.:|..|:. |.|..:::....  ..|::||...|..
Zfish    71 RNNEKEQLQGLNDRFASYIDKVRFLEEQNKQLEAEIQALKQQKLSQSLQT--DAYDRELQDLRCA 133

  Fly   107 LDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRK 171
            |::..||||::.:|...:   ::||:                 |:                  |:
Zfish   134 LEQLHKEKAQILLDTDHM---DEDLQ-----------------RI------------------RE 160

  Fly   172 KFEDQAKELALENERLRRQLD----DLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTE 232
            ::||::        |||..:|    .::|..:...|.::|||.:.|:|.:|:.|..|.|.:|::|
Zfish   161 RYEDES--------RLREHMDAAIRGMKKDKDDSVLMKMDLERKVQALVDEMDFLRQNHEEEISE 217

  Fly   233 TRSRRQ------IEISEIDGRLSRQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKA 291
            ..::.|      :|:.::.       :..:..:|:::|.|.:|....|.::.|.::......|..
Zfish   218 LLAQLQAAQVPVVEMRDLQ-------KTDITSALRDIRAQLDGLSSKNLQQAEEVFKCRYAMLTD 275

  Fly   292 AANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASL 356
            ||.:.........:|:...|.:|.|.:.:|:.|..|...|..::.::|:..:|:...:.:.|..|
Zfish   276 AAEQNKDAIKSIRDEIGDYRRQIQGKSVELEALRGTKDSLERQLHDIEDRHNTDVSSYQEMIHQL 340

  Fly   357 EAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNGS 421
            |.:|:..:.|||..|:|||.|:::|::||.|||||.|||.|||.|.                 .:
Zfish   341 ENDLKGTKWEMARHLREYQDLLNVKMALDAEIAAYRKLLEGEETRF-----------------CA 388

  Fly   422 HLTASASSRSGRVTPSGRRSATPGISGSSAVKRR--RTVIDESE-----DRTLSEYSVNAAAKGD 479
            .:||.|.|:     |.           :|.||.:  ..:|:|::     |..|:|.:...|.:.:
Zfish   389 AVTAFAYSQ-----PK-----------TSKVKHKIVEEIIEETKGESDIDDDLAEVAKEVAEEAE 437

  Fly   480 LEIIEADVE------GRFIKLHNKGTEEINLTGWQLTRIAGDEE 517
            .|..|.:.|      .:......:|.||....|       ||||
Zfish   438 EEEKEEEEETVAASQAKVSSAAPEGEEEEEEEG-------GDEE 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	101/366 (28%)
		ATP-synt_B	<67..>142	CDD:304375	19/75 (25%)
		MreC	<178..>224	CDD:302802	13/49 (27%)
		LTD	473..574	CDD:279300	12/51 (24%)
nefmb	NP_001116752.1	Filament_head	5..68	CDD:282575	19/61 (31%)
nefmb	NP_001116752.1	Filament	73..385	CDD:278467	101/366 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910