Protein Alignment ttv and Extl3

DIOPT Version :10

• Sequence 1: NP_001356963.1
• Gene: ttv / 36614
• FlyBaseID: FBgn0265974
• Length: 772
• Species: Drosophila melanogaster
• Sequence 2: NP_064482.1
• Gene: Extl3 / 56819
• RGDID: 62065
• Length: 919
• Species: Rattus norvegicus
• Alignment Length: 842
• Identity: 228/842 - (27%)
• Similarity: 369/842 - (43%)
• Gaps: 197/842 - (23%)

  Fly    40 ESAKDGGVQPHEQLPSFLGAHDMQELQLLQSNQSKSLDSSKHLVTRKPD-----------CRMET 93
            |:||    |...||.:.:...:....:|:..||.| |.....|:..|.|           ||:..
  Rat   122 ENAK----QDLLQLKNVISQTEHSYKELMAQNQPK-LSLPIRLLPEKDDAGLPPPKVTRGCRLHN 181

  Fly    94 CFDFTRC--YDRFLVYIYPPEPLNSLGA--APPTSANYQKILTAIQESRYYTSDPTAACLFVLGI 154
            |||::||  ...|.|::|..:.. :.|:  .|.....:|   ..::.:.|.|.:...|||:|:.:
  Rat   182 CFDYSRCPLTSGFPVFVYDSDQF-AFGSYLDPLVKQAFQ---ATVRANVYVTENAAIACLYVVLV 242

  Fly   155 DTLDRDSLSEDYVRNVPSRLARLPYW-NNGRNHIIFNL--YSGTWPDYAENSL-GFDAGEAILAK 215
            ..:...::.:.  .::..:|..||:| .:|.||:|.||  .|.|     :|.| ....|.|::|:
  Rat   243 GEIQEPAVLQP--ADLEKQLHSLPHWRTDGHNHVIINLSRKSDT-----QNLLYNVSTGRAMVAQ 300

  Fly   216 ASMGVLQLRHGFDVSI-PLFHKQFPLRAGATGTVQSNNF-------PANKKYLLAFKGKRYVHGI 272
            ::....|.|.|||:.: ||.|           .:...||       |..:|||..|:|::.
  Rat   301 STFYAAQYRAGFDLVVSPLVH-----------AMSEPNFMEIPPQVPVKRKYLFTFQGEKI---- 350

  Fly   273 GSETRNSLFHLHNGR------------DMVLVTTCRHGKSWRELQDNRCDEDNREY--------- 316
             ...|:||....:..            |.::.|.       :.:||::.|:...|:
  Rat   351 -ESLRSSLQEARSFEEEMEGDPPADYDDRIIATL-------KAVQDSKLDQVLVEFTCKNQPKPS 407

  Fly   317 ---------DRYDYETLLQNSTFCLV--PRGRRL-----GSFRFLEALQAGCIPVLLSNAWVLPF 365
                     :|.|...||:.|||.|:  |....|     .:.|..|||:.|.:||:|.....||:
  Rat   408 LPTEWALCGEREDRLELLKLSTFALIITPGDPSLLISSGCATRLFEALEVGAVPVVLGEQVQLPY 472

  Fly   366 ESKIDWKQAAIWADERLLLQVPDIVRSIPAERIFALRQQTQVLWERYFGSIEKIVFTTFEIIRER 430
            ...:.|.:||:...:..:.:|..::||:....:.|:|:|.:.|||.||.:.:.|..|...:||.|
  Rat   473 HDMLQWNEAALVVPKPRVTEVHFLLRSLSDSDLLAMRRQGRFLWETYFSTADSIFNTVLAMIRTR 537

  Fly   431 --LPDYPVRSSLV---------------------------------------------------- 441
              :|..|:|..:.
  Rat   538 IQIPAAPIREEVAAEIPHRSGKAAGTDPNMADNGDLDLGPVETEPPYASPKYLRNFTLTVTDCYR 602

  Fly   442 -WNSSPGALLTLPTFADSSRYMP----FLLNSMGAEPRHNYTAVIYVQIGAALGPNA-------- 493
             |||:||.....| .......:|    ||.:..|..|..........:..||||.|.
  Rat   603 SWNSAPGPFHLFP-HTPFDPVLPSEAKFLGSGTGFRPIGGGAGGSGKEFQAALGGNVQREQFTVV 666

  Fly   494 --------ALYKLVRTITKSQFVERILVLWAADRPLPLKKRWPPTSHIPLHVISLGGSTRSQGAG 550
                    .|...:..:....::.:::|:|.:.: ||.:....|...:|:.|:
  Rat   667 MLTYEREEVLMNSLERLNGLPYLNKVVVVWNSPK-LPSEDLLWPDIGVPIMVV------------ 718

  Fly   551 PTSQTTEGRPSISQRFLPYDEIQTDAVLSLDEDAILNTDELDFAYTVWRDFPERIVGYPARAHFW 615
                .|| :.|::.||||::||:|:|:||:|:||.|..||:.|.:.|||:..:||||:|.|.|.|
  Rat   719 ----RTE-KNSLNNRFLPWNEIETEAILSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRYHAW 778

  Fly   616 DDSKNAWGYTSKWTNYYSIVLTGAAFYHRYYNYLYTNWLSLLLLKTVQQSSNCEDILMNLLVSHV 680
            |....:|.|.|.::...|:|||||||:|:||.|||:..:...:...|.:..|||||.||.||||:
  Rat   779 DIPHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHI 843

  Fly   681 TRKPPIKVTQRKGYKDRETGRSPWNDPDHFIQRQSCLNTFAAVFGYMPLIRSNLRMDPMLYR 742
            |||||||||.|..::.....::..:|..||.:|..|:|.|..|:|||||:.:..|:|.:|::
  Rat   844 TRKPPIKVTSRWTFRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFK 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ttv	NP_001356963.1	Exostosin	102..393	CDD:397245	79/341 (23%)
		Glyco_transf_64	477..737	CDD:430488	98/275 (36%)
Extl3	NP_064482.1	TPR_MLP1_2	<71..150	CDD:462316	7/31 (23%)
		Exostosin	190..500	CDD:397245	79/343 (23%)
		Glyco_transf_64	663..900	CDD:430488	93/254 (37%)