Protein Alignment ttv and Extl1

DIOPT Version :10

• Sequence 1: NP_001356963.1
• Gene: ttv / 36614
• FlyBaseID: FBgn0265974
• Length: 772
• Species: Drosophila melanogaster
• Sequence 2: NP_062524.2
• Gene: Extl1 / 56219
• MGIID: 1888742
• Length: 669
• Species: Mus musculus
• Alignment Length: 761
• Identity: 280/761 - (36%)
• Similarity: 410/761 - (53%)
• Gaps: 105/761 - (13%)

  Fly     4 KKRYILVFVSCAFLAYAYFGGYRLKVS----PLRPRRAQHESAKDGGVQPHEQLPSFLGAHDMQE 64
            :::...:.:|..:|.....|.:.|:::    || |.|:|             ..|.:|.|..:|.
Mouse     4 RRKSFWLALSAFWLLLVLLGVFPLRLAVLPGPL-PGRSQ-------------GWPRWLDAAFLQS 54

  Fly    65 LQLLQSNQSKSLDSSKHLVTRKPDCRMETCFDFTRCYDRFL-VYIYPPEPLNSLGAAPPTSANYQ 128
            ....::|........:  |:|...|....|||.::|..:.| ::::.|        |.|||...:
Mouse    55 FSQSETNPEDVAQLPR--VSRGSSCTWGACFDTSKCRGKVLKIFVHSP--------AGPTSEAQR 109

  Fly   129 KILTAIQESRYYTSDPTAACLFVLGIDTLDRDSLSEDYVRNVPSRLARLPYWNNGRNHIIFNLYS 193
            :||.:::.|||....|..||| :|.:.:.||        |.....|.  |.||.||||::.:||.
Mouse   110 RILDSLEGSRYSALSPADACL-LLFLPSQDR--------RGACGPLP--PNWNGGRNHLVLSLYP 163

  Fly   194 GTWPDYAENSLGFDAGEAILAKASMGVLQLRHGFDVSIPLFHKQFPLRAGATGTVQSNNFPANKK 258
            ....         ..|:|::|:||......|.|||:::|...:..|||.||.|.:|.:: |....
Mouse   164 APCT---------RLGQAMVAEASPSSDIFRPGFDLALPYLPEAHPLRGGAPGKLQQHS-PQPGA 218

  Fly   259 YLLAFKGKRYVHGIGSETRNSLFHLHNGRDMVLVTTCRHGKSWRELQDNRCDEDNREYDRYDYET 323
            .|||...::                  ||..:   |..|..:.  |.|..|::|......|..||
Mouse   219 TLLAVAEEK------------------GRWRI---TSTHASAC--LWDRHCEQDPGPQQTYPGET 260

  Fly   324 LLQNSTFCLVPRGRRLGSFRFLEALQAGCIPVLLSNAWVLPFESKIDWKQAAIWADERLLLQVPD 388
             |.|:||||:| |.|..:..||:||||||||||||..|.|||...|||.:|||.|||||.|||..
Mouse   261 -LPNATFCLIP-GHRSATSCFLQALQAGCIPVLLSPRWELPFSEVIDWTKAAIIADERLPLQVLA 323

  Fly   389 IVRSIPAERIFALRQQTQVLWERYFGSIEKIVFTTFEIIRERLPDYPVRSSLVWNSSPGALLTLP 453
            .:|.:...|:.|||||||.||..||.|:||::.||.|||::|:.......||:|||.|||||.||
Mouse   324 ALREMLPSRVLALRQQTQFLWTAYFSSVEKVIHTTLEIIQDRIWGASGHPSLMWNSPPGALLALP 388

  Fly   454 TFADSSRYMPFLLNSMGAEPRHNYTAVIYVQIGAALGPNAALYKLVRTITKSQFVERILVLWAAD 518
            ||:.|.:..||....:|:.|..:::|||:|  ||:   ..:|.||::.:..|:...:||:||.::
Mouse   389 TFSTSLQDFPFYHLQLGSGPGSSFSAVIWV--GAS---GESLLKLIQEVAGSRHCAQILILWNSE 448

  Fly   519 RPLPLKKRWPPTSHIPLHVISLGGSTRSQGAGPTSQTTEGRPSISQRFLPYDEIQTDAVLSLDED 583
            :..|  .|||.|: :||.||                  :|...:|.||.||..|.|:.:||||..
Mouse   449 KLPP--DRWPETA-VPLTVI------------------KGHRKVSNRFFPYSNISTNVILSLDAQ 492

  Fly   584 AILNTDELDFAYTVWRDFPERIVGYPARAHFWDDSKNAWGYTSKWTNYYSIVLTGAAFYHRYYNY 648
            :.|:|.|:|||:.||:.||||:||:.:.:||||:::..|||.:..||.:|:|||.||||||||:.
Mouse   493 STLSTSEVDFAFVVWQSFPERMVGFLSGSHFWDEAQGGWGYRTGMTNEFSMVLTTAAFYHRYYHT 557

  Fly   649 LYTNWLSLLLLKTVQQSSNCEDILMNLLVSHVTRKPPIKVTQRKGYKD---RETGRSPWNDPDHF 710
            |:|:.|...|.....::..|.|:|||.||:.||:.|||||...:.:.:   .::| .|...|:..
Mouse   558 LFTHSLPKALRTIADETPTCVDVLMNFLVATVTKLPPIKVPYGRQHPEAVPMDSG-DPRPVPEPQ 621

  Fly   711 IQRQSCLNTFAAVFGYMPLIRSNLRMDPMLYRDPVSNLRKKYRQIE 756
            ...|.|:|..||.||:|||:.|.:|:||:|::||||..|||||.:|
Mouse   622 PLDQDCINRLAAGFGHMPLVSSQVRLDPVLFKDPVSVQRKKYRSLE 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ttv	NP_001356963.1	Exostosin	102..393	CDD:397245	103/291 (35%)
		Glyco_transf_64	477..737	CDD:430488	103/262 (39%)
Extl1	NP_062524.2	Exostosin	89..328	CDD:397245	103/292 (35%)
		Glyco_transf_64	412..648	CDD:430488	103/262 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..621		3/20 (15%)