Protein Alignment ttv and Extl3

DIOPT Version :10

• Sequence 1: NP_001356963.1
• Gene: ttv / 36614
• FlyBaseID: FBgn0265974
• Length: 772
• Species: Drosophila melanogaster
• Sequence 2: NP_061258.2
• Gene: Extl3 / 54616
• MGIID: 1860765
• Length: 919
• Species: Mus musculus
• Alignment Length: 842
• Identity: 229/842 - (27%)
• Similarity: 368/842 - (43%)
• Gaps: 197/842 - (23%)

  Fly    40 ESAKDGGVQPHEQLPSFLGAHDMQELQLLQSNQSKSLDSSKHLVTRKPD-----------CRMET 93
            |:||    |...||.:.:...:....:|:..||.| |.....|:..|.|           ||:..
Mouse   122 ENAK----QDLLQLKNVISQTEHSYKELMAQNQPK-LSLPIRLLPEKDDAGLPPPKVTRGCRLHN 181

  Fly    94 CFDFTRC--YDRFLVYIYPPEPLNSLGA--APPTSANYQKILTAIQESRYYTSDPTAACLFVLGI 154
            |||::||  ...|.||:|..:.. :.|:  .|.....:|   ..::.:.|.|.:...|||:|:.:
Mouse   182 CFDYSRCPLTSGFPVYVYDSDQF-AFGSYLDPLVKQAFQ---ATVRANVYVTENAAIACLYVVLV 242

  Fly   155 DTLDRDSLSEDYVRNVPSRLARLPYW-NNGRNHIIFNL--YSGTWPDYAENSL-GFDAGEAILAK 215
            ..:...::...  .::..:|..||:| .:|.||:|.||  .|.|     :|.| ....|.|::|:
Mouse   243 GEMQEPTVLRP--ADLEKQLFSLPHWRTDGHNHVIINLSRKSDT-----QNLLYNVSTGRAMVAQ 300

  Fly   216 ASMGVLQLRHGFDVSI-PLFHKQFPLRAGATGTVQSNNF-------PANKKYLLAFKGKRYVHGI 272
            ::....|.|.|||:.: ||.|           .:...||       |..:|||..|:|::.
Mouse   301 STFYAAQYRAGFDLVVSPLVH-----------AMSEPNFMEIPPQVPVKRKYLFTFQGEKI---- 350

  Fly   273 GSETRNSLFHLHNGR------------DMVLVTTCRHGKSWRELQDNRCDEDNREY--------- 316
             ...|:||....:..            |.::.|.       :.:||::.|:...|:
Mouse   351 -ESLRSSLQEARSFEEEMEGDPPADYDDRIIATL-------KAVQDSKLDQVLVEFTCKNQPKPS 407

  Fly   317 ---------DRYDYETLLQNSTFCLV--PRGRRL-----GSFRFLEALQAGCIPVLLSNAWVLPF 365
                     :|.|...||:.|||.|:  |....|     .:.|..|||:.|.:||:|.....||:
Mouse   408 LPTEWALCGEREDRLELLKLSTFALIITPGDPHLLISSGCATRLFEALEVGAVPVVLGEQVQLPY 472

  Fly   366 ESKIDWKQAAIWADERLLLQVPDIVRSIPAERIFALRQQTQVLWERYFGSIEKIVFTTFEIIRER 430
            ...:.|.:||:...:..:.:|..::||:....:.|:|:|.:.|||.||.:.:.|..|...:||.|
Mouse   473 HDMLQWNEAALVVPKPRVTEVHFLLRSLSDSDLLAMRRQGRFLWETYFSTADSIFNTVLAMIRTR 537

  Fly   431 --LPDYPVRSSLV---------------------------------------------------- 441
              :|..|:|..:.
Mouse   538 IQIPAAPIREEVAAEIPHRSGKAAGTDPNMADNGDLDLGPVETEPPYASPKYLRNFTLTVTDCYR 602

  Fly   442 -WNSSPGALLTLPTFADSSRYMP----FLLNSMGAEPRHNYTAVIYVQIGAALGPNA-------- 493
             |||:||.....| .......:|    ||.:..|..|..........:..||||.|.
Mouse   603 GWNSAPGPFHLFP-HTPFDPVLPSEAKFLGSGTGFRPIGGGAGGSGKEFQAALGGNVQREQFTVV 666

  Fly   494 --------ALYKLVRTITKSQFVERILVLWAADRPLPLKKRWPPTSHIPLHVISLGGSTRSQGAG 550
                    .|...:..:....::.:::|:|.:.: ||.:....|...:|:.|:
Mouse   667 MLTYEREEVLMNSLERLNGLPYLNKVVVVWNSPK-LPSEDLLWPDIGVPIMVV------------ 718

  Fly   551 PTSQTTEGRPSISQRFLPYDEIQTDAVLSLDEDAILNTDELDFAYTVWRDFPERIVGYPARAHFW 615
                .|| :.|::.||||::||:|:|:||:|:||.|..||:.|.:.|||:..:||||:|.|.|.|
Mouse   719 ----RTE-KNSLNNRFLPWNEIETEAILSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRYHAW 778

  Fly   616 DDSKNAWGYTSKWTNYYSIVLTGAAFYHRYYNYLYTNWLSLLLLKTVQQSSNCEDILMNLLVSHV 680
            |....:|.|.|.::...|:|||||||:|:||.|||:..:...:...|.:..|||||.||.||||:
Mouse   779 DIPHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHI 843

  Fly   681 TRKPPIKVTQRKGYKDRETGRSPWNDPDHFIQRQSCLNTFAAVFGYMPLIRSNLRMDPMLYR 742
            |||||||||.|..::.....::..:|..||.:|..|:|.|..|:|||||:.:..|:|.:|::
Mouse   844 TRKPPIKVTSRWTFRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFK 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ttv	NP_001356963.1	Exostosin	102..393	CDD:397245	80/341 (23%)
		Glyco_transf_64	477..737	CDD:430488	98/275 (36%)
Extl3	NP_061258.2	Required for interaction with REG3A. /evidence=ECO:0000250|UniProtKB:O43909	1..140		6/21 (29%)
		TPR_MLP1_2	<76..150	CDD:462316	7/31 (23%)
		Exostosin	190..500	CDD:397245	80/343 (23%)
		Glyco_transf_64	663..900	CDD:430488	93/254 (37%)