DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttv and ext1c

DIOPT Version :9

Sequence 1:	NP_001356963.1	Gene:	ttv / 36614	FlyBaseID:	FBgn0265974	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001035420.1	Gene:	ext1c / 497281	ZFINID:	ZDB-GENE-050211-5	Length:	737	Species:	Danio rerio

Alignment Length:	782	Identity:	396/782 - (50%)
Similarity:	518/782 - (66%)	Gaps:	69/782 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQAKKRYILV-FVSCAFLAYAYFGGYRLKVSPLRPRRAQHESAKDGGVQP--------HEQLPSF 56
            |||:|:|:|: ..:|.::...|:.|.:.::..|...|.        |..|        ...||:|
Zfish     1 MQARKKYVLLGLCTCCWILLYYWAGLQERLLGLITHRR--------GEVPRPWPDWLDRALLPNF 57

  Fly    57 LGAHDMQELQLLQSN---------QSKSLDSSKHLVTRKPDCRMETCFDFTRCYDR--FLVYIYP 110
            ....|:|       |         |.|...||.:..:|   |||:|||||.||..:  |.|||||
Zfish    58 AEQLDLQ-------NGGGPGDSPRQRKQAWSSIYKDSR---CRMDTCFDFGRCQTQSGFRVYIYP 112

  Fly   111 PEPLNSLGAAPPTSANYQKILTAIQESRYYTSDPTAACLFVLGIDTLDRDSLSEDYVRNVPSRLA 175
            ||      .....|.:|:||||::.|||||||||..||||||||||||||.||:.:|.||..|:.
Zfish   113 PE------KGERVSESYRKILTSVSESRYYTSDPREACLFVLGIDTLDRDQLSQQFVPNVDERIR 171

  Fly   176 RLPYWNNGRNHIIFNLYSGTWPDYAENSLGFDAGEAILAKASMGVLQLRHGFDVSIPLFHKQFPL 240
            ..|.||:||||:||||||||||:|.|: |||:.|:|||||||:.....|.|||:|||||.|:.|.
Zfish   172 GYPLWNDGRNHVIFNLYSGTWPNYTED-LGFNVGQAILAKASLNTEHFRPGFDISIPLFSKEHPQ 235

  Fly   241 RAGATGTVQSNNFPANKKYLLAFKGKRYVHGIGSETRNSLFHLHNGRDMVLVTTCRHGKSWRELQ 305
            :.|..|.:..|:.|..:||||.||||||:.||||:|||:|.|:|||:|:|.:|||||||.|.:.:
Zfish   236 KGGKRGWLVRNSVPPRRKYLLMFKGKRYLTGIGSDTRNALHHIHNGKDIVSLTTCRHGKDWEKHK 300

  Fly   306 DNRCDEDNREYDRYDYETLLQNSTFCLVPRGRRLGSFRFLEALQAGCIPVLLSNAWVLPFESKID 370
            |.|||.||:||:|:||:.||.||||||||||||||||||||:|||.||||||||.|.|||...|.
Zfish   301 DARCDHDNQEYERFDYQELLHNSTFCLVPRGRRLGSFRFLESLQAACIPVLLSNGWELPFSDVIQ 365

  Fly   371 WKQAAIWADERLLLQVPDIVRSIPAERIFALRQQTQVLWERYFGSIEKIVFTTFEIIRERLPDYP 435
            |.||.:..|||||||||..||::..:|:.|||||||.||:.||.|::|||.||.|||::|:..:.
Zfish   366 WNQAVVEGDERLLLQVPSTVRAVGMDRVLALRQQTQTLWDAYFSSVDKIVLTTLEIIKDRVYSHI 430

  Fly   436 VRSSLVWNSSPGALLTLPTFADSSRYMPFLLNSMGAEPRHNYTAVIYVQIGAALGPNAALYKLVR 500
            .|:.|:||:.||.||.||.|:....:.||....:|..|...:||||:. ....:..:..:.||::
Zfish   431 SRNKLMWNALPGGLLVLPEFSTHLAHYPFYYLHLGISPGQEFTAVIHA-TSPLVSQSQPIMKLLQ 494

  Fly   501 TITKSQFVERILVLWAADRPLPLKKRWPPTSHIPLHVISLGGSTRSQGAGPTSQTTEGRPSISQR 565
            .::||::..:|::||.:::..|.:.:|||.. :||.|                  |:||...|.|
Zfish   495 VVSKSKYCSQIIILWNSEKSPPQRSKWPPMP-VPLTV------------------TDGRRKTSSR 540

  Fly   566 FLPYDEIQTDAVLSLDEDAILNTDELDFAYTVWRDFPERIVGYPARAHFWDDSKNAWGYTSKWTN 630
            |||:..|:|:||||||||.:|.|.|::||:.|||.||:||||||.|:||||..|.||||||||||
Zfish   541 FLPHAAIETEAVLSLDEDTVLLTSEINFAFHVWRSFPDRIVGYPPRSHFWDPVKKAWGYTSKWTN 605

  Fly   631 YYSIVLTGAAFYHRYYNYLYTNWLSLLLLKTVQQSSNCEDILMNLLVSHVTRKPPIKVTQRKGYK 695
            .|||:|||||||||||::|::::|...|...|..|.||||||||.|||.||..||:||.|||.||
Zfish   606 EYSIILTGAAFYHRYYHHLFSHYLPSSLRALVDHSCNCEDILMNFLVSSVTHLPPVKVAQRKQYK 670

  Fly   696 D----RETGRSPWNDPDHFIQRQSCLNTFAAVFGYMPLIRSNLRMDPMLYRDPVSNLRKKYRQIE 756
            :    :.|..:||.:|:||.|||.|:|||::.||||||..|..|:||:|::|.||.|||:|:.:|
Zfish   671 EMPSLQGTKMAPWANPEHFTQRQECVNTFSSWFGYMPLEHSQFRLDPVLFKDHVSVLRKRYKDLE 735

  Fly   757 LV 758
            .|
Zfish   736 RV 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttv	NP_001356963.1	Exostosin	102..393	CDD:335188	183/292 (63%)
ttv	NP_001356963.1	Glyco_transf_64	477..737	CDD:337333	130/263 (49%)
ext1c	NP_001035420.1	Exostosin	103..388	CDD:281069	183/291 (63%)
		Glyco_transf_64	472..712	CDD:286358	128/259 (49%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	536..540		1/3 (33%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	556..558		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	641..645		2/3 (67%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	679..692		5/12 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	384	1.000	Domainoid score	I777
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	793	1.000	Inparanoid score	I492
OMA	1	1.010	-	-		QHG48090
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	1	1.000	-	-		FOG0005645
OrthoInspector	1	1.000	-	-		otm26055
orthoMCL	1	0.900	-	-		OOG6_104903
Panther	1	1.100	-	-	LDO	PTHR11062
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980