DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttv and ext1a

DIOPT Version :9

Sequence 1:	NP_001356963.1	Gene:	ttv / 36614	FlyBaseID:	FBgn0265974	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001012368.2	Gene:	ext1a / 497279	ZFINID:	ZDB-GENE-050211-3	Length:	730	Species:	Danio rerio

Alignment Length:	773	Identity:	410/773 - (53%)
Similarity:	519/773 - (67%)	Gaps:	62/773 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQAKKRYILVFVS--CAFLAYAYFGGYRLKVSPLRPRRAQHESAKDGGVQPHEQLPSF---LGAH 60
            |||||||:::|.:  |..|.: |..|...:.:|.|            |..||...|.|   |.|.
Zfish     1 MQAKKRYLILFSAGVCLILLF-YLQGPASRRTPKR------------GDDPHPHWPHFSDPLRAF 52

  Fly    61 ------DMQELQLLQSNQSKSLDSSKHLVTRKPDCRMETCFDFTRC-YDRFLVYIYPPEPLNSLG 118
                  :.::..:..|.:.|..||     |....|||::||||..| .:.|.||:||.:....:
Zfish    53 IPWDQTETEDYNVRASPRHKRDDS-----TGADKCRMDSCFDFELCKRNGFKVYVYPQQKGEKI- 111

  Fly   119 AAPPTSANYQKILTAIQESRYYTSDPTAACLFVLGIDTLDRDSLSEDYVRNVPSRLARLPYWNNG 183
                 |.:||.||::|:.||:|||||..||||||.:||||||.||..||.|:.:::..|..||||
Zfish   112 -----SESYQNILSSIEGSRFYTSDPGQACLFVLNLDTLDRDQLSPQYVHNLKTKIQNLNLWNNG 171

  Fly   184 RNHIIFNLYSGTWPDYAENSLGFDAGEAILAKASMGVLQLRHGFDVSIPLFHKQFPLRAGATGTV 248
            |||:||||||||||||.|: ||||.|:|:|||||:.....|..||:|||||.|..|...|..|.:
Zfish   172 RNHLIFNLYSGTWPDYTED-LGFDIGQAMLAKASISTESFRPNFDISIPLFSKDHPRTGGERGFL 235

  Fly   249 QSNNFPANKKYLLAFKGKRYVHGIGSETRNSLFHLHNGRDMVLVTTCRHGKSWRELQDNRCDEDN 313
            :.|..|..:||:|.||||||:.||||:|||:|:|:||..|:||:|||:|||.|::.:|.|||:||
Zfish   236 KYNTIPPFRKYMLVFKGKRYLTGIGSDTRNALYHIHNAEDVVLLTTCKHGKDWQKHKDARCDKDN 300

  Fly   314 REYDRYDYETLLQNSTFCLVPRGRRLGSFRFLEALQAGCIPVLLSNAWVLPFESKIDWKQAAIWA 378
            .|||||||:.:|.||||||||||||||||||||||||.|:||:|||.|.|||...|||:.||:..
Zfish   301 AEYDRYDYKEMLHNSTFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEIIDWRTAAVIG 365

  Fly   379 DERLLLQVPDIVRSIPAERIFALRQQTQVLWERYFGSIEKIVFTTFEIIRERLPDYPVRSSLVWN 443
            |||||||:|..||||..:|:.:||||||.|||.||.|:|.||.||.|||::|:..:...|:|:||
Zfish   366 DERLLLQIPSTVRSIHQDRLLSLRQQTQFLWEAYFSSVETIVLTTLEIIQDRVLQHSAHSTLMWN 430

  Fly   444 SSPGALLTLPTFADSSRYMPFLLNSMGAEPRHNYTAVIYVQIGAALGPNAALYKLVRTITKSQFV 508
            ..||.|.|||.::......||....:|.:|...:||||:. :...:..:..::||:..:.||||.
Zfish   431 RLPGGLFTLPQYSSYLGDFPFFYALLGIKPHQKFTAVIHA-VTPLVSQSQPIFKLLVAVAKSQFC 494

  Fly   509 ERILVLWAADRPLPLKKRWPPTSHIPLHVISLGGSTRSQGAGPTSQTTEGRPSI-SQRFLPYDEI 572
            .:|:|||..|:|||.|.|||.|| :|:.||                  ||...: |.|||||:.|
Zfish   495 AQIMVLWNCDKPLPSKHRWPATS-VPVIVI------------------EGESKVMSSRFLPYENI 540

  Fly   573 QTDAVLSLDEDAILNTDELDFAYTVWRDFPERIVGYPARAHFWDDSKNAWGYTSKWTNYYSIVLT 637
            .||||||||||.:|:|.|:|||:|||:.|||||||||||:||||.:|..|||||||||.||:|||
Zfish   541 ITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDSNKERWGYTSKWTNDYSMVLT 605

  Fly   638 GAAFYHRYYNYLYTNWLSLLLLKTVQQSSNCEDILMNLLVSHVTRKPPIKVTQRKGYKDRETGR- 701
            ||||||||||||||::|...|...|.|.|||||||||.|||.||:.|||||||:|.||:...|:
Zfish   606 GAAFYHRYYNYLYTHYLPGSLKGLVDQLSNCEDILMNFLVSAVTKMPPIKVTQKKQYKETMMGQT 670

  Fly   702 ---SPWNDPDHFIQRQSCLNTFAAVFGYMPLIRSNLRMDPMLYRDPVSNLRKKYRQIE 756
               |.|.|||||.|||:|:|.||:.||.|||:.|.:|:||:|:||.||.||||||.||
Zfish   671 SRASRWADPDHFAQRQTCMNKFASWFGTMPLVHSQMRLDPVLFRDQVSILRKKYRDIE 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttv	NP_001356963.1	Exostosin	102..393	CDD:335188	174/290 (60%)
ttv	NP_001356963.1	Glyco_transf_64	477..737	CDD:337333	149/264 (56%)
ext1a	NP_001012368.2	Exostosin	94..380	CDD:281069	174/292 (60%)
		Glyco_transf_64	464..705	CDD:286358	147/260 (57%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	528..533		1/4 (25%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	549..551		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	634..638		3/3 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	672..685		7/12 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	384	1.000	Domainoid score	I777
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	793	1.000	Inparanoid score	I492
OMA	1	1.010	-	-		QHG48090
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	1	1.000	-	-		FOG0005645
OrthoInspector	1	1.000	-	-		otm26055
orthoMCL	1	0.900	-	-		OOG6_104903
Panther	1	1.100	-	-	O	PTHR11062
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2521
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010