DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttv and EXTL3

DIOPT Version :9

Sequence 1:	NP_001356963.1	Gene:	ttv / 36614	FlyBaseID:	FBgn0265974	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001431.1	Gene:	EXTL3 / 2137	HGNCID:	3518	Length:	919	Species:	Homo sapiens

Alignment Length:	852	Identity:	232/852 - (27%)
Similarity:	363/852 - (42%)	Gaps:	217/852 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ESAKDGGVQPHEQLPSFLGAHDMQELQLLQSNQSKSLDSSKHLVTRKPD-----------CRMET 93
            |:||    |...||.:.:...:....:|:..||.| |.....|:..|.|           ||:..
Human   122 ENAK----QDLLQLKNVISQTEHSYKELMAQNQPK-LSLPIRLLPEKDDAGLPPPKATRGCRLHN 181

  Fly    94 CFDFTRC--YDRFLVYIYPP---------EPLNSLGAAPPTSANYQKILTAIQESRYYTSDPTAA 147
            |||::||  ...|.||:|..         :||..........||.           |.|.:...|
Human   182 CFDYSRCPLTSGFPVYVYDSDQFVFGSYLDPLVKQAFQATARANV-----------YVTENADIA 235

  Fly   148 CLFVLGIDTLDRDSLSEDYV---RNVPSRLARLPYW-NNGRNHIIFNL--YSGTWPDYAENSL-G 205
            ||:|:.:     ..:.|..|   ..:..:|..||:| .:|.||:|.||  .|.|     :|.| .
Human   236 CLYVILV-----GEMQEPVVLRPAELEKQLYSLPHWRTDGHNHVIINLSRKSDT-----QNLLYN 290

  Fly   206 FDAGEAILAKASMGVLQLRHGFDVSI-PLFHKQFPLRAGATGTVQSNNF-------PANKKYLLA 262
            ...|.|::|:::...:|.|.|||:.: ||.|           .:...||       |..:|||..
Human   291 VSTGRAMVAQSTFYTVQYRPGFDLVVSPLVH-----------AMSEPNFMEIPPQVPVKRKYLFT 344

  Fly   263 FKGKRYVHGIGSETRNSLFHLHNGR------------DMVLVTTCRHGKSWRELQDNRCDEDNRE 315
            |:|::.     ...|:||....:..            |.::.|.       :.:||::.|:...|
Human   345 FQGEKI-----ESLRSSLQEARSFEEEMEGDPPADYDDRIIATL-------KAVQDSKLDQVLVE 397

  Fly   316 Y------------------DRYDYETLLQNSTFCLV--PRGRRL-----GSFRFLEALQAGCIPV 355
            :                  :|.|...||:.|||.|:  |...||     .:.|..|||:.|.:||
Human   398 FTCKNQPKPSLPTEWALCGEREDRLELLKLSTFALIITPGDPRLVISSGCATRLFEALEVGAVPV 462

  Fly   356 LLSNAWVLPFESKIDWKQAAIWADERLLLQVPDIVRSIPAERIFALRQQTQVLWERYFGSIEKIV 420
            :|.....||::..:.|.:||:...:..:.:|..::||:....:.|:|:|.:.|||.||.:.:.|.
Human   463 VLGEQVQLPYQDMLQWNEAALVVPKPRVTEVHFLLRSLSDSDLLAMRRQGRFLWETYFSTADSIF 527

  Fly   421 FTTFEIIRER--LPDYPVRSSLV------------------------------------------ 441
            .|...:||.|  :|..|:|....
Human   528 NTVLAMIRTRIQIPAAPIREEAAAEIPHRSGKAAGTDPNMADNGDLDLGPVETEPPYASPRYLRN 592

  Fly   442 -----------WNSSPGALLTLPTFADSSRYMP----FLLNSMGAEPRHNYTAVIYVQIGAALGP 491
                       ||.:||.....| .......:|    ||.:..|..|..........:..||||.
Human   593 FTLTVTDFYRSWNCAPGPFHLFP-HTPFDPVLPSEAKFLGSGTGFRPIGGGAGGSGKEFQAALGG 656

  Fly   492 NA----------------ALYKLVRTITKSQFVERILVLWAADRPLPLKKRWPPTSHIPLHVISL 540
            |.                .|...:..:....::.:::|:|.:.: ||.:....|...:|:.|:
Human   657 NVPREQFTVVMLTYEREEVLMNSLERLNGLPYLNKVVVVWNSPK-LPSEDLLWPDIGVPIMVV-- 718

  Fly   541 GGSTRSQGAGPTSQTTEGRPSISQRFLPYDEIQTDAVLSLDEDAILNTDELDFAYTVWRDFPERI 605
                          .|| :.|::.||||::||:|:|:||:|:||.|..||:.|.:.|||:..:||
Human   719 --------------RTE-KNSLNNRFLPWNEIETEAILSIDDDAHLRHDEIMFGFRVWREARDRI 768

  Fly   606 VGYPARAHFWDDSKNAWGYTSKWTNYYSIVLTGAAFYHRYYNYLYTNWLSLLLLKTVQQSSNCED 670
            ||:|.|.|.||....:|.|.|.::...|:|||||||:|:||.|||:..:...:...|.:..||||
Human   769 VGFPGRYHAWDIPHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCED 833

  Fly   671 ILMNLLVSHVTRKPPIKVTQRKGYKDRETGRSPWNDPDHFIQRQSCLNTFAAVFGYMPLIRSNLR 735
            |.||.||||:|||||||||.|..::.....::..:|..||.:|..|:|.|..|:|||||:.:..|
Human   834 IAMNFLVSHITRKPPIKVTSRWTFRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFR 898

  Fly   736 MDPMLYR 742
            :|.:|::
Human   899 VDSVLFK 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttv	NP_001356963.1	Exostosin	102..393	CDD:335188	84/351 (24%)
ttv	NP_001356963.1	Glyco_transf_64	477..737	CDD:337333	98/275 (36%)
EXTL3	NP_001431.1	TPR_MLP1_2	<71..150	CDD:311742	7/31 (23%)
		Exostosin	190..500	CDD:308581	84/353 (24%)
		Glyco_transf_64	663..900	CDD:312681	93/254 (37%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	723..728		1/4 (25%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	744..746		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	829..833		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920