DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttv and EXTL2

DIOPT Version :9

Sequence 1:	NP_001356963.1	Gene:	ttv / 36614	FlyBaseID:	FBgn0265974	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001248370.1	Gene:	EXTL2 / 2135	HGNCID:	3516	Length:	338	Species:	Homo sapiens

Alignment Length:	331	Identity:	85/331 - (25%)
Similarity:	147/331 - (44%)	Gaps:	61/331 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   447 GALLT-LPTFADSSRYMPFL---LNSMGAEPRHNYTAVIYVQIGAALGPNAALYKLVRTITKSQF 507
            |||.. ||:..:....|  |   :.|.|.....::|.::.......|     |.||:........
Human    42 GALTALLPSVKEDKMLM--LRREIKSQGKSTMDSFTLIMQTYNRTDL-----LLKLLNHYQAVPN 99

  Fly   508 VERILVLW------AADRPLPLKKRWPPTSHIPLHVISLGGSTRSQGAGPTSQTTEGRPSISQRF 566
            :.:::|:|      |.|      :.|......|:.||             ..|.|..|  :..|.
Human   100 LHKVIVVWNNIGEKAPD------ELWNSLGPHPIPVI-------------FKQQTANR--MRNRL 143

  Fly   567 LPYDEIQTDAVLSLDEDAILNTDELDFAYTVWRDFPERIVGYPARAHFWDDSKNAWGYTSKWT-- 629
            ..:.|::|:|||.:|:|.:::|.:|.||::||:.||::|||:..|.|. ..|...:.|.|...
Human   144 QVFPELETNAVLMVDDDTLISTPDLVFAFSVWQQFPDQIVGFVPRKHV-STSSGIYSYGSFEMQA 207

  Fly   630 ------NYYSIVLTGAAFYHRYYNYLYTNWLSLLLLKTVQQSSNCEDILMNLLVS-HVTR----- 682
                  :.||:||.||:|::..|..|:.. ....:...:..:.||:||.||.::: |:.:
Human   208 PGSGNGDQYSMVLIGASFFNSKYLELFQR-QPAAVHALIDDTQNCDDIAMNFIIAKHIGKTSGIF 271

  Fly   683 -KPPIKVTQRKGYKDRETGRS-PWNDPDHFIQRQSCLNTFAAVFGYMPLIRSNLRMDPMLYRDPV 745
             ||   |......|:..:|.| .|:..:|.:||..|:|....::..|||..||:.:....:  |.
Human   272 VKP---VNMDNLEKETNSGYSGMWHRAEHALQRSYCINKLVNIYDSMPLRYSNIMISQFGF--PY 331

  Fly   746 SNLRKK 751
            :|.::|
Human   332 ANYKRK 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttv	NP_001356963.1	Exostosin	102..393	CDD:335188
ttv	NP_001356963.1	Glyco_transf_64	477..737	CDD:337333	73/281 (26%)
EXTL2	NP_001248370.1	Glyco_transf_64	74..321	CDD:286358	71/277 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920