Protein Alignment ttv and EXTL2

DIOPT Version :10

• Sequence 1: NP_001356963.1
• Gene: ttv / 36614
• FlyBaseID: FBgn0265974
• Length: 772
• Species: Drosophila melanogaster
• Sequence 2: NP_001248370.1
• Gene: EXTL2 / 2135
• HGNCID: 3516
• Length: 338
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 85/331 - (25%)
• Similarity: 147/331 - (44%)
• Gaps: 61/331 - (18%)

  Fly   447 GALLT-LPTFADSSRYMPFL---LNSMGAEPRHNYTAVIYVQIGAALGPNAALYKLVRTITKSQF 507
            |||.. ||:..:....|  |   :.|.|.....::|.::.......|     |.||:........
Human    42 GALTALLPSVKEDKMLM--LRREIKSQGKSTMDSFTLIMQTYNRTDL-----LLKLLNHYQAVPN 99

  Fly   508 VERILVLW------AADRPLPLKKRWPPTSHIPLHVISLGGSTRSQGAGPTSQTTEGRPSISQRF 566
            :.:::|:|      |.|      :.|......|:.||             ..|.|..|  :..|.
Human   100 LHKVIVVWNNIGEKAPD------ELWNSLGPHPIPVI-------------FKQQTANR--MRNRL 143

  Fly   567 LPYDEIQTDAVLSLDEDAILNTDELDFAYTVWRDFPERIVGYPARAHFWDDSKNAWGYTSKWT-- 629
            ..:.|::|:|||.:|:|.:::|.:|.||::||:.||::|||:..|.|. ..|...:.|.|...
Human   144 QVFPELETNAVLMVDDDTLISTPDLVFAFSVWQQFPDQIVGFVPRKHV-STSSGIYSYGSFEMQA 207

  Fly   630 ------NYYSIVLTGAAFYHRYYNYLYTNWLSLLLLKTVQQSSNCEDILMNLLVS-HVTR----- 682
                  :.||:||.||:|::..|..|:.. ....:...:..:.||:||.||.::: |:.:
Human   208 PGSGNGDQYSMVLIGASFFNSKYLELFQR-QPAAVHALIDDTQNCDDIAMNFIIAKHIGKTSGIF 271

  Fly   683 -KPPIKVTQRKGYKDRETGRS-PWNDPDHFIQRQSCLNTFAAVFGYMPLIRSNLRMDPMLYRDPV 745
             ||   |......|:..:|.| .|:..:|.:||..|:|....::..|||..||:.:....:  |.
Human   272 VKP---VNMDNLEKETNSGYSGMWHRAEHALQRSYCINKLVNIYDSMPLRYSNIMISQFGF--PY 331

  Fly   746 SNLRKK 751
            :|.::|
Human   332 ANYKRK 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ttv	NP_001356963.1	Exostosin	102..393	CDD:397245
		Glyco_transf_64	477..737	CDD:430488	73/281 (26%)
EXTL2	NP_001248370.1	Glyco_transf_64	74..325	CDD:430488	73/281 (26%)