Protein Alignment ttv and EXTL1

DIOPT Version :10

• Sequence 1: NP_001356963.1
• Gene: ttv / 36614
• FlyBaseID: FBgn0265974
• Length: 772
• Species: Drosophila melanogaster
• Sequence 2: NP_004446.2
• Gene: EXTL1 / 2134
• HGNCID: 3515
• Length: 676
• Species: Homo sapiens
• Alignment Length: 779
• Identity: 295/779 - (37%)
• Similarity: 416/779 - (53%)
• Gaps: 128/779 - (16%)

  Fly     1 MQA--KKRYILVFVSCAFLAYAYFGGY---RLKVSPLRPRRAQHESAKDGGVQPHEQLPSFLGAH 60
            ||:  :::.:.:.:|.::|.....||:   ||.:.| |||    ..|..|       .|.:|.|
Human     1 MQSWRRRKSLWLALSASWLLLVLLGGFSLLRLALPP-RPR----PGASQG-------WPRWLDA- 52

  Fly    61 DMQELQLLQS-NQSKSLDSSKHLVTRKP---DCRMETCFDFTRCY-DRFLVYIYPPEPLNSLGAA 120
                 :|||| :|...|........:.|   .|..|:|||.::|. |...|::||        |.
Human    53 -----ELLQSFSQPGELPEDAVSPPQAPHGGSCNWESCFDTSKCRGDGLKVFVYP--------AV 104

  Fly   121 PPTSANYQKILTAIQESRYYTSDPTAACLFVLGIDTLDRDSLSEDYVRNVPSRLARLP-YWNNGR 184
            ...|..:::||.:|:.||:||..|..|||.:|    |..|:.:        ...:.:| .||.||
Human   105 GTISETHRRILASIEGSRFYTFSPAGACLLLL----LSLDAQT--------GECSSMPLQWNRGR 157

  Fly   185 NHIIFNLYSGTWPDYAENSLGFDAGEAILAKASMGVLQLRHGFDVSIPLFHKQFPLRAGATGTVQ 249
            ||::..|:....|      ..|..|:|::|:||..|...|.||||::|...:..|||.||.|.::
Human   158 NHLVLRLHPAPCP------RTFQLGQAMVAEASPTVDSFRPGFDVALPFLPEAHPLRGGAPGQLR 216

  Fly   250 SNNFPANKKYLLAFKGKRYVHGIGSETRNSLFHLHNGRDMVLVTTCRHGKS---WRELQDNRCDE 311
            .:: |.....|||.:.:|.    |..|.::                  |.|   |    |.||::
Human   217 QHS-PQPGVALLALEEERG----GWRTADT------------------GSSACPW----DGRCEQ 254

  Fly   312 DNREYDRYDYETLLQNSTFCLVPRGRRLGSFRFLEALQAGCIPVLLSNAWVLPFESKIDWKQAAI 376
            |.........|| |.|:||||:...|...:.|||:||||||||||||..|.|||...|||.:|||
Human   255 DPGPGQTQRQET-LPNATFCLISGHRPEAASRFLQALQAGCIPVLLSPRWELPFSEVIDWTKAAI 318

  Fly   377 WADERLLLQVPDIVRSIPAERIFALRQQTQVLWERYFGSIEKIVFTTFEIIRERLPDYPVRSSLV 441
            .|||||.|||...::.:...|:.|||||||.||:.||.|:||::.||.|:|::|:.......||:
Human   319 VADERLPLQVLAALQEMSPARVLALRQQTQFLWDAYFSSVEKVIHTTLEVIQDRIFGTSAHPSLL 383

  Fly   442 WNSSPGALLTLPTFADSSRYMPFLLNSMGAEPRHNYTAVIYVQIGAALGPNAALYKLVRTITKSQ 506
            |||.|||||.|.||:.|.:..||.....|:.|...::|:|:|.     .|.....||::.:..||
Human   384 WNSPPGALLALSTFSTSPQDFPFYYLQQGSRPEGRFSALIWVG-----PPGQPPLKLIQAVAGSQ 443

  Fly   507 FVERILVLWAADRPLPLKKRWPPTSHIPLHVISLGGSTRSQGAGPTSQTTEGRPSISQRFLPYDE 571
            ...:|||||:.:||||  .|||.|: :||.||                  :|...:|.||.||..
Human   444 HCAQILVLWSNERPLP--SRWPETA-VPLTVI------------------DGHRKVSDRFYPYST 487

  Fly   572 IQTDAVLSLDEDAILNTDELDFAYTVWRDFPERIVGYPARAHFWDDSKNAWGYTSKWTNYYSIVL 636
            |:|||:||||..:.|:|.|:|||:.||:.||||:||:...:||||::...||||::.||.:|:||
Human   488 IRTDAILSLDARSSLSTSEVDFAFLVWQSFPERMVGFLTSSHFWDEAHGGWGYTAERTNEFSMVL 552

  Fly   637 TGAAFYHRYYNYLYTNWLSLLLLKTVQQSSNCEDILMNLLVSHVTRKPPIKV---TQRKGYKDRE 698
            |.||||||||:.|:|:.|...|.....::..|.|:|||.:|:.||:.|||||   .||:......
Human   553 TTAAFYHRYYHTLFTHSLPKALRTLADEAPTCVDVLMNFIVAAVTKLPPIKVPYGKQRQEAAPLA 617

  Fly   699 TG------RSPWNDPDHFIQRQSCLNTFAAVFGYMPLIRSNLRMDPMLYRDPVSNLRKKYRQIE 756
            .|      :.|...||       |:|..||.||:|||:.|.||:||:|::||||..|||||.:|
Human   618 PGGPGPRPKPPAPAPD-------CINQIAAAFGHMPLLSSRLRLDPVLFKDPVSVQRKKYRSLE 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ttv	NP_001356963.1	Exostosin	102..393	CDD:397245	104/294 (35%)
		Glyco_transf_64	477..737	CDD:430488	110/268 (41%)
EXTL1	NP_004446.2	Exostosin	92..335	CDD:397245	104/296 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..264		8/47 (17%)
		Glyco_transf_64	419..655	CDD:430488	110/268 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	610..631		3/20 (15%)