DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ttv and EXT1

DIOPT Version :9

Sequence 1:NP_001356963.1 Gene:ttv / 36614 FlyBaseID:FBgn0265974 Length:772 Species:Drosophila melanogaster
Sequence 2:NP_000118.2 Gene:EXT1 / 2131 HGNCID:3512 Length:746 Species:Homo sapiens


Alignment Length:776 Identity:414/776 - (53%)
Similarity:529/776 - (68%) Gaps:52/776 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MQAKKRYILVFV--SCAFLAYAYFGGYRLKVSPLRPRRAQHESAKDGGVQPHEQLPSFLGAHDMQ 63
            |||||||.::..  ||..|.: ||||.:.:.|....||.:| |.::|   .|...|.........
Human     1 MQAKKRYFILLSAGSCLALLF-YFGGLQFRASRSHSRREEH-SGRNG---LHHPSPDHFWPRFPD 60

  Fly    64 ELQ-LLQSNQSKSLDSSKHLVTR-KPD----------CRMETCFDFTRC-YDRFLVYIYPPEPLN 115
            .|: .:..:|.::.|||.|:..| |.|          ||||:|||||.| .:.|.||:||.:...
Human    61 ALRPFVPWDQLENEDSSVHISPRQKRDANSSIYKGKKCRMESCFDFTLCKKNGFKVYVYPQQKGE 125

  Fly   116 SLGAAPPTSANYQKILTAIQESRYYTSDPTAACLFVLGIDTLDRDSLSEDYVRNVPSRLARLPYW 180
            .:      :.:||.||.||:.||:|||||:.||||||.:||||||.||..||.|:.|::..|..|
Human   126 KI------AESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQSLHLW 184

  Fly   181 NNGRNHIIFNLYSGTWPDYAENSLGFDAGEAILAKASMGVLQLRHGFDVSIPLFHKQFPLRAGAT 245
            ||||||:||||||||||||.|: :|||.|:|:|||||:.....|..||||||||.|..|...|..
Human   185 NNGRNHLIFNLYSGTWPDYTED-VGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGGER 248

  Fly   246 GTVQSNNFPANKKYLLAFKGKRYVHGIGSETRNSLFHLHNGRDMVLVTTCRHGKSWRELQDNRCD 310
            |.::.|..|..:||:|.||||||:.||||:|||:|:|:|||.|:||:|||:|||.|::.:|:|||
Human   249 GFLKFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVVLLTTCKHGKDWQKHKDSRCD 313

  Fly   311 EDNREYDRYDYETLLQNSTFCLVPRGRRLGSFRFLEALQAGCIPVLLSNAWVLPFESKIDWKQAA 375
            .||.||::|||..:|.|:||||||||||||||||||||||.|:||:|||.|.|||...|:|.|||
Human   314 RDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEVINWNQAA 378

  Fly   376 IWADERLLLQVPDIVRSIPAERIFALRQQTQVLWERYFGSIEKIVFTTFEIIRERLPDYPVRSSL 440
            :..|||||||:|..:|||..::|.|||||||.|||.||.|:||||.||.|||::|:..:..|:||
Human   379 VIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRNSL 443

  Fly   441 VWNSSPGALLTLPTFADSSRYMPFLLNSMGAEPRHNYTAVIYVQIGAALGPNAALYKLVRTITKS 505
            :||..||.|..||.::......|:...::|.:|...:||||:. :...:..:..:.||:....||
Human   444 IWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHA-VTPLVSQSQPVLKLLVAAAKS 507

  Fly   506 QFVERILVLWAADRPLPLKKRWPPTSHIPLHVISLGGSTRSQGAGPTSQTTEGRPSI-SQRFLPY 569
            |:..:|:|||..|:|||.|.|||.|: :|:.||                  ||...: |.|||||
Human   508 QYCAQIIVLWNCDKPLPAKHRWPATA-VPVVVI------------------EGESKVMSSRFLPY 553

  Fly   570 DEIQTDAVLSLDEDAILNTDELDFAYTVWRDFPERIVGYPARAHFWDDSKNAWGYTSKWTNYYSI 634
            |.|.||||||||||.:|:|.|:|||:|||:.|||||||||||:||||:||..|||||||||.||:
Human   554 DNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDNSKERWGYTSKWTNDYSM 618

  Fly   635 VLTGAAFYHRYYNYLYTNWLSLLLLKTVQQSSNCEDILMNLLVSHVTRKPPIKVTQRKGYKDRET 699
            ||||||.||:||:|||:::|...|...|.|.:||||||||.|||.||:.|||||||:|.||:...
Human   619 VLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKETMM 683

  Fly   700 GR----SPWNDPDHFIQRQSCLNTFAAVFGYMPLIRSNLRMDPMLYRDPVSNLRKKYRQIE 756
            |:    |.|.|||||.|||||:||||:.|||||||.|.:|:||:|::|.||.||||||.||
Human   684 GQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKYRDIE 744

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ttvNP_001356963.1 Exostosin 102..393 CDD:335188 172/290 (59%)
Glyco_transf_64 477..737 CDD:337333 148/264 (56%)
EXT1NP_000118.2 Exostosin 110..396 CDD:308581 172/292 (59%)
Glyco_transf_64 480..725 CDD:312681 148/264 (56%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:Q9ES89 544..549 1/4 (25%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:Q9ES89 565..567 1/1 (100%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:Q9ES89 650..654 2/3 (67%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:Q9ES89 688..701 7/12 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 371 1.000 Domainoid score I907
eggNOG 1 0.900 - - E1_KOG1021
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H30957
Inparanoid 1 1.050 800 1.000 Inparanoid score I507
Isobase 1 0.950 - 0 Normalized mean entropy S3418
OMA 1 1.010 - - QHG48090
OrthoDB 1 1.010 - - D314330at33208
OrthoFinder 1 1.000 - - FOG0005645
OrthoInspector 1 1.000 - - oto89923
orthoMCL 1 0.900 - - OOG6_104903
Panther 1 1.100 - - O PTHR11062
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2521
SonicParanoid 1 1.000 - - X187
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

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