Protein Alignment ttv and EXT1

DIOPT Version :10

• Sequence 1: NP_001356963.1
• Gene: ttv / 36614
• FlyBaseID: FBgn0265974
• Length: 772
• Species: Drosophila melanogaster
• Sequence 2: NP_000118.2
• Gene: EXT1 / 2131
• HGNCID: 3512
• Length: 746
• Species: Homo sapiens
• Alignment Length: 776
• Identity: 414/776 - (53%)
• Similarity: 529/776 - (68%)
• Gaps: 52/776 - (6%)

  Fly     1 MQAKKRYILVFV--SCAFLAYAYFGGYRLKVSPLRPRRAQHESAKDGGVQPHEQLPSFLGAHDMQ 63
            |||||||.::..  ||..|.: ||||.:.:.|....||.:| |.::|   .|...|.........
Human     1 MQAKKRYFILLSAGSCLALLF-YFGGLQFRASRSHSRREEH-SGRNG---LHHPSPDHFWPRFPD 60

  Fly    64 ELQ-LLQSNQSKSLDSSKHLVTR-KPD----------CRMETCFDFTRC-YDRFLVYIYPPEPLN 115
            .|: .:..:|.::.|||.|:..| |.|          ||||:|||||.| .:.|.||:||.:...
Human    61 ALRPFVPWDQLENEDSSVHISPRQKRDANSSIYKGKKCRMESCFDFTLCKKNGFKVYVYPQQKGE 125

  Fly   116 SLGAAPPTSANYQKILTAIQESRYYTSDPTAACLFVLGIDTLDRDSLSEDYVRNVPSRLARLPYW 180
            .:      :.:||.||.||:.||:|||||:.||||||.:||||||.||..||.|:.|::..|..|
Human   126 KI------AESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQSLHLW 184

  Fly   181 NNGRNHIIFNLYSGTWPDYAENSLGFDAGEAILAKASMGVLQLRHGFDVSIPLFHKQFPLRAGAT 245
            ||||||:||||||||||||.|: :|||.|:|:|||||:.....|..||||||||.|..|...|..
Human   185 NNGRNHLIFNLYSGTWPDYTED-VGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGGER 248

  Fly   246 GTVQSNNFPANKKYLLAFKGKRYVHGIGSETRNSLFHLHNGRDMVLVTTCRHGKSWRELQDNRCD 310
            |.::.|..|..:||:|.||||||:.||||:|||:|:|:|||.|:||:|||:|||.|::.:|:|||
Human   249 GFLKFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVVLLTTCKHGKDWQKHKDSRCD 313

  Fly   311 EDNREYDRYDYETLLQNSTFCLVPRGRRLGSFRFLEALQAGCIPVLLSNAWVLPFESKIDWKQAA 375
            .||.||::|||..:|.|:||||||||||||||||||||||.|:||:|||.|.|||...|:|.|||
Human   314 RDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEVINWNQAA 378

  Fly   376 IWADERLLLQVPDIVRSIPAERIFALRQQTQVLWERYFGSIEKIVFTTFEIIRERLPDYPVRSSL 440
            :..|||||||:|..:|||..::|.|||||||.|||.||.|:||||.||.|||::|:..:..|:||
Human   379 VIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRNSL 443

  Fly   441 VWNSSPGALLTLPTFADSSRYMPFLLNSMGAEPRHNYTAVIYVQIGAALGPNAALYKLVRTITKS 505
            :||..||.|..||.::......|:...::|.:|...:||||:. :...:..:..:.||:....||
Human   444 IWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHA-VTPLVSQSQPVLKLLVAAAKS 507

  Fly   506 QFVERILVLWAADRPLPLKKRWPPTSHIPLHVISLGGSTRSQGAGPTSQTTEGRPSI-SQRFLPY 569
            |:..:|:|||..|:|||.|.|||.|: :|:.||                  ||...: |.|||||
Human   508 QYCAQIIVLWNCDKPLPAKHRWPATA-VPVVVI------------------EGESKVMSSRFLPY 553

  Fly   570 DEIQTDAVLSLDEDAILNTDELDFAYTVWRDFPERIVGYPARAHFWDDSKNAWGYTSKWTNYYSI 634
            |.|.||||||||||.:|:|.|:|||:|||:.|||||||||||:||||:||..|||||||||.||:
Human   554 DNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDNSKERWGYTSKWTNDYSM 618

  Fly   635 VLTGAAFYHRYYNYLYTNWLSLLLLKTVQQSSNCEDILMNLLVSHVTRKPPIKVTQRKGYKDRET 699
            ||||||.||:||:|||:::|...|...|.|.:||||||||.|||.||:.|||||||:|.||:...
Human   619 VLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKETMM 683

  Fly   700 GR----SPWNDPDHFIQRQSCLNTFAAVFGYMPLIRSNLRMDPMLYRDPVSNLRKKYRQIE 756
            |:    |.|.|||||.|||||:||||:.|||||||.|.:|:||:|::|.||.||||||.||
Human   684 GQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKYRDIE 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ttv	NP_001356963.1	Exostosin	102..393	CDD:397245	172/290 (59%)
		Glyco_transf_64	477..737	CDD:430488	148/264 (56%)
EXT1	NP_000118.2	Exostosin	110..396	CDD:397245	172/292 (59%)
		Glyco_transf_64	480..725	CDD:430488	148/264 (56%)