DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttv and Ext2

DIOPT Version :9

Sequence 1:	NP_001356963.1	Gene:	ttv / 36614	FlyBaseID:	FBgn0265974	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	XP_006498793.1	Gene:	Ext2 / 14043	MGIID:	108050	Length:	773	Species:	Mus musculus

Alignment Length:	797	Identity:	271/797 - (34%)
Similarity:	397/797 - (49%)	Gaps:	134/797 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQAKKR-YILVFVSCAFLAYAYFGGYRLKVSPLRPRRAQHESAKDGGVQPHEQLPSFLGAHDMQE 64
            |:.|.| |.:...|...|.....|.::.....:       ||:.||||:          ...::|
Mouse    73 MKTKHRIYYVTLFSIVLLGLIATGMFQFWPHSI-------ESSSDGGVE----------KRSIRE 120

  Fly    65 LQLLQSNQSKSLDSSKHLVTRKP-------DCRMETCFDFTRC----YDRFLVYIYPPEPLNSLG 118
            :.:::            |.|..|       .|||.||||..||    .::..|||||.:......
Mouse   121 VPVVR------------LPTDSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYPLKKYVDDA 173

  Fly   119 AAPPTSA---NYQKILTAIQESRYYTSDPTAACLFVLGIDTLDRDSLSEDYVRNVPSRLARLPYW 180
            ..|.:||   .|.::||||.:|.|||.|...|||||..||.|:::.|.   ::.....||:|..|
Mouse   174 GVPVSSAISREYNELLTAISDSDYYTDDINRACLFVPSIDVLNQNPLR---IKETAQALAQLSRW 235

  Fly   181 NNGRNHIIFNLYSGTWPDYAENSLGFDAGEAILAKASMGVLQLRHGFDVSIPLFHKQFPLRAGAT 245
            :.|.||::||:..|..||| ..:|......|:||.........|.|:|||||:|.   ||.|
Mouse   236 DRGTNHLLFNMLPGAPPDY-NTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVFS---PLSA--- 293

  Fly   246 GTVQSNNFPANKKYLLAFKGKRYVHGIGSETRNSLFHLHNGRDMVL--VTTCRHG-KSWRELQDN 307
            ........|..::|.| ...:..:|....|...:|...|....:||  .|....| .|.|:
Mouse   294 EMALPEKAPGPRRYFL-LSSQMAIHPEYREELEALQAKHQESVLVLDKCTNLSEGVLSVRK---- 353

  Fly   308 RCDEDNREYDRYDYETLLQNSTFCLVPRGRRLGSFRFLEALQAGCIPVLLSNAWVLPFESKIDWK 372
            ||    .::..:||..:||.:|||.|.||.|||.....:.|||||:||:::::::|||...:|||
Mouse   354 RC----HQHQVFDYPQVLQEATFCTVLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWK 414

  Fly   373 QAAIWADERLLLQVPDIVRSIPAERIFALRQQTQVLWERYFGSIEKIVFTTFEIIRERLPDYPVR 437
            :|::...|..:..|..|:::||..:|..:::|.:..||.||.||:.|...|.:||.:|:..|...
Mouse   415 RASVVVPEEKMSDVYSILQNIPQRQIEEMQRQARWFWEAYFQSIKAIALATLQIINDRIYPYAAI 479

  Fly   438 SSLVWNSSPG---ALLTLPTFADSSRYMPFLLNSMGAEPR-HNYTAVI--YVQIGAALGPNAALY 496
            |...||..|.   |.::.|.|      :|.:      .|: ..:||::  |.::       .:|:
Mouse   480 SYEEWNDPPAVKWASVSNPLF------LPLI------PPQSQGFTAIVLTYDRV-------ESLF 525

  Fly   497 KLVRTITKSQFVERILVLWAADRPLPLKKRWPPTSHIPLHVISLGGSTRSQGAGPTSQTTEGRPS 561
            :::..::|...:.::||:|......|.::...|...:||.|:               :|.|.:
Mouse   526 RVITEVSKVPSLSKLLVVWNNQNKNPPEESLWPKIRVPLKVV---------------RTAENK-- 573

  Fly   562 ISQRFLPYDEIQTDAVLSLDEDAI-LNTDELDFAYTVWRDFPERIVGYPARAHFWDDSKNAWGYT 625
            :|.||.|||||:|:|||::|:|.| |.:|||.|.|.|||:||:|:||||.|.|.||...|.|.|.
Mouse   574 LSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYE 638

  Fly   626 SKWTNYYSIVLTGAAFYHRYYNYLYT--------NWLSLLLLKTVQQSSNCEDILMNLLVSHVTR 682
            |:|||..|:|||||||||:|:|||||        ||        |....|||||.||.||::||.
Mouse   639 SEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNW--------VDTHMNCEDIAMNFLVANVTG 695

  Fly   683 KPPIKVTQRKGYKDRE----TGRSPWNDPDHFIQRQSCLNTFAAVFGYMPLIRSNLRMDPMLYRD 743
            |..||||.||.:|..|    .|.|  .|..|.::|..|:|.||:|||.|||.....|.||:||:|
Mouse   696 KAVIKVTPRKKFKCPECTAIDGLS--LDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKD 758

  Fly   744 PVSNLRKKYRQIELVGS 760
               :..:|.:....:||
Mouse   759 ---DFPEKLKSFPNIGS 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttv	NP_001356963.1	Exostosin	102..393	CDD:335188	100/296 (34%)
ttv	NP_001356963.1	Glyco_transf_64	477..737	CDD:337333	112/274 (41%)
Ext2	XP_006498793.1	Exostosin	155..435	CDD:367297	100/298 (34%)
Ext2	XP_006498793.1	Glyco_transf_64	511..752	CDD:370389	112/274 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910