DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ttv and Ext1

DIOPT Version :9

Sequence 1:	NP_001356963.1	Gene:	ttv / 36614	FlyBaseID:	FBgn0265974	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_034292.2	Gene:	Ext1 / 14042	MGIID:	894663	Length:	746	Species:	Mus musculus

Alignment Length:	778	Identity:	416/778 - (53%)
Similarity:	531/778 - (68%)	Gaps:	56/778 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQAKKRYILVFV--SCAFLAYAYFGGYRLKVSPLRPRRAQHESAKDGGVQPHEQ--LPSFLGAHD 61
            |||||||.::..  ||..|.: ||||.:.:.|....||.:| |.::|..||...  .|.|..|
Mouse     1 MQAKKRYFILLSAGSCLALLF-YFGGVQFRASRSHSRREEH-SGRNGLHQPSPDHFWPRFPDA-- 61

  Fly    62 MQELQ-LLQSNQSKSLDSSKHLVTR-KPD----------CRMETCFDFTRC-YDRFLVYIYPPEP 113
               |: ....:|.::.|||.|:..| |.|          ||||:|||||.| .:.|.||:||.:.
Mouse    62 ---LRPFFPWDQLENEDSSVHISPRQKRDANSSIYKGKKCRMESCFDFTLCKKNGFKVYVYPQQK 123

  Fly   114 LNSLGAAPPTSANYQKILTAIQESRYYTSDPTAACLFVLGIDTLDRDSLSEDYVRNVPSRLARLP 178
            ...:      :.:||.||.||:.||:|||||:.||||||.:||||||.||..||.|:.|::..|.
Mouse   124 GEKI------AESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQSLH 182

  Fly   179 YWNNGRNHIIFNLYSGTWPDYAENSLGFDAGEAILAKASMGVLQLRHGFDVSIPLFHKQFPLRAG 243
            .|||||||:||||||||||||.|: :|||.|:|:|||||:.....|..||||||||.|..|...|
Mouse   183 LWNNGRNHLIFNLYSGTWPDYTED-VGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGG 246

  Fly   244 ATGTVQSNNFPANKKYLLAFKGKRYVHGIGSETRNSLFHLHNGRDMVLVTTCRHGKSWRELQDNR 308
            ..|.::.|..|..:||:|.||||||:.||||:|||:|:|:|||.|::|:|||:|||.|::.:|:|
Mouse   247 ERGFLKFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVLLLTTCKHGKDWQKHKDSR 311

  Fly   309 CDEDNREYDRYDYETLLQNSTFCLVPRGRRLGSFRFLEALQAGCIPVLLSNAWVLPFESKIDWKQ 373
            ||.||.||::|||..:|.|:||||||||||||||||||||||.|:||:|||.|.|||...|:|.|
Mouse   312 CDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEVINWNQ 376

  Fly   374 AAIWADERLLLQVPDIVRSIPAERIFALRQQTQVLWERYFGSIEKIVFTTFEIIRERLPDYPVRS 438
            ||:..|||||||:|..:|||..::|.|||||||.|||.||.|:||||.||.|||::|:..:..|:
Mouse   377 AAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRN 441

  Fly   439 SLVWNSSPGALLTLPTFADSSRYMPFLLNSMGAEPRHNYTAVIYVQIGAALGPNAALYKLVRTIT 503
            ||:||..||.|..||.::......|:...::|.:|...:||||:. :...:..:..:.||:....
Mouse   442 SLIWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHA-VTPLVSQSQPVLKLLVAAA 505

  Fly   504 KSQFVERILVLWAADRPLPLKKRWPPTSHIPLHVISLGGSTRSQGAGPTSQTTEGRPSI-SQRFL 567
            |||:..:|:|||..|:|||.|.|||.|: :|:.||                  ||...: |.|||
Mouse   506 KSQYCAQIIVLWNCDKPLPAKHRWPATA-VPVIVI------------------EGESKVMSSRFL 551

  Fly   568 PYDEIQTDAVLSLDEDAILNTDELDFAYTVWRDFPERIVGYPARAHFWDDSKNAWGYTSKWTNYY 632
            |||.|.||||||||||.:|:|.|:|||:|||:.|||||||||||:||||:||..|||||||||.|
Mouse   552 PYDNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDNSKERWGYTSKWTNDY 616

  Fly   633 SIVLTGAAFYHRYYNYLYTNWLSLLLLKTVQQSSNCEDILMNLLVSHVTRKPPIKVTQRKGYKDR 697
            |:||||||.||:||:|||:::|...|...|.|.:||||||||.|||.||:.|||||||:|.||:.
Mouse   617 SMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKET 681

  Fly   698 ETGR----SPWNDPDHFIQRQSCLNTFAAVFGYMPLIRSNLRMDPMLYRDPVSNLRKKYRQIE 756
            ..|:    |.|.|||||.|||||:||||:.|||||||.|.:|:||:|::|.||.||||||.||
Mouse   682 MMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKYRDIE 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttv	NP_001356963.1	Exostosin	102..393	CDD:335188	171/290 (59%)
ttv	NP_001356963.1	Glyco_transf_64	477..737	CDD:337333	148/264 (56%)
Ext1	NP_034292.2	Exostosin	110..396	CDD:397245	171/292 (59%)
		Glyco_transf_64	480..725	CDD:401264	148/264 (56%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	544..549		1/4 (25%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	565..567		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	650..654		2/3 (67%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	688..701		7/12 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	370	1.000	Domainoid score	I906
eggNOG	1	0.900	-	-		E1_KOG1021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30957
Inparanoid	1	1.050	800	1.000	Inparanoid score	I501
Isobase	1	0.950	-	0	Normalized mean entropy	S3418
OMA	1	1.010	-	-		QHG48090
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	1	1.000	-	-		FOG0005645
OrthoInspector	1	1.000	-	-		oto93500
orthoMCL	1	0.900	-	-		OOG6_104903
Panther	1	1.100	-	-	O	PTHR11062
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2521
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820