Protein Alignment ttv and Ext1

DIOPT Version :10

• Sequence 1: NP_001356963.1
• Gene: ttv / 36614
• FlyBaseID: FBgn0265974
• Length: 772
• Species: Drosophila melanogaster
• Sequence 2: NP_034292.2
• Gene: Ext1 / 14042
• MGIID: 894663
• Length: 746
• Species: Mus musculus
• Alignment Length: 778
• Identity: 416/778 - (53%)
• Similarity: 531/778 - (68%)
• Gaps: 56/778 - (7%)

  Fly     1 MQAKKRYILVFV--SCAFLAYAYFGGYRLKVSPLRPRRAQHESAKDGGVQPHEQ--LPSFLGAHD 61
            |||||||.::..  ||..|.: ||||.:.:.|....||.:| |.::|..||...  .|.|..|
Mouse     1 MQAKKRYFILLSAGSCLALLF-YFGGVQFRASRSHSRREEH-SGRNGLHQPSPDHFWPRFPDA-- 61

  Fly    62 MQELQ-LLQSNQSKSLDSSKHLVTR-KPD----------CRMETCFDFTRC-YDRFLVYIYPPEP 113
               |: ....:|.::.|||.|:..| |.|          ||||:|||||.| .:.|.||:||.:.
Mouse    62 ---LRPFFPWDQLENEDSSVHISPRQKRDANSSIYKGKKCRMESCFDFTLCKKNGFKVYVYPQQK 123

  Fly   114 LNSLGAAPPTSANYQKILTAIQESRYYTSDPTAACLFVLGIDTLDRDSLSEDYVRNVPSRLARLP 178
            ...:      :.:||.||.||:.||:|||||:.||||||.:||||||.||..||.|:.|::..|.
Mouse   124 GEKI------AESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQSLH 182

  Fly   179 YWNNGRNHIIFNLYSGTWPDYAENSLGFDAGEAILAKASMGVLQLRHGFDVSIPLFHKQFPLRAG 243
            .|||||||:||||||||||||.|: :|||.|:|:|||||:.....|..||||||||.|..|...|
Mouse   183 LWNNGRNHLIFNLYSGTWPDYTED-VGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGG 246

  Fly   244 ATGTVQSNNFPANKKYLLAFKGKRYVHGIGSETRNSLFHLHNGRDMVLVTTCRHGKSWRELQDNR 308
            ..|.::.|..|..:||:|.||||||:.||||:|||:|:|:|||.|::|:|||:|||.|::.:|:|
Mouse   247 ERGFLKFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVLLLTTCKHGKDWQKHKDSR 311

  Fly   309 CDEDNREYDRYDYETLLQNSTFCLVPRGRRLGSFRFLEALQAGCIPVLLSNAWVLPFESKIDWKQ 373
            ||.||.||::|||..:|.|:||||||||||||||||||||||.|:||:|||.|.|||...|:|.|
Mouse   312 CDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEVINWNQ 376

  Fly   374 AAIWADERLLLQVPDIVRSIPAERIFALRQQTQVLWERYFGSIEKIVFTTFEIIRERLPDYPVRS 438
            ||:..|||||||:|..:|||..::|.|||||||.|||.||.|:||||.||.|||::|:..:..|:
Mouse   377 AAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRN 441

  Fly   439 SLVWNSSPGALLTLPTFADSSRYMPFLLNSMGAEPRHNYTAVIYVQIGAALGPNAALYKLVRTIT 503
            ||:||..||.|..||.::......|:...::|.:|...:||||:. :...:..:..:.||:....
Mouse   442 SLIWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHA-VTPLVSQSQPVLKLLVAAA 505

  Fly   504 KSQFVERILVLWAADRPLPLKKRWPPTSHIPLHVISLGGSTRSQGAGPTSQTTEGRPSI-SQRFL 567
            |||:..:|:|||..|:|||.|.|||.|: :|:.||                  ||...: |.|||
Mouse   506 KSQYCAQIIVLWNCDKPLPAKHRWPATA-VPVIVI------------------EGESKVMSSRFL 551

  Fly   568 PYDEIQTDAVLSLDEDAILNTDELDFAYTVWRDFPERIVGYPARAHFWDDSKNAWGYTSKWTNYY 632
            |||.|.||||||||||.:|:|.|:|||:|||:.|||||||||||:||||:||..|||||||||.|
Mouse   552 PYDNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDNSKERWGYTSKWTNDY 616

  Fly   633 SIVLTGAAFYHRYYNYLYTNWLSLLLLKTVQQSSNCEDILMNLLVSHVTRKPPIKVTQRKGYKDR 697
            |:||||||.||:||:|||:::|...|...|.|.:||||||||.|||.||:.|||||||:|.||:.
Mouse   617 SMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKET 681

  Fly   698 ETGR----SPWNDPDHFIQRQSCLNTFAAVFGYMPLIRSNLRMDPMLYRDPVSNLRKKYRQIE 756
            ..|:    |.|.|||||.|||||:||||:.|||||||.|.:|:||:|::|.||.||||||.||
Mouse   682 MMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKYRDIE 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ttv	NP_001356963.1	Exostosin	102..393	CDD:397245	171/290 (59%)
		Glyco_transf_64	477..737	CDD:430488	148/264 (56%)
Ext1	NP_034292.2	Exostosin	110..396	CDD:397245	171/292 (59%)
		Glyco_transf_64	480..725	CDD:430488	148/264 (56%)