DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asx and ASXL3

DIOPT Version :9

Sequence 1:	NP_001260969.1	Gene:	Asx / 36612	FlyBaseID:	FBgn0261823	Length:	1670	Species:	Drosophila melanogaster
Sequence 2:	XP_005258413.1	Gene:	ASXL3 / 80816	HGNCID:	29357	Length:	2249	Species:	Homo sapiens

Alignment Length:	2379	Identity:	440/2379 - (18%)
Similarity:	731/2379 - (30%)	Gaps:	965/2379 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KTITPDTTTT-----TSSQHQQLLIPQADQHHQPMLQQQSLLAAPPPTMIMEHVNLVDDDEKDPL 61
            |.:|.:.::|     |::..|..|:....||.:..|:|
Human   123 KQVTDEASSTRDSSLTNTAVQSKLVSSFQQHTKKALKQ--------------------------- 160

  Fly    62 ALEQLE-----VSPSTKHTHSLRRHLPRIIVKPIPPEKKPMAPSEEAAVSTAPAPPTRLICSRRI 121
            ||.|.:     ||.....|      :||:::.|:                             ::
Human   161 ALRQQQKRRNGVSMMVNKT------VPRVVLTPL-----------------------------KV 190

  Fly   122 QQQQQVKAAAAAAAAAAAAAAAAAAAAQAQATSSYPSAISPGSKAGTSQASTMREVLASIPGFSV 186
            ..:|             :.:.:.:.:...:|.|| ...:..|.|:.|.:.::..          :
Human   191 SDEQ-------------SDSPSGSESKNGEADSS-DKEMKHGQKSPTGKQTSQH----------L 231

  Fly   187 KPRRRSNKKLTTAAQIEQTKDGKIDLETPDSILASTNLRALLNKQTFSLLPPLYQYNLIQLLPSV 251
            |..::|.     ...::.||...||:|||.|||.:||||||:||.||:.||..:|..|:.|||.|
Human   232 KRLKKSG-----LGHLKWTKAEDIDIETPGSILVNTNLRALINKHTFASLPQHFQQYLLLLLPEV 291

  Fly   252 DREASELEQPSSSASGGSPSEAIRLSASCLNNEFFARACLEWRERLSEGEFTPENQLKLKTEAER 316
            ||:.            ||.. .:|||.|.|||||||.|...|::||:|||||||.||:::.|.|:
Human   292 DRQM------------GSDG-ILRLSTSALNNEFFAYAAQGWKQRLAEGEFTPEMQLRIRQEIEK 343

  Fly   317 EKNKLDPWKLKHFEPFWGEKNSRGKDKDKLESDCKNQKLSASIKSEPKPPATSQQKPLQQATCDN 381
            || |.:|||.|.||.|:|||....:::              |:|....|.....|.
Human   344 EK-KTEPWKEKFFERFYGEKLGMSREE--------------SVKLTTGPNNAGAQS--------- 384

  Fly   382 ETELKFDLSTKCETTSAKTTVAVAVAD------KSSTFPPTG-----------SQNNVLNEQQRR 429
                    |:.|.|:....:...|:|:      ||...|..|           ...:::.|.:..
Human   385 --------SSSCGTSGLPVSAQTALAEQQPKSMKSPASPEPGFCATLCPMVEIPPKDIMAELESE 441

  Fly   430 VLKRPSSSPSQR---KQAPTTIATINLDDDLDELPSTSKDS-------KQPKMDEIVPNASGNVV 484
            .:..|..|..|.   ::..|:|.... |::...:|..|:::       ::|::.....|....|:
Human   442 DILIPEESVIQEEIAEEVETSICECQ-DENHKTIPEFSEEAESLTNSHEEPQIAPPEDNLESCVM 505

  Fly   485 AAPMVDVVDHSAVEMKIKDEQQHQRQHQPLI---NSTCDKIEPSECSKEMIVAMKQVDSKEDVDS 546
            ...:::.:.|  :|:||:.:.:..::...::   ...||.:.||..|      |..|...|..:|
Human   506 MNDVLETLPH--IEVKIEGKSESPQEEMTVVIDQLEVCDSLIPSTSS------MTHVSDTEHKES 562

  Fly   547 IASAAAMPAIAAVTPHTPK-------PEALAPNPDVANQFVSYLQNVELAAETKAPL-------- 596
                     ..||...|||       .|...||..:|       .::||.::.:..|
Human   563 ---------ETAVETSTPKIKTGSSSLEGQFPNEGIA-------IDMELQSDPEEQLSENACISE 611

  Fly   597 ----DNSNEADIT--------TGTNSHDFVFSDTIDHAAYFQEHQSTINHNFFT--SSSSSNTAT 647
                ..|.|...|        |.:.|.:.....::: ..:..|..||.|.:.:.  :|:..|...
Human   612 TSFSSESPEGACTSLPSPGGETQSTSEESCTPASLE-TTFCSEVSSTENTDKYNQRNSTDENFHA 675

  Fly   648 TAANKLEEHSDKPEDSPLPIASSISGSTPASSITSTSCTSSSS--SSASMSSSCSSSNSGSTTTA 710
            :..:::...|..||.|...:.|::..::.||.:::...||.:|  |...::|..||.:|...|:.
Human   676 SLMSEISPISTSPEISEASLMSNLPLTSEASPVSNLPLTSETSPMSDLPLTSETSSVSSMLLTSE 740

  Fly   711 PTTSSSAGAP--TAPLTLA--------------AAAETTLANVQAMLSTVAK-----LQQQQQEL 754
            .|..||...|  |:|::.:              :.:|..|:..:...|..||     |..||:.|
Human   741 TTFVSSLPLPSETSPISNSSINERMAHQQRKSPSVSEEPLSPQKDESSATAKPLGENLTSQQKNL 805

  Fly   755 -----PV------------------------------------------ELNSNEMYQHVQHDW- 771
                 |:                                          ||.|.||.:...|..
Human   806 SNTPEPIIMSSSSIAPEAFPSEDLHNKTLSQQTCKSHVDTEKPYPASIPELASTEMIKVKNHSVL 870

  Fly   772 ----------------------NFGD----IKLSSSQ--SSGDQ------QRNLSHEAIDLMDVV 802
                                  |.|:    .||...|  ||.|:      .||.:|:.......:
Human   871 QRTEKKVLPSPLELSVFSEGTDNKGNELPSAKLQDKQYISSVDKAPFSEGSRNKTHKQGSTQSRL 935

  Fly   803 QDADVIDDIMHNDVCHDVLGDE----DEGDQEEDEDDEVVECMTEEQQLID---------EDSEA 854
            :.:            |.....|    .:|.:.|..|.|:.:..|.||....         ||.::
Human   936 ETS------------HTSKSSEPSKSPDGIRNESRDSEISKRKTAEQHSFGICKEKRARIEDDQS 988

  Fly   855 VREIVD-------------------KLQ------------------------------------- 863
            .|.|..                   |:|
Human   989 TRNISSSSPPEKEQPPREEPRVPPLKIQLSKIGPPFIIKSQPVSKPESRASTSTSVSGGRNTGAR 1053

  Fly   864 -------QHQQQQNQQQ-------------------------------------------HHQ-- 876
                   :.||.:.|::                                           .||
Human  1054 TLADIKARAQQARAQREAAAAAAVAAAASIVSGAMGSPGEGGKTRTLAHIKEQTKAKLFAKHQAR 1118

  Fly   877 ------------------------------------------------------QLHIQDVVQLA 887
                                                                  ..|:::...:.
Human  1119 AHLFQTSKETRLPPPLSSKEGPPNLEVSSTPETKMEGSTGVIIVNPNCRSPSNKSAHLRETTTVL 1183

  Fly   888 QHSFMPQAHSEFGNDIGQEMLCDAVPMS-AAEMEVSSTVITNSSNS---NDSSNNISLCSSTNSL 948
            |.|..|....|...|:......:.:|:| .:|..||||...|||..   |.:|..:|:||:..|.
Human  1184 QQSLNPSKLPETATDLSVHSSDENIPVSHLSEKIVSSTSSENSSVPMLFNKNSVPVSVCSTAISG 1248

  Fly   949 TINQMPH-------------------------------QASQQP------------------QQN 964
            .|.:.|.                               |.:..|                  :.:
Human  1249 AIKEHPFVSSVDKSSVLMSVDSANTTISACNISMLKTIQGTDTPCIAIIPKCIESTPISATTEGS 1313

  Fly   965 AQSNAQQQRQILVDSNG--------------QIIGNFL-----------------------LQQQ 992
            :.|::...:|:|:.|:.              ..|||.|                       :...
Human  1314 SISSSMDDKQLLISSSSASNLVSTQYTSVPTPSIGNNLPNLSTSSVLIPPMGINNRFPSEKIAIP 1378

  Fly   993 RQQQQQQLLQQFTLQAAAA-------------------------------------------QQQ 1014
            ..::|..:....|::||.:                                           ...
Human  1379 GSEEQATVSMGTTVRAALSCSDSVAVTDSLVAHPTVAMFTGNMLTINSYDSPPKLSAESLDKNSG 1443

  Fly  1015 QQQQQQHQQQQQQQQQATSSNSLGKTLP--VALRNGTQQFLSPNLIAQQHQQQQQQQLEQHQQQA 1077
            .:.:..:..:.||.....:..::.:::|  |.:.:.|....|.:|.......:....|:....:.
Human  1444 PRNRADNSGKPQQPPGGFAPAAINRSIPCKVIVDHSTTLTSSLSLTVSVESSEASLDLQGRPVRT 1508

  Fly  1078 TAQQKHQQIQQFALQQAQLHQRQLLAQAANNNL------LQQQQQQQQNVALPTTQAKFIAKPL- 1135
            .|     .:|..|..|..:..|.  ...||..:      :.....:|.:..||.|.......||
Human  1509 EA-----SVQPVACPQVSVISRP--EPVANEGIDHSSTFIAASAAKQDSKTLPATCTSLRELPLV 1566

  Fly  1136 ------------NIISMTR-PA---NASPTTAATTANTA-------------------------- 1158
                        |.....| ||   :.:.||.:...|.:
Human  1567 PDKLNEPTAPSHNFAEQARGPAPFKSEADTTCSNQYNPSNRICWNDDGMRSTGQPLVTHSGSSKQ 1631

  Fly  1159 ------SIPSA----YANVVAVTGAQQQ-------------------------------QSPPVP 1182
                  |.|.|    :||.:.|:....:                               :.||..
Human  1632 KEYLEQSCPKAIKTEHANYLNVSELHPRNLVTNVALPVKSELHEADKGFRMDTEDFPGPELPPPA 1696

  Fly  1183 APQQQTVQQQQ--LANHNSNMQQLPNVLT--MKTLPPSG----------VPTTIAQQRLQPKMPT 1233
            |....:|||.|  .|:.:|.|::..::.|  :|.:|.:|          ....:..|.||..:|.
Human  1697 AEGASSVQQTQNMKASTSSPMEEAISLATDALKRVPGAGSSGCRLSSVEANNPLVTQLLQGNLPL 1761

  Fly  1234 GK-------GRKATSNRLP-------PGAVNLERSYQICQAVIQNSPNREN---LKAQLRPPAAI 1281
            .|       |.|...||||       .|....||:.:|    ..:|||.:.   |...|.|....
Human  1762 EKVLPQPRLGAKLEINRLPLPLQTTSVGKTAPERNVEI----PPSSPNPDGKGYLAGTLAPLQMR 1822

  Fly  1282 LNQHQPTTTTA------------PAP--INPVTLNVSTVAATPMSNITTA---------TGSMAA 1323
            ..::.|....|            |..  :.|....|..|.::.:|.:..:         ..||..
Human  1823 KRENHPKKRVARTVGEHTQVKCEPGKLLVEPDVKGVPCVISSGISQLGHSQPFKQEWLNKHSMQN 1887

  Fly  1324 AVAAAPPQNVLKQEELLVSGAVGAGALPAGLPPNVMGVGRPGVYKVIGPRMSGF-------PRKK 1381
            .:..:|  .|.:|:.||.|         .....|:..|.:.|          ||       .|::
Human  1888 RIVHSP--EVKQQKRLLPS---------CSFQQNLFHVDKNG----------GFHTDAGTSHRQQ 1931

  Fly  1382 YVQ-----RKPSPTTLIRHVFSPGPGGATATAQQLQMLQQH-HQSTTSPVPVQ-------NPQQP 1433
            :.|     |.|.||..:....|..|.|..|.|....:.|:. .:.:.|..|.|       :|..|
Human  1932 FYQMPVAARGPIPTAALLQASSKTPVGCNAFAFNRHLEQKGLGEVSLSSAPHQLRLANMLSPNMP 1996

  Fly  1434 APE-----QLIHQNGNGQYVLVHRANVGAADNQAPRASSAPPMHQNQFVTVQNPLHSINGIPMGG 1493
            ..|     ...|...|  ..|||...........|.|...||...   ..:..||.:.. :|...
Human  1997 MKEGDEVGGTAHTMPN--KALVHPPPPPPPPPPPPLALPPPPPPP---PPLPPPLPNAE-VPSDQ 2055

  Fly  1494 RGRPASVDTT------AGSG---NVIAPPISATDAL-----------HHHHHEMQQQ-------- 1530
            :..|.:::||      ..:|   |:.:.|:|..:.|           .:..:||::|
Human  2056 KQPPVTMETTKRLSWPQSTGICSNIKSEPLSFEEGLSSSCELGMKQVSYDQNEMKEQLKAFALKS 2120

  Fly  1531 -----------------------QQHQQPQPLGNVGAAANIVRRNIAAGPNIAYIDGSNTNSSAV 1572
                                   |..||.|..||.              |.|.:  ||.:...|.
Human  2121 ADFSSYLLSEPQKPFTQLAAQKMQVQQQQQLCGNY--------------PTIHF--GSTSFKRAA 2169

  Fly  1573 ALME-------AGNNYIVTTNASPTAAPSPINQQPQSQPTGTQHQHPLLQLHQTGENTPPGNEAT 1630
            :.:|       :|:|                   |.:..:|...|.|:       :|....:.|.
Human  2170 SAIEKSIGILGSGSN-------------------PATGLSGQNAQMPV-------QNFADSSNAD 2208

  Fly  1631 ATANNCACSLNAMVICQQCGAFCHDDCIGAAKLCVACVI 1669
            .....|:|.|.||::|:.|||||||||||.:||||||::
Human  2209 ELELKCSCRLKAMIVCKGCGAFCHDDCIGPSKLCVACLV 2247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asx	NP_001260969.1	ASXH	196..333	CDD:290630	67/136 (49%)
Asx	NP_001260969.1	PHD_3	1603..1669	CDD:290633	28/65 (43%)
ASXL3	XP_005258413.1	HARE-HTH	11..82	CDD:282869
		ASXH	236..359	CDD:290630	68/141 (48%)
		PHD_3	2192..2247	CDD:290633	27/61 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148433
Domainoid	1	1.000	129	1.000	Domainoid score	I5241
eggNOG	1	0.900	-	-		E1_28Q0U
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3234
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40705
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13578
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4475
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.970