DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asx and asxl1

DIOPT Version :9

Sequence 1:	NP_001260969.1	Gene:	Asx / 36612	FlyBaseID:	FBgn0261823	Length:	1670	Species:	Drosophila melanogaster
Sequence 2:	XP_021325683.1	Gene:	asxl1 / 403066	ZFINID:	ZDB-GENE-091116-9	Length:	1670	Species:	Danio rerio

Alignment Length:	1863	Identity:	381/1863 - (20%)
Similarity:	632/1863 - (33%)	Gaps:	576/1863 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 KKPMAPSEEAAVSTAPAPPTRLICSRRIQQQQQVKAAAAAAAAAAAAAAAAAAAAQAQATSSYPS 158
            |.|.|  .|:...|..|..|..:   ...:|:...:...|||:....|:....::.|..::...:
Zfish    95 KSPSA--NESGDGTPTASTTSTV---EGAEQESCDSTETAAASGENDASVDETSSSASCSTEPQT 154

  Fly   159 AISPGSKAGTSQASTM---REVLASI----------------------PGFSVKPRRRSNKKLT- 197
            .:|..|::|..:...:   |.||..:                      ||.:::.|.....|.|
Zfish   155 RLSRSSQSGRQRKKAVMMPRVVLTPLKVNGEHVPSGAAGRRREGSRGGPGPTLRTRSELGWKRTQ 219

  Fly   198 -------------------TAAQIEQTKDG-KIDLETPDSILASTNLRALLNKQTFSLLPPLYQY 242
                               ..:.:::::.| ::|.|||.|||.:||:|||:|.:||:..|...|.
Zfish   220 HFKSIRGLRSGTEDENQGPPCSPMKRSRGGVEVDFETPGSILVNTNIRALINTRTFAAFPSHSQQ 284

  Fly   243 NLIQLLPSVDREASELEQPSSSASGGSPSEAIRLSASCLNNEFFARACLEWRERLSEGEFTPENQ 307
            .|:||||.|||:.             .|....|||:|.||||||..|...|:|||:|||||.|.|
Zfish   285 QLLQLLPEVDRQV-------------GPDGLARLSSSALNNEFFTHASQSWKERLAEGEFTHEMQ 336

  Fly   308 LKLKTEAEREKNKLDPWKLKHFEPFWGEKNSRGKDKD-KLESDCKNQKLSASIKSEPKPPATSQQ 371
            ::.:.|.|:|| |::.||.|.||.:.|:::...:::. ||.........|..:.|:....||.::
Zfish   337 VRFRQEMEKEK-KVEAWKEKFFEEYHGQRSGLTREEALKLTMSEAGDVASPVLDSDSATVATPKR 400

  Fly   372 KPLQQATCDN--ETELKFDLSTKCETTSAKTTVAVAVADKSSTFPPTGSQNNVLNEQQRRVLKRP 434
            :.:.:...:.  ....:.||..:...|..|||.|....::::....|                 |
Zfish   401 RSVGRRRREGRIRRRSRADLRRRARRTLCKTTTATVATEETTESTAT-----------------P 448

  Fly   435 SSSPSQRKQAPTTIAT---INLDDDLDELPSTSKDSKQPKMDEIVPNASGNVVAAPMVDVVDHSA 496
            ...||.....|.|.|.   :.|..|             |:::....|.|...|.:|:
Zfish   449 EEVPSVASPVPETTAVQGEVVLQTD-------------PELEAPEENLSTEAVPSPV-------- 492

  Fly   497 VEMKIKDEQQHQRQHQPL-------INSTCDKIEPSECSKEMIVAMKQVDSKEDVDSIASAAAMP 554
                            |:       .:||||:.|.|
Zfish   493 ----------------PVPTPPPASTSSTCDEPETS----------------------------- 512

  Fly   555 AIAAVTPHTPKPEALAPNPDVANQFVSYLQNVELAAETKAPLDNSNEADITTGTNSHDFVFSDTI 619
              ..:.|..|:|                     ..|.|.:|..:|:....::..:|.....||..
Zfish   513 --TRLLPEVPEP---------------------AVASTSSPSSSSSSTSSSSSPSSSPSSASDRQ 554

  Fly   620 DHAAYFQEHQSTINHNFFTSSSSSNTATTAANKLEE------------HSDKPEDSPLPIASSIS 672
            ..||....          :|||||:||..|.:.|::            .:...|.||   |:|.:
Zfish   555 TFAASSDS----------SSSSSSSTAAVATDPLDDGASVITTGTAGTGASSRESSP---AASPA 606

  Fly   673 GSTPASSI--------TSTSCTSSSSSSASMSSSCSSSNS----GSTTTAPTTSSS--------- 716
            .|:||..:        .|.:.||.....|.:....|..|:    .|....|||...
Zfish   607 TSSPAIQLKEQKRRPDESQAFTSFPEKRARLDERQSFRNTVDCVHSEKPQPTTEEPKVPPIRIQL 671

  Fly   717 --------AGAPTAPL-----------TLAAAAETTLANVQAMLSTVAKLQQQQQE--------- 753
                    .|.||..:           ..:.....|||:::|.    |:..:.|:|
Zfish   672 SRIKPPWVKGPPTYQICPRIVPPNEGSRRSGTGARTLADIKAR----AQQARAQREAAAAVAASG 732

  Fly   754 ---------------LPVELNSNEMYQH---VQHDWNFG------DIK----LSSSQSSGDQQRN 790
                           :|...:.....:|   |:.....|      |::    .:||.|||.|
Zfish   733 DGGGPGGSGPGGGTGIPDRSSGRRTREHPGPVEPGGGGGRRGGRVDLEEQESPASSHSSGAQ--- 794

  Fly   791 LSHEAIDLMDVVQDADVIDDIMHNDVCHD----------VL-----GDEDEGDQEEDED----DE 836
            |...::|..|..|.:..:.:...:.|..:          :|     ..:....|::.|:    :|
Zfish   795 LQLSSVDSADRPQTSTPLTEPSPSSVSSNPSLPSSESPKILALSPPATDSPASQDQVEEICGVEE 859

  Fly   837 VVEC---MTEEQQL---IDEDSEAVREIVDKLQQHQQQQNQQQHHQQLHI---------QDVVQL 886
            |..|   .|.||.|   :...||:     :....||..:.::........         .|.:.|
Zfish   860 VTACPSDKTSEQTLDTPVPTPSES-----ESFCSHQDGRGEEAESSDSRTNTPVCTSSSNDAISL 919

  Fly   887 AQHSFMPQAHSEFGN---DIGQEMLCDAVP----MSAAEMEVSST-VITNSSNSNDSSNNISLCS 943
            ...| :|.:...||.   |:.:.:...:.|    ..|.|:...:| ||.:.|:......  :|.:
Zfish   920 VPTS-IPDSLPRFGAQGVDVIRTLAASSQPWEGEKKAVELHPGTTGVIQHGSDLKLPKE--TLVT 981

  Fly   944 STNSLTINQMPHQASQ---QPQQNAQSNA------------------------------------ 969
            :.|....|:..|...:   :..:|..|:|
Zfish   982 ARNGWVENREEHSMREGMLEEHRNGGSDANGKYESGSLPCLPRCAGEEDTGAHSDSTETASDFEN 1046

  Fly   970 QQQRQILVDSNG-QIIGNFLLQQQRQQQQQQLLQQFT-LQAAAAQQQQQQQ---QQHQQQQQQQQ 1029
            :.|...:||.:| |:.|:.:..|..:...:.::|..: |.::.....|.||   |.|...|...|
Zfish  1047 ESQEDEMVDWHGTQMDGSGMQTQNTKSLNRPVIQTSSRLTSSIVNPPQHQQPVIQAHISNQNHTQ 1111

  Fly  1030 QATSSNSLGKTLPVALRNGTQQFLSPNL-IAQQHQQQ--QQQQLEQHQQQATAQQKHQQIQQFAL 1091
                     ..:.....||.     ||. :...|:|.  ....:...|.|..:.....|:|.: |
Zfish  1112 ---------TVIQACFPNGV-----PNQPVIHPHKQHAINTHAINHSQDQIASAPSQAQVQAY-L 1161

  Fly  1092 QQAQLHQRQLLAQAANNNLLQQQQQQQQNVALPTTQAKFIAKPLNIISMTRPANASPTTA-ATTA 1155
            .|.::.|.:.|....|.|.::....:..            .|||....:....:|.|... ....
Zfish  1162 TQTEMDQSRNLRLNDNGNGVKLYLSEDD------------TKPLGREDLVLKNSAGPPVGRRVQV 1214

  Fly  1156 NTASIPSAYANVVAVTGAQQQQSP---PVPAPQQQT-VQQQQLANHNSNMQQLP-NVLTMKTL-- 1213
            ::..:.:..||...||...|...|   .:|.|...: ::..:|...||:....| |..|.:.|
Zfish  1215 SSRPVSTVEANNPLVTQLLQGSLPLEKVLPQPHSASKLEINRLPGANSSNSLNPANHQTQRNLAP 1279

  Fly  1214 -----PPSGVPTTIAQQRLQPKMP-----TGKGRKATSNRLPPGAVNLERSYQICQAVIQNSPNR 1268
                 |.||.||.......|.|.|     .|.||...|:  |||:.. .|...:.:.....|.|.
Zfish  1280 RFRGPPESGGPTDTVSSDFQHKTPPARVSPGPGRNFGSS--PPGSAP-SRMACLFEEASPRSANS 1341

  Fly  1269 ENLKAQ---LRPPAAILNQHQPTTTTAPAPINPVTLNVSTVAATPMSNITTATGSMAAAVAAAP- 1329
            :....|   :.||.|:     |..|:.|       ||.:|..:..| |...|....:|.:...|
Zfish  1342 QFSSQQPGGVVPPGAV-----PVITSLP-------LNSTTRTSMDM-NSQNAPVYESAVIKEHPG 1393

  Fly  1330 ------------------PQNVLKQEELLVSGAVGAGALPAG--LPPNVMGVGRPGVYKVIGPRM 1374
                              |.||   .:.:......|.:.|.|  .|..|:    |.|      ::
Zfish  1394 PLSQRSETPERPSSFQQHPNNV---SQSVCRNTPDAPSPPHGDLCPSEVV----PTV------KI 1445

  Fly  1375 SGFPRKKYVQRKPSPTTLIRHVFSPGPGGATATAQQLQMLQQHHQSTTSPVPVQNPQQPAPEQLI 1439
            :..|.|.  |:..||...:::..|..|....|..:            .||.|:
Zfish  1446 NWRPNKP--QQPISPVATVKNEVSLRPSCQQALTK------------NSPAPI------------ 1484

  Fly  1440 HQNGNGQYVLVHRANV-------GAADNQAPRASSAPPMHQNQFVTVQNPLHSINGIPMGGRGRP 1497
              :||...|:..:..:       ||.:.......|...|.:.:  .|:||.             .
Zfish  1485 --SGNTSVVITKKEPLDGFHGGGGAMEGLLNMEMSLVRMAKKE--QVKNPY-------------T 1532

  Fly  1498 ASVDTTAGSGNVIAPPISATDALHHH-HHEMQQQQQHQQPQPLGNVGAAANIVRRNIAAGPNIAY 1561
            ...||:|..  |.:.|.|:..:|... :.::.:.||..     ||.|:::     :.:...|::.
Zfish  1533 RQADTSASP--VSSSPSSSASSLPFQLYGKLPKLQQSG-----GNGGSSS-----SFSYTANVSV 1585

  Fly  1562 IDGSNTNSSAVALMEAGNNYIVTTNASPTAAPSPINQQPQSQPTGTQHQHPLLQLHQTGENTPPG 1626
            :|||                    ..:.|.|.|.:..:|:........|...|.:....::.
Zfish  1586 VDGS--------------------GFTRTLADSVLQLRPRVSVGSGGGQSATLGIQAFTDSA--- 1627

  Fly  1627 NEATATANNCACSLNAMVICQQCGAFCHDDCIGAAKLCVACVI 1669
              |...|..|:|.|.||::||.|||||||||||.:||||:|::
Zfish  1628 --AEEVALKCSCRLKAMIMCQGCGAFCHDDCIGPSKLCVSCLV 1668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asx	NP_001260969.1	ASXH	196..333	CDD:290630	60/157 (38%)
Asx	NP_001260969.1	PHD_3	1603..1669	CDD:290633	27/65 (42%)
asxl1	XP_021325683.1	HARE-HTH	11..86	CDD:309974
		ASXH	241..361	CDD:316441	59/133 (44%)
		Atrophin-1	<1200..1460	CDD:331285	65/290 (22%)
		PHD_3	<1626..1668	CDD:316444	25/46 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582309
Domainoid	1	1.000	125	1.000	Domainoid score	I5419
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3326
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26369
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13578
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4475
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	8.070