DRSC/TRiP Functional Genomics Resources

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Protein Alignment Asx and Asxl1

DIOPT Version :10

Sequence 1:NP_001260969.1 Gene:Asx / 36612 FlyBaseID:FBgn0261823 Length:1670 Species:Drosophila melanogaster
Sequence 2:NP_001035028.1 Gene:Asxl1 / 228790 MGIID:2684063 Length:1514 Species:Mus musculus


Alignment Length:1773 Identity:337/1773 - (19%)
Similarity:573/1773 - (32%) Gaps:557/1773 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 DDEKDPLALEQLEVSPSTKHTHSLRRH---------LPRIIVKPIPPEKKPMAPSEEAAVSTAPA 110
            :.:..||:      :|...|..|.:.:         |||:::.|:             .|:.|..
Mouse   139 ESQSRPLS------NPRDSHRASSQANKQKKRTGVMLPRVVLTPL-------------KVNGAHV 184

  Fly   111 PPTRLICSRRIQQQQQVKAAAAAAAAAAAAAAAAAAAAQAQATSSYPSAISPGSKA-GTS----Q 170
            .|                             |:..:...|...|..||:.|.||.| |.|    |
Mouse   185 EP-----------------------------ASGFSGRHADGESGSPSSSSSGSLALGNSAIRGQ 220

  Fly   171 ASTMREVLASIPGFSVKPRRRSNKKLTTAAQIEQTKDGKIDLETPDSILASTNLRALLNKQTFSL 235
            |...|:....:.||. ||         ...|:::.:..::|.|||.|||.:||||||:|.:||..
Mouse   221 AEVTRDPAPLLRGFR-KP---------ATGQMKRNRGEEVDFETPGSILVNTNLRALINSRTFHA 275

  Fly   236 LPPLYQYNLIQLLPSVDREASELEQPSSSASGGSPSEAIRLSASCLNNEFFARACLEWRERLSEG 300
            ||..:|..|:.|||.|||:.             .....:|||.|.||||||..|...|||||::|
Mouse   276 LPLHFQQQLLLLLPEVDRQV-------------GTDGLLRLSGSALNNEFFTHAAQSWRERLADG 327

  Fly   301 EFTPENQLKLKTEAEREKNKLDPWKLKHFEPFWGEKNSRGKDKDKLESDCKNQKLSASIKSEPKP 365
            |||.|.|::|:.|.|:|| |::.||.|.||.::|:|....|::                      
Mouse   328 EFTHEMQVRLRQEMEKEK-KVEQWKEKFFEDYYGQKLGLTKEE---------------------- 369

  Fly   366 PATSQQKPLQQATCDNETELKFDLSTKCETTSAKTTVAVAVADKSSTFPPTGSQNNVLNEQQRRV 430
              :.|||.:|:     |.::|..|....|:.            :....|.|..::....::.|..
Mouse   370 --SLQQKEVQE-----EAKVKSGLCVSGESV------------RPQRGPNTRQRDGHFKKRSRPD 415

  Fly   431 LKRPSSSPSQRKQAPTTIATINLDDDLDELPSTSKDSKQPKMDEIVPNASGNVVAAPMVDVVDHS 495
            |:..|.....:||.|.......   |....|..|. ||..|.|....|::..             
Mouse   416 LRTRSRRNIYKKQEPEQAGVAK---DASAAPDVSL-SKDTKTDLAGVNSTPG------------- 463

  Fly   496 AVEMKIKDEQQHQRQHQPLINSTCDKIEPSECSKEMIVAMKQVDSKEDVDSIASAAAMPAIAAVT 560
                             |.::|.....|..:|..|.:.:..|.:.    |::|.|:|.|......
Mouse   464 -----------------PDVSSATSGQEGPKCPSEPVASQIQAER----DNLACASASPDRIPTL 507

  Fly   561 PHTPKPEALAPNPDVANQFVSYLQNVELAAETKAPLDNSNEADITTGTNSHDFVFSDTIDHAAYF 625
            |.           |..:|            |||.....|.|.:.                 :|.|
Mouse   508 PQ-----------DTVDQ------------ETKDQKRKSFEQEA-----------------SASF 532

  Fly   626 QEHQSTINHNFFTSSSSSNTATTAANKLEEHSDKPE---DSP----------------------- 664
            .|.:..:...    .|..||..:.      |::||:   :.|                       
Mouse   533 PEKKPRLEDR----QSFRNTIESV------HTEKPQPTKEEPKVPPIRIQLSRIKPPWVAKGRPT 587

  Fly   665 -------LPIA-SSISGSTPASSI---------------------TSTSCTSSSSSSASMSSSCS 700
                   :||. ||..|.|.|.::                     |:|:............|...
Mouse   588 YQICPRIVPITESSCRGWTGARTLADIKARALQARGARGYHCNRETATTAIGGGGGPGGGGSGAI 652

  Fly   701 SSNSGSTTTAPTTSSSAGAPT---APLTLAAAAETTLANVQAMLSTVAKLQQQQQELPVELNSNE 762
            ....|..:::...|.:.|.|.   ||.|...:|              :.||:.|...|..||.  
Mouse   653 DEGGGRDSSSGDGSEACGHPEPRGAPSTSGESA--------------SDLQRTQLLPPCPLNG-- 701

  Fly   763 MYQHVQHDWNFGDIKLSSSQSSGDQQRNLSHEAIDLMDVVQD--ADVIDDIMHNDVCHDVLGDED 825
              :|.       ..:.:..::..:...:|..|...|:..|..  ...::|.....:.       .
Mouse   702 --EHT-------PAEAAMPRARREDSASLRKEESCLLKRVPGVLTSGLEDASQPPIA-------P 750

  Fly   826 EGDQ------EEDEDDEVVECMTEEQQLIDEDSEAVREIVDKLQQHQQQQNQQQHHQQLHIQDVV 884
            .|||      .......|.|.:||:.:|:         :.|:.:....:::|.            
Mouse   751 TGDQPCQALPPLSSQTPVAEMLTEQPKLL---------LDDRTECESSREDQG------------ 794

  Fly   885 QLAQHSFMPQAHSEFGN------DI---GQEMLCDAV--PMSAAEMEVSSTVITNSSNSNDSSNN 938
                    |...||..:      |:   |.:...|.:  |:|.....:|...:.|........:.
Mouse   795 --------PTIPSESSSGRFPLGDLLGGGSDQAFDNMKEPVSMTPTFISELSLANYLQDRPDDDG 851

  Fly   939 ISLCSSTNSLTINQMPHQASQQPQQNAQSNAQQQRQILVDSNGQIIGNFLLQQQR-----QQQQQ 998
            :.|  ....|.|.:   .:.|:....|.::......:.:.||.::|.....:.:.     :.|.:
Mouse   852 LGL--GATGLLIRE---SSRQEALTEAFASGSPTSWVPILSNYEVIKTSDPESRENIPCPEPQDE 911

  Fly   999 QLLQQFTLQAAAAQQQQQQQQ--QHQQQQQQQQQATSSNSLGKTLPVALRNGTQQFLSPNLIAQQ 1061
            :..::.....||.:...|.:.  .|.........:|.|:|....|.....||..:..||:..:..
Mouse   912 KEWERAVPLIAATESVPQPESCISHWTPPPAAVGSTGSDSEQVDLERLEMNGISEAPSPHSESTD 976

  Fly  1062 HQQQQQQQLEQHQQQATAQQKHQQIQQFALQQAQLHQRQLLAQAANNNLLQQQQQQQQNVALPTT 1126
            .....:..|.:...:..|.:                     ......:|...::|...    |:.
Mouse   977 TASDSEGHLSEDSSEVDASE---------------------VTVVKGSLGGDEKQDWD----PSA 1016

  Fly  1127 QAKFIAKPLNIISMTRPANASPTTAATTANTASIPSAYANVVAVTGAQQQQSPPVPAPQQQTVQQ 1191
            ....:...|::::.|....||   .:..:...|:|....:.:.::..:.|.....|.....:|  
Mouse  1017 SLSKVNNDLSVLTRTGGVAAS---QSWVSRVCSVPHKIPDSLLLSSTECQPRSVCPLRPGSSV-- 1076

  Fly  1192 QQLANHNSNMQQLPNVLTMKTLPPSGVPTTIAQQRLQPKMPTG-KGRKATSNRLPPGAVNLERSY 1255
                       ::.|.|.|..| ...:|       |:..:|.| :..:..|::||....:.:|  
Mouse  1077 -----------EVTNPLVMHLL-HGNLP-------LEKVLPPGHRSSRLESSQLPLREQSQDR-- 1120

  Fly  1256 QICQAVIQNSPNRENLKAQLRPPAA------ILNQH--------QPTTTTAPAPINPVTLNVSTV 1306
                ..:|.:.....|.|::.|.:|      ||.|.        :...:.|||....:...|:::
Mouse  1121 ----GTLQGTGENNRLAARINPGSAQTLKESILAQSYGASAGLVRAMASKAPAMSQKIAKMVTSL 1181

  Fly  1307 -AATPMSNITTATGSMAAAVAAAPPQNVLKQEELLVSGAVGAGALPAGLPPNVMG---------V 1361
             :..|.:.:|.::|::....:.....:.|.:|: ....::..|:.|...|...:|         .
Mouse  1182 DSQHPETELTPSSGNLEEIDSKEHLSSFLCEEQ-KEGHSLSQGSDPGAAPGQCLGDHTTSKVPCF 1245

  Fly  1362 GRPGVYKVIGPRMS-----------GFPRKKYVQRKPSPTTLIRHVFSPGPGGATATAQQLQMLQ 1415
            ....|....|...:           |..:|.:                 |||....|      ||
Mouse  1246 SSTNVSLSFGSEQTDGTLSDQNNAGGHEKKLF-----------------GPGNTVTT------LQ 1287

  Fly  1416 QHHQSTTSPVPVQNPQQPA-PEQLIHQNGNGQYVLVHRANVGAADNQAPRASSAPPMHQNQFVTV 1479
            .......:|:|.:.|  |. |.:.|..:.|.       .:.|....:..|....||:..:...|.
Mouse  1288 CPRSEEQTPLPAEVP--PVFPSRKIEPSKNS-------VSGGVQTTRENRMPKPPPVSADSIKTE 1343

  Fly  1480 Q----NPLHS---------INGIPMGG--RGRPASVD-------TTAGSGNVIAPPISATDALHH 1522
            |    :|:.:         .:.:.:.|  :|.|..||       ...|.|               
Mouse  1344 QTFLRDPIKADAENRKAAGYSSLELVGHLQGMPFVVDLPFWKLPREPGKG--------------- 1393

  Fly  1523 HHHEMQQQQQHQQPQPLGNVGAAANIVRRNIAAGPNIAYIDGSNTNSSAVALMEAGNNYIVTTNA 1587
                      ..||....::.:..||  :....|           ..|.:.|.....||..::..
Mouse  1394 ----------FSQPLEPSSIPSQLNI--KQALYG-----------KLSKLQLSPTSFNYSSSSAT 1435

  Fly  1588 SPTAAPSPINQQPQSQPTGTQHQHPL-LQLHQTGENTPPGNEATATANNCACSLNAMVICQQCGA 1651
            .|......:.|.......||.|...| ||:.      ...:...:.:..|||||.||::||.|||
Mouse  1436 FPKGLAGGVVQLSHKASFGTGHTASLSLQMF------ADSSAVESISLQCACSLKAMIMCQGCGA 1494

  Fly  1652 FCHDDCIGAAKLCVACVI 1669
            ||||||||.:||||.|::
Mouse  1495 FCHDDCIGPSKLCVLCLV 1512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AsxNP_001260969.1 ASXH 196..335 CDD:464041 60/138 (43%)
PHD_3 1603..1669 CDD:316444 31/66 (47%)
Asxl1NP_001035028.1 HARE-HTH 11..83 CDD:461541
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..170 5/36 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..249 20/104 (19%)
ASXH 236..361 CDD:464041 62/147 (42%)
Interaction with nucleosomal DNA forming a DNA clamp with BAP1. /evidence=ECO:0000250|UniProtKB:Q8IXJ9 243..246 0/2 (0%)
LXXLL motif 1 284..288 1/3 (33%)
Interaction with NCOA1. /evidence=ECO:0000250|UniProtKB:Q8IXJ9 300..655 99/484 (20%)
NEF motif. /evidence=ECO:0000250|UniProtKB:Q8IXJ9 310..315 4/4 (100%)
Interaction with nucleosomal DNA. /evidence=ECO:0000250|UniProtKB:Q8IXJ9 336..346 5/10 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 378..543 42/263 (16%)
Nuclear localization signal. /evidence=ECO:0000255|PROSITE-ProRule:PRU00768 408..415 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 635..823 38/248 (15%)
LXXLL motif 2 808..812 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 895..914 1/18 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 926..952 4/25 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..995 3/30 (10%)
Required for interaction with RARA. /evidence=ECO:0000250 1082..1087 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1095..1131 7/41 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1213..1234 4/21 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1256..1338 19/113 (17%)
PHD_3 <1479..1512 CDD:316444 25/32 (78%)
Blue background indicates that the domain is not in the aligned region.

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