DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Asx and Asxl3

DIOPT Version :9

Sequence 1:NP_001260969.1 Gene:Asx / 36612 FlyBaseID:FBgn0261823 Length:1670 Species:Drosophila melanogaster
Sequence 2:XP_006525803.1 Gene:Asxl3 / 211961 MGIID:2685175 Length:2261 Species:Mus musculus


Alignment Length:2341 Identity:457/2341 - (19%)
Similarity:731/2341 - (31%) Gaps:897/2341 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 VNLVDDDEKDPLALEQLEVSPSTKHTHSLRRHLPRIIVKPIPPEKKPMAPSEEAAVSTAPAPPTR 114
            ::||.|.:.|  ..|..|.|.:.:..        |:..|.:..|   ::.:.:.:: |..|..::
Mouse    95 LDLVVDPDLD--GAEMAEASANGEEN--------RVCTKQVTDE---VSSTRDCSL-TNTAVQSK 145

  Fly   115 LICS----------RRIQQQQQVKAAAAAAAAAAAAAAAAAAAAQAQATSSYPSAISPGSKAGTS 169
            |:.|          :.::|||:.:...:.................:...|..||...  ||.|.:
Mouse   146 LVSSFQQHTKKALKQALRQQQKRRNGVSMMVNKTVPRVVLTPLKVSDEQSDSPSGSE--SKNGEA 208

  Fly   170 QAS--TMREVLASIPGFSVKPRRRSNKKLTTAAQIEQTKDGKIDLETPDSILASTNLRALLNKQT 232
            .:|  .|:....|..|.......:..|| :....::.||...||:|||.|||.:||||||:||.|
Mouse   209 DSSDKEMKHGQKSPTGKQTSQHLKRLKK-SGLGHLKWTKAEDIDIETPGSILVNTNLRALINKHT 272

  Fly   233 FSLLPPLYQYNLIQLLPSVDREASELEQPSSSASGGSPSEAIRLSASCLNNEFFARACLEWRERL 297
            |:..|..:|..|:.|||.|||:.            ||.. .:|||.|.|||||||.|...|::||
Mouse   273 FASFPQHFQQYLLLLLPEVDRQM------------GSDG-ILRLSTSALNNEFFAYAAQGWKQRL 324

  Fly   298 SEGEFTPENQLKLKTEAEREKNKLDPWKLKHFEPFWGEKNSRGKDKD-KLESDCKNQKLSASI-- 359
            :|||||||.||:::.|.|:|| |.:|||.|.||.|:||::...:::. ||.|...::....|.  
Mouse   325 AEGEFTPEMQLRIRQEIEKEK-KTEPWKEKFFERFYGERSGMSREESIKLTSGPNHEGAEGSSSH 388

  Fly   360 --KSEPKPPATSQQKPLQQATCDNETELKFDLSTKCETTSAKTTVAVAVADKSSTFPPTGSQNNV 422
              ...|.|.|.:..:..|.....:...|:.|.   |.|......|.|               .:|
Mouse   389 GDSGIPGPSAQNALEEQQPKILKSSASLEPDF---CTTVCPMLEVPV---------------KDV 435

  Fly   423 LNEQQRRVLKRPSSSPSQRKQAPTTIATIN--LDDDLDELPSTSKDSKQPKMDEIVPNASGNVVA 485
            :.|.:...:..|..|..|.:.|.....:|.  .|:.|..:|:.|::|:.|......|.     ||
Mouse   436 MTESETEDIFIPEESVIQEEVAEEVETSIYECQDEHLKTIPAFSEESESPATPCEEPQ-----VA 495

  Fly   486 AP---------MVDVVDHSA--VEMKIKDEQQHQRQHQPLI---NSTCDKIEPSECSKEMIVAMK 536
            ||         |.|:: |:.  :|:||.::.:..::...::   ...||.:.|...|...|:.::
Mouse   496 APEDSLESCVVMNDIL-HTLPHIEVKIVEKLECPQEEMSVVIDQLEICDSLLPCPSSVTHILDVE 559

  Fly   537 QVDSKEDVDSIASA---------AAMP----------------------AIAAVTPHTPKPE--- 567
            |.:.:..:::.|.|         :.:|                      .|:..:..:..||   
Mouse   560 QKEQETTIETSAMALREGPSSLESQLPNEGIAVDMELQSDPEEQLSENACISETSFSSESPEGAC 624

  Fly   568 ALAPNPDVANQFVSYLQNVELAAET--------KAPLDNSNEADITTGTNSHDFVFSDTIDHAAY 624
            |..|:|....|..|.......:.||        ....|..|:.: .||.:.|..:.|:....|..
Mouse   625 ASLPSPGGETQSTSEESCTPASLETTFCSEVSSTENTDKYNQRN-PTGESLHASLVSEVSPLATS 688

  Fly   625 FQEHQSTINHNF-FTSSSS--SNTATTA----ANKLEEHSDKPEDSPLPIASSISGSTP-ASSI- 680
            .:..::::..|. .||.:|  ||...|:    .:.|...|:...:|.:|:.|    .|| .||: 
Mouse   689 PEISEASLMSNLPLTSEASPVSNLPLTSEASPMSDLPPTSETSSESSMPLTS----ETPFVSSLP 749

  Fly   681 --TSTSCTSSSSSSASMSSSCSSSNSG------------------------------STTTAPTT 713
              ..||..|:||.:..|......|.||                              ||...|..
Mouse   750 IPAETSPISNSSVNERMVHQQRKSPSGSEEANSPQKEEPSIPTKPLGESLVSHPKPLSTIPEPIN 814

  Fly   714 SSSAGAP---------------------------------------------------------T 721
            .|||..|                                                         :
Mouse   815 MSSAMVPEALPPEGLHSQTLSQEPCNAHVEMEKLYASSIPELPSSEMTKVKNHSVLQRPEKKGLS 879

  Fly   722 APLTLAAAAETTLANVQAMLSTVAKLQQQQQELPV------ELNSNEMYQH-------------- 766
            |||.:...:|.|  ..:.:....||||.:|....|      |.:.|::::.              
Mouse   880 APLEVPVFSEET--ETKGIELPPAKLQDKQYAPSVDKATFLEGSRNKIHKQSSTLNRLETSHTSK 942

  Fly   767 -------------------------VQHDWNFGDIK----------------------------- 777
                                     |:|  :||..|                             
Mouse   943 VSEPSKSPDGIRNDNRESEISKRKTVEH--SFGICKEKRARIEDDQSARSLASSSPPEKEQPPRE 1005

  Fly   778 ---------------------------------LSSSQSSG--------------DQQRNLSHEA 795
                                             .|:|.|||              .||.....||
Mouse  1006 EPRVPPLKIQLSKIGPPFIIKSQPVSKAESRASTSTSVSSGRNTGARTLADIKARAQQARAQREA 1070

  Fly   796 IDLMDVVQDADVIDDIMHNDVCHDVLGDEDEGDQ--------------------------EEDED 834
            .....|...|.::...|         |...||.:                          :..::
Mouse  1071 AAAAAVAAAASIVSGAM---------GSPGEGGKARTLAHIKEQTKAKLFAKHQSRAHLFQTSKE 1126

  Fly   835 DEVVECMTEEQQLIDEDSEA---------------------------VREIVDKLQQ-------- 864
            ..:....|:|..|..|.|..                           :|||...|||        
Mouse  1127 TRLPSVSTKEDSLNMEASPTPETKMEGSTGVIIINPNCRSPSSKPTHIREITTVLQQPLNPPQIP 1191

  Fly   865 --------HQQQQNQQQHHQQLHIQDVVQLAQHSFMPQAHSEFGNDIGQEMLCDAVPMSAAEMEV 921
                    |....|....|....|..... :::|.:|..|:        :...:.:|||.....:
Mouse  1192 ETATDLSVHSSDDNIPVSHLTEKIVSSTS-SENSSVPILHN--------KSPINPIPMSVCSTAM 1247

  Fly   922 S--------------STVI--TNSSNSNDSSNNISL----------CSSTNSLTINQMPHQASQQ 960
            |              |:|:  .:|:||..|:.|||:          |.:.....||:.|..|:  
Mouse  1248 SGAIKEHPFVSPVDKSSVLMSVDSANSTISACNISMLKSIQGSDAPCIALVPKCINRTPIPAA-- 1310

  Fly   961 PQQNAQSNAQQQRQILVDSN--GQIIG----------------NFLLQQQRQQQQQQLLQQFTLQ 1007
            |:...|||:...:.:||.|:  ..:|.                |.|...........:..:|..:
Mouse  1311 PEGTGQSNSMDGKALLVPSSKAANVISNQYTSVPAPTIASNLPNHLCTSSVLIPPTGINNRFVSE 1375

  Fly  1008 AAAAQQQQQQQQQHQQQQQQQQQATSSNSLGKTLPVALRNGTQQFLSPNLIAQQHQQQQQQQLEQ 1072
            ..|....::|               ::.|:|.|:..||..|....::.:|:.:            
Mouse  1376 KIAMPGSEEQ---------------AAVSIGATMRTALSCGDSVAVTDSLVPR------------ 1413

  Fly  1073 HQQQATAQQKHQQIQQFALQQAQLHQRQLLAQAANNNL-----------LQQQQQQQQNVALPTT 1126
                       ..|..||......:......:.:..||           ..::.||.....:|.|
Mouse  1414 -----------SPIAMFAGNMLTANSYNCPPKLSGENLDNNSGPLNRTDNSEKPQQPAGGFVPAT 1467

  Fly  1127 QAKFIAKPLNII---SMTRPANASPTTAATTANTASIPSAYANVVAVTGAQQQQSPPVPAPQQQT 1188
            ..:.|  |..:|   |.|..:|.| .|.:..:..:|:.|...:|......|     ||..||...
Mouse  1468 INRSI--PCKVIVDHSTTLTSNLS-LTVSIESGDSSLDSQTRSVRTDVSIQ-----PVACPQVSV 1524

  Fly  1189 VQQQQLA-----NHNS--------------------NMQQLPNVLTMK----TLPPSGVPTTIAQ 1224
            :.:.:.|     :|.|                    ::::||..|..|    |:|..|    .|:
Mouse  1525 ISRPEQATSEGLDHGSVFIAAPTAKQDCKTLQATCTSLRELPLTLPDKLNEVTVPTHG----FAE 1585

  Fly  1225 QRLQPKMPTGKGRKATSNRLPPGAVNLERSYQICQA----------VIQNS--------PNRENL 1271
            |.........:...|.||:..||       .:||.:          |:.:|        |.:..|
Mouse  1586 QARNSSTFKKETDTACSNQYNPG-------NRICWSEDPMRNTAPPVVSHSSSSKQKEHPEQTGL 1643

  Fly  1272 KA------------QLRPPAAILN--------QH------------------------------- 1285
            ||            .|.|...|.|        .|                               
Mouse  1644 KAVKTEHVSYAHVSDLHPRNLITNVSLPVKPEPHEVDKGFRMDTEDFPGPERPPPVTEVTSSASV 1708

  Fly  1286 QPTTTTAPAPINPVTLNVSTVAATPMSNITTATGSMA--AAVAAAPP------QNVLKQEELLVS 1342
            |||.|..|:..:||...:| :|...:..|.:|:.|..  ::|.|..|      |..|..|::|..
Mouse  1709 QPTQTMKPSTTSPVEEAIS-LAPDTLKRIPSASSSSCRLSSVEANNPLVTQLLQGNLPLEKVLPQ 1772

  Fly  1343 GAVGA----GALPAGLPPNVMGVGRPGVYK--------------------VIGP----RMSGFPR 1379
            ..:||    ..||  ||.....||:.|:.:                    .:.|    :....|:
Mouse  1773 PRLGAKLEINRLP--LPLQTTSVGKTGLERNMVEMPSSSPNPDGKGYLAGTLAPVQMRKRENHPK 1835

  Fly  1380 KK-------YVQRKPSPTTLIRH--------VFSPGPGGATATAQQLQMLQQHHQSTTSPVPVQN 1429
            |:       :.|.|..|..::..        |.||       :..||...|...|...:...:.|
Mouse  1836 KRAARTVGDHAQVKCEPGKMVMEPDVKAVPCVISP-------SMSQLGHNQPFKQERLNKPSMAN 1893

  Fly  1430 PQQPAPE---------------QLIHQNGNGQYVLVHRANVGAADN----QAPRASSAP------ 1469
            ...|:||               .|.|.|.|..:    .|:.|.:..    |.|.|:..|      
Mouse  1894 RIMPSPEVKQQKRLLPACSFQPSLFHVNKNEGF----HADTGTSHRQQFYQMPMAARGPLPTPAL 1954

  Fly  1470 -------PMHQNQFV----TVQNPLHSIN------------------------------------ 1487
                   |:..|.|.    ..|..|..:|                                    
Mouse  1955 LQNSPKTPVGCNAFAFNRHLEQKALGDVNLPTAPHQLRLANMLSPNMPIKEGEDGGGTTHTMPSK 2019

  Fly  1488 ----------------------------------------GIPMGGRGRPASVDTT------AGS 1506
                                                    .:|...:..|.:::||      ..:
Mouse  2020 AVVHAPLPPPPPPPPPPPPPLALPPPPPPPPPLPPPLPTVEVPSDQKQPPVNMETTKRLSWPQST 2084

  Fly  1507 G---NVIAPPISATDALHHHHHEMQQQQQHQQPQPLGNVGAAANIVRRNIAAGPNIAYIDGSNTN 1568
            |   |:.:.|:|..::|........:|..:.|           |.|:..:.|      ....|.:
Mouse  2085 GICSNIKSEPLSFEESLSSSCELGMKQVPYDQ-----------NEVKEQLKA------FALKNAD 2132

  Fly  1569 SSAVALMEAGNNYIVTTNASPTAAPSPINQQP--QSQPT---GTQH------------------Q 1610
            .|:..|.|....:   |..:....|.| .|||  .|.||   |:.:                  .
Mouse  2133 FSSYLLSEPQKPF---TQLAAQKLPVP-QQQPLCGSYPTIHFGSTNFKRAASAIEKSIGILGSGS 2193

  Fly  1611 HPLLQLHQTGENTPPGNEATATANN-------CACSLNAMVICQQCGAFCHDDCIGAAKLCVACV 1668
            :|......||:||....:..|..:|       |:|.|.||::|:.|||||||||||.:||||||:
Mouse  2194 NPATSTGLTGQNTQMPVQNFADNSNADELELKCSCRLKAMIVCKGCGAFCHDDCIGPSKLCVACL 2258

  Fly  1669 I 1669
            :
Mouse  2259 V 2259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AsxNP_001260969.1 ASXH 196..333 CDD:290630 66/136 (49%)
PHD_3 1603..1669 CDD:290633 33/93 (35%)
Asxl3XP_006525803.1 HARE-HTH 11..82 CDD:368272
ASXH 236..359 CDD:372815 67/137 (49%)
PHD_3 2204..2259 CDD:316444 27/54 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838548
Domainoid 1 1.000 125 1.000 Domainoid score I5439
eggNOG 1 0.900 - - E1_28Q0U
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 222 1.000 Inparanoid score I3522
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42779
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13578
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4475
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
88.010

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