Protein Alignment Asx and Asxl3

DIOPT Version :10

• Sequence 1: NP_001260969.1
• Gene: Asx / 36612
• FlyBaseID: FBgn0261823
• Length: 1670
• Species: Drosophila melanogaster
• Sequence 2: XP_006525803.1
• Gene: Asxl3 / 211961
• MGIID: 2685175
• Length: 2261
• Species: Mus musculus
• Alignment Length: 2341
• Identity: 457/2341 - (19%)
• Similarity: 731/2341 - (31%)
• Gaps: 897/2341 - (38%)

  Fly    50 VNLVDDDEKDPLALEQLEVSPSTKHTHSLRRHLPRIIVKPIPPEKKPMAPSEEAAVSTAPAPPTR 114
            ::||.|.:.|  ..|..|.|.:.:..        |:..|.:..|   ::.:.:.:: |..|..::
Mouse    95 LDLVVDPDLD--GAEMAEASANGEEN--------RVCTKQVTDE---VSSTRDCSL-TNTAVQSK 145

  Fly   115 LICS----------RRIQQQQQVKAAAAAAAAAAAAAAAAAAAAQAQATSSYPSAISPGSKAGTS 169
            |:.|          :.::|||:.:...:.................:...|..||...  ||.|.:
Mouse   146 LVSSFQQHTKKALKQALRQQQKRRNGVSMMVNKTVPRVVLTPLKVSDEQSDSPSGSE--SKNGEA 208

  Fly   170 QAS--TMREVLASIPGFSVKPRRRSNKKLTTAAQIEQTKDGKIDLETPDSILASTNLRALLNKQT 232
            .:|  .|:....|..|.......:..|| :....::.||...||:|||.|||.:||||||:||.|
Mouse   209 DSSDKEMKHGQKSPTGKQTSQHLKRLKK-SGLGHLKWTKAEDIDIETPGSILVNTNLRALINKHT 272

  Fly   233 FSLLPPLYQYNLIQLLPSVDREASELEQPSSSASGGSPSEAIRLSASCLNNEFFARACLEWRERL 297
            |:..|..:|..|:.|||.|||:.            ||.. .:|||.|.|||||||.|...|::||
Mouse   273 FASFPQHFQQYLLLLLPEVDRQM------------GSDG-ILRLSTSALNNEFFAYAAQGWKQRL 324

  Fly   298 SEGEFTPENQLKLKTEAEREKNKLDPWKLKHFEPFWGEKNSRGKDKD-KLESDCKNQKLSASI-- 359
            :|||||||.||:::.|.|:|| |.:|||.|.||.|:||::...:::. ||.|...::....|.
Mouse   325 AEGEFTPEMQLRIRQEIEKEK-KTEPWKEKFFERFYGERSGMSREESIKLTSGPNHEGAEGSSSH 388

  Fly   360 --KSEPKPPATSQQKPLQQATCDNETELKFDLSTKCETTSAKTTVAVAVADKSSTFPPTGSQNNV 422
              ...|.|.|.:..:..|.....:...|:.|.   |.|......|.|               .:|
Mouse   389 GDSGIPGPSAQNALEEQQPKILKSSASLEPDF---CTTVCPMLEVPV---------------KDV 435

  Fly   423 LNEQQRRVLKRPSSSPSQRKQAPTTIATIN--LDDDLDELPSTSKDSKQPKMDEIVPNASGNVVA 485
            :.|.:...:..|..|..|.:.|.....:|.  .|:.|..:|:.|::|:.|......|.     ||
Mouse   436 MTESETEDIFIPEESVIQEEVAEEVETSIYECQDEHLKTIPAFSEESESPATPCEEPQ-----VA 495

  Fly   486 AP---------MVDVVDHSA--VEMKIKDEQQHQRQHQPLI---NSTCDKIEPSECSKEMIVAMK 536
            ||         |.|:: |:.  :|:||.::.:..::...::   ...||.:.|...|...|:.::
Mouse   496 APEDSLESCVVMNDIL-HTLPHIEVKIVEKLECPQEEMSVVIDQLEICDSLLPCPSSVTHILDVE 559

  Fly   537 QVDSKEDVDSIASA---------AAMP----------------------AIAAVTPHTPKPE--- 567
            |.:.:..:::.|.|         :.:|                      .|:..:..:..||
Mouse   560 QKEQETTIETSAMALREGPSSLESQLPNEGIAVDMELQSDPEEQLSENACISETSFSSESPEGAC 624

  Fly   568 ALAPNPDVANQFVSYLQNVELAAET--------KAPLDNSNEADITTGTNSHDFVFSDTIDHAAY 624
            |..|:|....|..|.......:.||        ....|..|:.: .||.:.|..:.|:....|..
Mouse   625 ASLPSPGGETQSTSEESCTPASLETTFCSEVSSTENTDKYNQRN-PTGESLHASLVSEVSPLATS 688

  Fly   625 FQEHQSTINHNF-FTSSSS--SNTATTA----ANKLEEHSDKPEDSPLPIASSISGSTP-ASSI- 680
            .:..::::..|. .||.:|  ||...|:    .:.|...|:...:|.:|:.|    .|| .||:
Mouse   689 PEISEASLMSNLPLTSEASPVSNLPLTSEASPMSDLPPTSETSSESSMPLTS----ETPFVSSLP 749

  Fly   681 --TSTSCTSSSSSSASMSSSCSSSNSG------------------------------STTTAPTT 713
              ..||..|:||.:..|......|.||                              ||...|..
Mouse   750 IPAETSPISNSSVNERMVHQQRKSPSGSEEANSPQKEEPSIPTKPLGESLVSHPKPLSTIPEPIN 814

  Fly   714 SSSAGAP---------------------------------------------------------T 721
            .|||..|                                                         :
Mouse   815 MSSAMVPEALPPEGLHSQTLSQEPCNAHVEMEKLYASSIPELPSSEMTKVKNHSVLQRPEKKGLS 879

  Fly   722 APLTLAAAAETTLANVQAMLSTVAKLQQQQQELPV------ELNSNEMYQH-------------- 766
            |||.:...:|.|  ..:.:....||||.:|....|      |.:.|::::.
Mouse   880 APLEVPVFSEET--ETKGIELPPAKLQDKQYAPSVDKATFLEGSRNKIHKQSSTLNRLETSHTSK 942

  Fly   767 -------------------------VQHDWNFGDIK----------------------------- 777
                                     |:|  :||..|
Mouse   943 VSEPSKSPDGIRNDNRESEISKRKTVEH--SFGICKEKRARIEDDQSARSLASSSPPEKEQPPRE 1005

  Fly   778 ---------------------------------LSSSQSSG--------------DQQRNLSHEA 795
                                             .|:|.|||              .||.....||
Mouse  1006 EPRVPPLKIQLSKIGPPFIIKSQPVSKAESRASTSTSVSSGRNTGARTLADIKARAQQARAQREA 1070

  Fly   796 IDLMDVVQDADVIDDIMHNDVCHDVLGDEDEGDQ--------------------------EEDED 834
            .....|...|.::...|         |...||.:                          :..::
Mouse  1071 AAAAAVAAAASIVSGAM---------GSPGEGGKARTLAHIKEQTKAKLFAKHQSRAHLFQTSKE 1126

  Fly   835 DEVVECMTEEQQLIDEDSEA---------------------------VREIVDKLQQ-------- 864
            ..:....|:|..|..|.|..                           :|||...|||
Mouse  1127 TRLPSVSTKEDSLNMEASPTPETKMEGSTGVIIINPNCRSPSSKPTHIREITTVLQQPLNPPQIP 1191

  Fly   865 --------HQQQQNQQQHHQQLHIQDVVQLAQHSFMPQAHSEFGNDIGQEMLCDAVPMSAAEMEV 921
                    |....|....|....|..... :::|.:|..|:        :...:.:|||.....:
Mouse  1192 ETATDLSVHSSDDNIPVSHLTEKIVSSTS-SENSSVPILHN--------KSPINPIPMSVCSTAM 1247

  Fly   922 S--------------STVI--TNSSNSNDSSNNISL----------CSSTNSLTINQMPHQASQQ 960
            |              |:|:  .:|:||..|:.|||:          |.:.....||:.|..|:
Mouse  1248 SGAIKEHPFVSPVDKSSVLMSVDSANSTISACNISMLKSIQGSDAPCIALVPKCINRTPIPAA-- 1310

  Fly   961 PQQNAQSNAQQQRQILVDSN--GQIIG----------------NFLLQQQRQQQQQQLLQQFTLQ 1007
            |:...|||:...:.:||.|:  ..:|.                |.|...........:..:|..:
Mouse  1311 PEGTGQSNSMDGKALLVPSSKAANVISNQYTSVPAPTIASNLPNHLCTSSVLIPPTGINNRFVSE 1375

  Fly  1008 AAAAQQQQQQQQQHQQQQQQQQQATSSNSLGKTLPVALRNGTQQFLSPNLIAQQHQQQQQQQLEQ 1072
            ..|....::|               ::.|:|.|:..||..|....::.:|:.:
Mouse  1376 KIAMPGSEEQ---------------AAVSIGATMRTALSCGDSVAVTDSLVPR------------ 1413

  Fly  1073 HQQQATAQQKHQQIQQFALQQAQLHQRQLLAQAANNNL-----------LQQQQQQQQNVALPTT 1126
                       ..|..||......:......:.:..||           ..::.||.....:|.|
Mouse  1414 -----------SPIAMFAGNMLTANSYNCPPKLSGENLDNNSGPLNRTDNSEKPQQPAGGFVPAT 1467

  Fly  1127 QAKFIAKPLNII---SMTRPANASPTTAATTANTASIPSAYANVVAVTGAQQQQSPPVPAPQQQT 1188
            ..:.|  |..:|   |.|..:|.| .|.:..:..:|:.|...:|......|     ||..||...
Mouse  1468 INRSI--PCKVIVDHSTTLTSNLS-LTVSIESGDSSLDSQTRSVRTDVSIQ-----PVACPQVSV 1524

  Fly  1189 VQQQQLA-----NHNS--------------------NMQQLPNVLTMK----TLPPSGVPTTIAQ 1224
            :.:.:.|     :|.|                    ::::||..|..|    |:|..|    .|:
Mouse  1525 ISRPEQATSEGLDHGSVFIAAPTAKQDCKTLQATCTSLRELPLTLPDKLNEVTVPTHG----FAE 1585

  Fly  1225 QRLQPKMPTGKGRKATSNRLPPGAVNLERSYQICQA----------VIQNS--------PNRENL 1271
            |.........:...|.||:..||       .:||.:          |:.:|        |.:..|
Mouse  1586 QARNSSTFKKETDTACSNQYNPG-------NRICWSEDPMRNTAPPVVSHSSSSKQKEHPEQTGL 1643

  Fly  1272 KA------------QLRPPAAILN--------QH------------------------------- 1285
            ||            .|.|...|.|        .|
Mouse  1644 KAVKTEHVSYAHVSDLHPRNLITNVSLPVKPEPHEVDKGFRMDTEDFPGPERPPPVTEVTSSASV 1708

  Fly  1286 QPTTTTAPAPINPVTLNVSTVAATPMSNITTATGSMA--AAVAAAPP------QNVLKQEELLVS 1342
            |||.|..|:..:||...:| :|...:..|.:|:.|..  ::|.|..|      |..|..|::|..
Mouse  1709 QPTQTMKPSTTSPVEEAIS-LAPDTLKRIPSASSSSCRLSSVEANNPLVTQLLQGNLPLEKVLPQ 1772

  Fly  1343 GAVGA----GALPAGLPPNVMGVGRPGVYK--------------------VIGP----RMSGFPR 1379
            ..:||    ..||  ||.....||:.|:.:                    .:.|    :....|:
Mouse  1773 PRLGAKLEINRLP--LPLQTTSVGKTGLERNMVEMPSSSPNPDGKGYLAGTLAPVQMRKRENHPK 1835

  Fly  1380 KK-------YVQRKPSPTTLIRH--------VFSPGPGGATATAQQLQMLQQHHQSTTSPVPVQN 1429
            |:       :.|.|..|..::..        |.||       :..||...|...|...:...:.|
Mouse  1836 KRAARTVGDHAQVKCEPGKMVMEPDVKAVPCVISP-------SMSQLGHNQPFKQERLNKPSMAN 1893

  Fly  1430 PQQPAPE---------------QLIHQNGNGQYVLVHRANVGAADN----QAPRASSAP------ 1469
            ...|:||               .|.|.|.|..:    .|:.|.:..    |.|.|:..|
Mouse  1894 RIMPSPEVKQQKRLLPACSFQPSLFHVNKNEGF----HADTGTSHRQQFYQMPMAARGPLPTPAL 1954

  Fly  1470 -------PMHQNQFV----TVQNPLHSIN------------------------------------ 1487
                   |:..|.|.    ..|..|..:|
Mouse  1955 LQNSPKTPVGCNAFAFNRHLEQKALGDVNLPTAPHQLRLANMLSPNMPIKEGEDGGGTTHTMPSK 2019

  Fly  1488 ----------------------------------------GIPMGGRGRPASVDTT------AGS 1506
                                                    .:|...:..|.:::||      ..:
Mouse  2020 AVVHAPLPPPPPPPPPPPPPLALPPPPPPPPPLPPPLPTVEVPSDQKQPPVNMETTKRLSWPQST 2084

  Fly  1507 G---NVIAPPISATDALHHHHHEMQQQQQHQQPQPLGNVGAAANIVRRNIAAGPNIAYIDGSNTN 1568
            |   |:.:.|:|..::|........:|..:.|           |.|:..:.|      ....|.:
Mouse  2085 GICSNIKSEPLSFEESLSSSCELGMKQVPYDQ-----------NEVKEQLKA------FALKNAD 2132

  Fly  1569 SSAVALMEAGNNYIVTTNASPTAAPSPINQQP--QSQPT---GTQH------------------Q 1610
            .|:..|.|....:   |..:....|.| .|||  .|.||   |:.:                  .
Mouse  2133 FSSYLLSEPQKPF---TQLAAQKLPVP-QQQPLCGSYPTIHFGSTNFKRAASAIEKSIGILGSGS 2193

  Fly  1611 HPLLQLHQTGENTPPGNEATATANN-------CACSLNAMVICQQCGAFCHDDCIGAAKLCVACV 1668
            :|......||:||....:..|..:|       |:|.|.||::|:.|||||||||||.:||||||:
Mouse  2194 NPATSTGLTGQNTQMPVQNFADNSNADELELKCSCRLKAMIVCKGCGAFCHDDCIGPSKLCVACL 2258

  Fly  1669 I 1669
            :
Mouse  2259 V 2259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asx	NP_001260969.1	ASXH	196..335	CDD:464041	67/138 (49%)
		PHD_3	1603..1669	CDD:316444	33/93 (35%)
Asxl3	XP_006525803.1	HARE-HTH	11..82	CDD:461541
		ASXH	236..361	CDD:464041	68/139 (49%)
		PHD_3	2204..2259	CDD:316444	27/54 (50%)