DRSC/TRiP Functional Genomics Resources

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Protein Alignment Asx and ASXL1

DIOPT Version :9

Sequence 1:NP_001260969.1 Gene:Asx / 36612 FlyBaseID:FBgn0261823 Length:1670 Species:Drosophila melanogaster
Sequence 2:XP_011526950.1 Gene:ASXL1 / 171023 HGNCID:18318 Length:1628 Species:Homo sapiens


Alignment Length:1790 Identity:344/1790 - (19%)
Similarity:555/1790 - (31%) Gaps:621/1790 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 LPRIIVKPIPPEKKPMAPSEEAAVSTAPAPPTRLICSRRIQQQQQVKAAAAAAAAAAAAAAAAAA 146
            |||:::.|:                                     |...|...:|:..:...|.
Human   256 LPRVVLTPL-------------------------------------KVNGAHVESASGFSGCHAD 283

  Fly   147 AAQAQATSSYPSAISPGSKAGTSQASTMREVLASIPGFSVKPRRRSNKKLTTAAQIEQTKDGKID 211
            ......:||...:::.||.|...||...::....:.||. ||         ...|:::.:..:||
Human   284 GESGSPSSSSSGSLALGSAAIRGQAEVTQDPAPLLRGFR-KP---------ATGQMKRNRGEEID 338

  Fly   212 LETPDSILASTNLRALLNKQTFSLLPPLYQYNLIQLLPSVDREASELEQPSSSASGGSPSEAIRL 276
            .|||.|||.:||||||:|.:||..||..:|..|:.|||.|||:.             .....:||
Human   339 FETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQV-------------GTDGLLRL 390

  Fly   277 SASCLNNEFFARACLEWRERLSEGEFTPENQLKLKTEAEREKNKLDPWKLKHFEPFWGEKNSRGK 341
            |:|.||||||..|...|||||::||||.|.|::::.|.|:|| |::.||.|.||.::|:|....|
Human   391 SSSALNNEFFTHAAQSWRERLADGEFTHEMQVRIRQEMEKEK-KVEQWKEKFFEDYYGQKLGLTK 454

  Fly   342 DKDKLESDCKNQKLSASIKSEPKPPATSQQKPLQQATCDNETELKFDLSTKCETTSAKTTVAVAV 406
            ::.                             |||.....|.|:|..|....|:.          
Human   455 EES-----------------------------LQQNVGQEEAEIKSGLCVPGESV---------- 480

  Fly   407 ADKSSTFPPTGSQNNVLNEQQRRVLKRPSSSPSQRKQAPTTIATINLDDDLDELPSTSKDSKQPK 471
              :....|.|..::....::.|..|:..:.....:||.             .|....:||:|...
Human   481 --RIQRGPATRQRDGHFKKRSRPDLRTRARRNLYKKQE-------------SEQAGVAKDAKSVA 530

  Fly   472 MDEIVPNASGNVVAAPMVDVVDHSAVEMKIKDEQQHQRQHQPLINSTCDKIEPSECSKEMIVAMK 536
            .|  ||                                                        ..|
Human   531 SD--VP--------------------------------------------------------LYK 537

  Fly   537 QVDSKEDVDSIASAAAMPAIAAVTPHTPKPEALAPNPDVANQFVSYLQNVELAAETKAPLDNSNE 601
            ..::|.|...::|           ||.|...:.||:          |:..|...|:.|....:..
Human   538 DGEAKTDPAGLSS-----------PHLPGTSSAAPD----------LEGPEFPVESVASRIQAEP 581

  Fly   602 ADITTGTNSHDFVFS---DTIDHAAYFQEHQSTINHNFFTSSSSS--------NTATTAANKLEE 655
            .::...:.|.|.:.|   :|:|     ||.:.....:|..::|:|        ....:..|.:|.
Human   582 DNLARASASPDRIPSLPQETVD-----QEPKDQKRKSFEQAASASFPEKKPRLEDRQSFRNTIES 641

  Fly   656 -HSDKPE---DSPL--PIASSISGSTPASSITSTSCTSSSSSSASMSSSCSSSNSGSTT------ 708
             |::||:   :.|.  ||...:|...|...:                       .|..|      
Human   642 VHTEKPQPTKEEPKVPPIRIQLSRIKPPWVV-----------------------KGQPTYQICPR 683

  Fly   709 TAPTTSSSAGAPTAPLTLAAAAETTLANVQAMLSTVAKLQQQQQELPVELNSNEMYQHVQHDWNF 773
            ..|||.||....|...|||                                              
Human   684 IIPTTESSCRGWTGARTLA---------------------------------------------- 702

  Fly   774 GDIKLSSSQSSGDQQRNLSHEAIDLMDVVQDADVIDDIMHNDVCHDVLG------------DEDE 826
             |||..:.|..|.:    .|..                 |.:.....:|            .::.
Human   703 -DIKARALQVRGAR----GHHC-----------------HREAATTAIGGGGGPGGGGGGATDEG 745

  Fly   827 GDQEEDEDDEVVECMTEEQQLIDEDSEAVREIVDKLQQHQQQQNQQQHHQQLHIQDVVQLAQHSF 891
            |.:.....|....|                       .|.:.:..                    
Human   746 GGRGSSSGDGGEAC-----------------------GHPEPRGG-------------------- 767

  Fly   892 MPQAHSEFGNDIGQEMLCDAVPMSAAEMEVSSTVITNSSNSNDSSNNISLC---SSTNSLTINQM 953
             |....:..:|:.:..|....|::....:..:.:.........|......|   .:|..||... 
Human   768 -PSTPGKCTSDLQRTQLLPPYPLNGEHTQAGTAMSRARREDLPSLRKEESCLLQRATVGLTDGL- 830

  Fly   954 PHQASQQPQQNAQSNAQQQRQILVDSNGQIIGNFLLQQQRQQQQQQLLQQFTLQAAAAQQQQQQQ 1018
             ..|||.|               |...|             .|..|.|...:.|.:.|::..:|.
Human   831 -GDASQLP---------------VAPTG-------------DQPCQALPLLSSQTSVAERLVEQP 866

  Fly  1019 QQHQQQQQQQQQATSS-----NSLGKTLPVALRNGTQQFLSPNLIAQQH-QQQQQQQLEQHQQ-- 1075
            |.|...:.:.:..|:|     ...|.|:|.  .||.    .|:|:.... ::...|.|:.|..  
Human   867 QLHPDVRTECESGTTSWESDDEEQGPTVPA--DNGP----IPSLVGDDTLEKGTGQALDSHPTMK 925

  Fly  1076 ---QATAQQKHQQIQQFALQQAQLHQRQLLAQAANNNLLQQQQQQQQNVALPTTQAKFIAKPLNI 1137
               ..|.....:......||.......  |....:...:::...:|:|:   .|:|......|:.
Human   926 DPVNVTPSSTPESSPTDCLQNRAFDDE--LGLGGSCPPMRESDTRQENL---KTKALVSNSSLHW 985

  Fly  1138 ISMTRPANASPTTAATTANTASIPSAYANVVAVTGAQQQQSPPVP--APQQQTVQQQQLANHNSN 1200
            |.:  |:|..........:...|||....|    |.:.:::.|.|  .|...|.::        .
Human   986 IPI--PSNDEVVKQPKPESREHIPSVEPQV----GEEWEKAAPTPPALPGDLTAEE--------G 1036

  Fly  1201 MQQLPNVLTMKTLPPSGVPT---TIAQQRLQPKMPTGKGRKATSNRLPPGAVNLERSYQICQAVI 1262
            :..|.::.::.|:|..|...   :..||....|:..    ...|..|.|...:.:.:......:.
Human  1037 LDPLDSLTSLWTVPSRGGSDSNGSYCQQVDIEKLKI----NGDSEALSPHGESTDTASDFEGHLT 1097

  Fly  1263 QNSPNRENLKAQLRPPAAILNQHQPTTTTAPAPINPVTLNVSTVAAT------------------ 1309
            ::|...:..:|.:...:::....:|....: ||::.|..::..|..|                  
Human  1098 EDSSEADTREAAVTKGSSVDKDEKPNWNQS-APLSKVNGDMRLVTRTDGMVAPQSWVSRVCAVRQ 1161

  Fly  1310 --PMSNITTATGSMAAAVAAAPPQNVLKQEELLVSGAVGAGALPAG--LPP-------------- 1356
              |.|.:..:|.....||..:.|.:.::....||...: .|:||..  |||              
Human  1162 KIPDSLLLASTEYQPRAVCLSMPGSSVEATNPLVMQLL-QGSLPLEKVLPPAHDDSMSESPQVPL 1225

  Fly  1357 ---NVMGVGRPGVYKVIGPRMSGF-----PRKKYVQRKP-------SPTTLIRHVFSPGPGGATA 1406
               ...|..|.|....:| :.||.     |......::|       :.|.|.|...:..||....
Human  1226 TKDQSHGSLRMGSLHGLG-KNSGMVDGSSPSSLRALKEPLLPDSCETGTGLARIEATQAPGAPQK 1289

  Fly  1407 TAQQLQMLQQHHQSTTSPVPVQNPQQPAPEQLIHQNGNGQYVLVHRANVGAADNQAPRASS---- 1467
            ..:.:......|       ||.|| ..:..:|...:...|:     ::....|.:..||.|    
Human  1290 NCKAVPSFDSLH-------PVTNP-ITSSRKLEEMDSKEQF-----SSFSCEDQKEVRAMSQDSN 1341

  Fly  1468 ---APPMHQNQFVTVQNP-LHSINGIPMG----GRGRPASVDTTA------GSGNVIA------- 1511
               ||........|.:.| ..|.|.|..|    ||......:.|.      |||||.|       
Human  1342 SNAAPGKSPGDLTTSRTPRFSSPNVISFGPEQTGRALGDQSNVTGQGKKLFGSGNVAATLQRPRP 1406

  Fly  1512 ----------PPISATDALHHHHHEM----QQQQQHQQPQPLGNVGAAANIVRRNIAAGPNIAYI 1562
                      ||:..:..|....:.|    |..::...|:|...||:..|  .:....||..|..
Human  1407 ADPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPKPHAFVGSVKN--EKTFVGGPLKANA 1469

  Fly  1563 DGSN-TNSSAVALM-------------------EAGNNYIVTTNASPTAAPSPIN---------- 1597
            :... |..|.:.|:                   |.|..  ::....|::.||.::          
Human  1470 ENRKATGHSPLELVGHLEGMPFVMDLPFWKLPREPGKG--LSEPLEPSSLPSQLSIKQAFYGKLS 1532

  Fly  1598 ---------QQPQSQPT------------------GTQHQHPL-LQLHQTGENTPPGNEATATAN 1634
                     ....|.||                  |..|...| ||:. |..:|     ..:.:.
Human  1533 KLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGASHSASLSLQMF-TDSST-----VESISL 1591

  Fly  1635 NCACSLNAMVICQQCGAFCHDDCIGAAKLCVACVI 1669
            .|||||.||::||.|||||||||||.:||||.|::
Human  1592 QCACSLKAMIMCQGCGAFCHDDCIGPSKLCVLCLV 1626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AsxNP_001260969.1 ASXH 196..333 CDD:290630 60/136 (44%)
PHD_3 1603..1669 CDD:290633 34/84 (40%)
ASXL1XP_011526950.1 HARE-HTH 106..170 CDD:368272
ASXH 323..446 CDD:372815 62/145 (43%)
PHD_3 <1593..1626 CDD:316444 25/32 (78%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148434
Domainoid 1 1.000 129 1.000 Domainoid score I5241
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 250 1.000 Inparanoid score I3234
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm40705
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR13578
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4475
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
88.070

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