Protein Alignment Asx and asxl3

DIOPT Version :10

• Sequence 1: NP_001260969.1
• Gene: Asx / 36612
• FlyBaseID: FBgn0261823
• Length: 1670
• Species: Drosophila melanogaster
• Sequence 2: XP_004915257.2
• Gene: asxl3 / 100170177
• XenbaseID: XB-GENE-5858668
• Length: 2146
• Species: Xenopus tropicalis
• Alignment Length: 2116
• Identity: 419/2116 - (19%)
• Similarity: 684/2116 - (32%)
• Gaps: 684/2116 - (32%)

  Fly   113 TRLICSRRIQQQQQVKAAAAAAAAAAAAAAAAAAAAQAQATSSYPSAISPGSKAGTSQAS--TMR 175
            |:....:.::|||:.:...:.................:...|..||...  ||.|.:..|  ..:
 Frog   154 TKKALKQALRQQQRKRNGVSMMVNKTVPRVVLTPLKVSDEQSDSPSGSE--SKNGEADGSDKETK 216

  Fly   176 EVLASIPGFSVKPRRRSNKKLTTAAQIEQTKDGKIDLETPDSILASTNLRALLNKQTFSLLPPLY 240
            :...|.||.......:..|| :....::.||...||:|||.|||.:||||||:||.||:.||..:
 Frog   217 QGQKSPPGKQTSQHLKRLKK-SGLGHLKWTKAEDIDIETPGSILVNTNLRALINKHTFASLPQHF 280

  Fly   241 QYNLIQLLPSVDREASELEQPSSSASGGSPSEAIRLSASCLNNEFFARACLEWRERLSEGEFTPE 305
            |..|:.|||.|||:.            ||.. |:|||.|.|||||||.|...|::||||||||||
 Frog   281 QQYLLLLLPEVDRQM------------GSDG-ALRLSNSALNNEFFAYAAQGWKQRLSEGEFTPE 332

  Fly   306 NQLKLKTEAEREKNKLDPWKLKHFEPFWGEKNSRGKDKDKLESDCKNQKLSASIKSEPKPPATSQ 370
            .|::::.|.|:|| |.:.||.:.||.|:|||:...|::              ||:      ..|.
 Frog   333 MQMRIRQEIEKEK-KTELWKERFFERFYGEKSGMSKEE--------------SIE------LASG 376

  Fly   371 QKPLQQATCDNETELKFD-LSTKCETTSAKTTVAVAVADKSSTFPPTGSQNNV-----LNEQQRR 429
            |...:......||.|.|. .||:|:.::........:.||......||:..:|     ::|.:..
 Frog   377 QNSSEDEISSLETSLSFSGPSTQCKKSAKNNNETPVLIDKGVLEESTGTLKDVPSKGLISETELE 441

  Fly   430 VLKRPSSSPSQRKQAPTTIATINLDDDLDELPST-------SKDSKQPKM-------------DE 474
            .:.....|..|.:.|.....||....::||...|       ::|:|:.:.             |:
 Frog   442 DIVISEESVIQEEIAEEVETTICDCQEVDERTETELPEELENQDTKEEEKGILENVEPCVVMEDD 506

  Fly   475 IVPNASGNV---------------VAAPMVDVVDHS-AVEMKIKDEQQHQRQHQPL-------IN 516
            |:||:...|               .|.||......| |:.......:...:..|||       .|
 Frog   507 ILPNSDVKVKGEAKSEDLECDMLEEANPMAKCSPSSPALSSHGSPSESVDKDSQPLPELNISEEN 571

  Fly   517 STCDKIEPSECSKE-MIVAMKQVDSKEDVDSIASAAAMPAIAAVTPH-----TPKP----EALAP 571
            .:...:..:|||:| ..|.|:.:...::..|.|:..:..:.::.:|.     .|.|    ::.:.
 Frog   572 DSYSALVQAECSEEATAVEMELISEPDEQFSEAACVSETSFSSESPEEACNSIPSPCGDTQSASE 636

  Fly   572 NP----DVANQF---VSYLQNVELAAETKAPLDNSNEADITTGTNSHDFVFSDTIDHAAYFQEHQ 629
            :|    .|...|   ||..:|||..::.| .:|.|....:|          ||
 Frog   637 DPYTPASVEAAFLSEVSSFENVESESQQK-HVDESPPTSLT----------SD------------ 678

  Fly   630 STINHNFFTSSSSSNTATTAANKLEEHSDKPEDSP---LPIASSISGSTPASSITSTSCTSSSSS 691
                    .|..||:...:.|:....|....|.||   ||:.|..|   |.|.:..||.|||.||
 Frog   679 --------ISPVSSSPIRSEASPSSNHPLTSEASPASNLPLTSEAS---PMSDVPFTSETSSVSS 732

  Fly   692 SASMS-----------SSCSSSNSGSTT--------TAPTTSSSAGAPTAPLT------------ 725
            .|..|           |..||..|..|.        .:||:|..:.:||...|
 Frog   733 VALASETGLSTIVPPPSEASSVYSPPTNEHLMLQQDVSPTSSDESQSPTKDETDDFSEASQVDAI 797

  Fly   726 -----------LAAAAETTLANVQAMLSTVAK-------LQQQQQELPVELNSNEMYQHVQ---- 768
                       |:.:....:.|.:...|.|.|       ..::..|:....|.:..|:.|:
 Frog   798 SEQEIPENLNYLSESLNEEILNQKHCPSAVEKDKPYTSASSEKCPEIITIKNDSTHYRIVEKKYL 862

  Fly   769 --HDWNFGDI--KLSSSQSSGDQQRNLSHEAIDLMDVVQDADVIDDIMHNDVC----HDVLGDED 825
              ||.:.|..  |..|:|..       |||.:...:|.....|       :.|    |...|...
 Frog   863 PSHDDSQGFFCKKTDSTQFK-------SHEKLHATNVEMTGYV-------ESCRSKSHKQQGSSQ 913

  Fly   826 EGDQEEDEDDEVVE-----------------------CMTEEQQLIDED---------SEAVREI 858
            ....:..|..:.||                       .:.|::..||:|         |:|.||
 Frog   914 MSHTKSSEHSKQVEPIRTETREPELSKRKTLELHNFGILKEKRPRIDDDYHIRTSSVSSQAERE- 977

  Fly   859 VDKLQQHQQQQNQQQHHQQLHIQ------------DVVQLAQHSFMPQAHSEFGNDIGQEMLCD- 910
                   .....::.....|.||            ..:...:......|.:..|.:.|...|.|
 Frog   978 -------PPPPREEPKVPPLKIQLSKIGPPFIIKSQPIPKLESKMSSNASTSGGRNTGARTLADI 1035

  Fly   911 --AVPMSAAEMEVSSTVITNSSNSNDSSNNISLCSSTNSLTINQM----------PHQASQQPQQ 963
              ....:.|:.|.::.....::.|..|....|.|.||.:.|:..:          .|||....||
 Frog  1036 KARAQQARAQREAAAAAAVAAAASIVSGGVGSPCESTKTRTLAHIKEQTKAKLFAKHQAKVSVQQ 1100

  Fly   964 NAQSNAQQQRQILVD-----------SNGQIIGNFLLQQQRQQQQQQLLQQFTLQAAAAQQQQQQ 1017
            :::....::...:.|           |.|.||.|...:....:.........|||.:.:.....:
 Frog  1101 SSKEGKAKESHPVTDVPLSSDGKVESSTGVIIINPNCKSPNSKSTLHRELPSTLQKSLSNASLSE 1165

  Fly  1018 QQQHQQQQQQQQQATSSNSLGKTLPVALRN--GTQQFLSPNL---------IAQQHQQQQQQQLE 1071
            ...........:.....:|..||:.....:  |.....|.|:         |....::.......
 Frog  1166 TDSDASVHSSNENIHVPHSSDKTITSTSNDNCGVSTHFSKNIGPVSSVDSSITNTLEKSSVLMSI 1230

  Fly  1072 QHQQQATAQQKHQQIQQFALQQAQLHQRQLLAQAANN--------NLLQQQQQQQQNVALPTTQA 1128
            .::...|.:.....|     ||..:....::...:||        |....:......|::..:.|
 Frog  1231 DNENTTTVRCVLNSI-----QQTNIPGIGVVPVCSNNTSSPALAINSTTSKSTDDMRVSVTNSNA 1290

  Fly  1129 -KFIAKPLNII--SMTRPANASPTTAATTANTASIPSAYANVVAVTGAQQQQSPPVPAPQQQTVQ 1190
             :|.:.|:..|  ||..|:..| :...:..:|.|..:.....|.:.|.:::....|.:..::...
 Frog  1291 NQFTSVPVTSIGNSMLNPSLCS-SFLNSLNSTMSTGNRLPEKVNLPGCEKENDIKVCSSVKRMSS 1354

  Fly  1191 QQQLANHNSNMQQLP----NVLTMK---------------------------------------- 1211
            |:.:..::.:..|:|    |..|:.
 Frog  1355 QEDIIFNSLDRSQVPLFTNNRRTLSSDSNQISIDNLDKSLCSVVSDFHNKALPVTLSQASTNRSI 1419

  Fly  1212 ---------TLPPSGVPTTI--AQQRLQPKMPTGKGRKATSNRLPPGAVNLERSYQI-------- 1257
                     |.|.|..|.|:  ::..:.|:...|:...:..|:..|....:.|...:
 Frog  1420 PCKVIVDHCTTPNSSFPFTVENSESCIDPQNMHGRAELSMQNKACPQVSVISRQESLPSDSSEHS 1484

  Fly  1258 -----------------CQAVIQNS-------PNRENLKAQLRPPAAIL---------------- 1282
                             |...::||       ..|||...||:.|.:::
 Frog  1485 SFSNISSKLARDERNASCTGHLKNSYFQEKSVACRENYNEQLKCPPSLMSCADNNSEYISNNRIC 1549

  Fly  1283 ----------------------------------NQHQPTTTTAPAPINPVTLNV---------- 1303
                                              :.||........|:..:|:::
 Frog  1550 WNEKDKSVGNHLNMSKHIGFSGENILSSVKSEPDSYHQMAKVNTVTPVPSITVSIKSEASETTKC 1614

  Fly  1304 ---------STVAATPMSNITTATGSMAAAVAAAPPQNVLKQEELLVSGAVGAGALPAGLPPNVM 1359
                     |.::.|...:|...:..:...|:...|.::..:....|:.|..:....:.:..|..
 Frog  1615 FGNDGYAGQSALSQTANLDIGAQSSDIPVTVSRDEPLSLTTENLKRVTNAGSSSCRLSSVEANNP 1679

  Fly  1360 GV-----GRPGVYKVI-GPRMSGFPRKKYVQRKP-----------SPTTLIRHVFSPGPGG---- 1403
            .|     |...:.||: .||:.   .|..:.|.|           |..|...:..||.|.|
 Frog  1680 LVTQLLQGNLPLEKVLPQPRLG---TKLEISRLPLQATSMYKATASDRTASENPCSPTPDGKVYP 1741

  Fly  1404 -----------------ATATAQQLQM-------------------------------------L 1414
                             |....:|.|:                                     :
 Frog  1742 LTPLQIRKRENHPKKRMARTVGEQTQIKCESGKLSMDADQALSSCMMGSNMNSLVQGQGFKQEWM 1806

  Fly  1415 QQHHQSTT---SPVPVQNPQQPAPEQLIHQN-----GNGQYVLVHRANVGAADNQAPRASSAPPM 1471
            .:|...|.   || .::..::|.|.....||     .||.|   |           |.||::...
 Frog  1807 NKHTVQTRIAHSP-EIKQQKRPLPSCSFQQNLYNVEKNGSY---H-----------PEASTSHRQ 1856

  Fly  1472 HQNQFVTVQN--------PLHSINGIPMGG----------------RGRPASVDTTAGSGNVIAP 1512
            |..|....|.        |..|:...|.|.                ..:|.|:    |.||..:|
 Frog  1857 HFYQMSLAQRGSAPSVYLPQGSVKAQPSGNAFAFSRHPEQKALAEINLQPLSL----GLGNAYSP 1917

  Fly  1513 --PISATDALHHHHHEMQQQQQHQQPQPLGNV-------GAAANIVRR--------NIAAGPNIA 1560
              .|...|.|.:....:|.:.....|.|...|       ..|....:|        ||...|| :
 Frog  1918 NLHIKEGDDLGNPSQTLQHKFLVHPPLPNSEVPPDQKQPAVAMETTKRLSWSQPTSNIKTEPN-S 1981

  Fly  1561 YIDGSNTNSSAVALMEAG--------------------NNYIVTTNASPTAAPSPINQQPQSQPT 1605
            |.||.| ||..:.:.:|.                    ::|:::....|.:..:.  |:.|:|..
 Frog  1982 YEDGLN-NSCELTMKQASYEQNEVKEQLKAFALKNADFSSYLLSEPQKPFSQLAA--QKVQTQQL 2043

  Fly  1606 GTQHQ---HPLLQLHQT---------------------------GENTP-------PGNEATATA 1633
            ..|||   :|.:....|                           .:|||       ..:.|....
 Frog  2044 PQQHQGGSYPAIHFGSTSFKRAASAIEKSIGILGSNSKSASGLSSQNTPIPVQNFADSSSADELE 2108

  Fly  1634 NNCACSLNAMVICQQCGAFCHDDCIGAAKLCVACVI 1669
            ..|:|.|.||::|:.|||||||||||.:||||||::
 Frog  2109 LKCSCRLKAMIVCKGCGAFCHDDCIGPSKLCVACLV 2144

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asx	NP_001260969.1	ASXH	196..335	CDD:464041	67/138 (49%)
		PHD_3	1603..1669	CDD:316444	33/102 (32%)
asxl3	XP_004915257.2	HARE-HTH	11..82	CDD:461541
		ASXH	236..361	CDD:464041	68/139 (49%)
		PHA03307	540..>775	CDD:223039	61/268 (23%)
		PHD_3	2089..2144	CDD:316444	27/54 (50%)