Protein Alignment Asx and asxl2

DIOPT Version :9

• Sequence 1: NP_001260969.1
• Gene: Asx / 36612
• FlyBaseID: FBgn0261823
• Length: 1670
• Species: Drosophila melanogaster
• Sequence 2: XP_005158912.1
• Gene: asxl2 / 100150267
• ZFINID: ZDB-GENE-100412-1
• Length: 1211
• Species: Danio rerio
• Alignment Length: 1693
• Identity: 338/1693 - (19%)
• Similarity: 519/1693 - (30%)
• Gaps: 660/1693 - (38%)

  Fly    55 DDEKDPLALEQLEVSPSTKHTHSL--------RRHLPRIIVK----PIPPEKKPMAPSEEAAVST 107
            ||..|      :..|..|::|.|.        ||...|:..|    |..|:.:..:||..::...
Zfish    99 DDSSD------MSDSRCTENTSSTGYSKDGRRRRWTRRVPTKLQSQPSSPQSRCSSPSVSSSKLM 157

  Fly   108 APAPP-TRLICSRRIQQQQQVKAAAAAAAAAAAAAAAAAAAAQAQATSSYPSA----------IS 161
            :|:.. ::....:.::||||.........:.|::........:..|..|..|:          .|
Zfish   158 SPSQKHSKKALKQALKQQQQRNQRRQCGISNASSPRLLLKTVKDMAHDSSKSSWELKKSERCPAS 222

  Fly   162 PGSKAGTSQASTMREVLASIPGFSVKPRRRSNKKLTTAAQIEQTKDGKIDLETPDSILASTNLRA 226
            |.:...:|.:|...:|..:  ..:.|..:||::  ..|.|:.::: .:||:|||||||.:|||||
Zfish   223 PHNSTSSSSSSVKADVCHT--SSARKVSQRSSR--LNARQLRRSR-CEIDVETPDSILVNTNLRA 282

  Fly   227 LLNKQTFSLLPPLYQYNLIQLLPSVDREASELEQPSSSASGGSPSEAIRLSASCLNNEFFARACL 291
            |:||.||||||...|..|:::||.||::|             |...|:::::|.||||||..|..
Zfish   283 LINKHTFSLLPTDCQQKLLKMLPEVDQQA-------------SMDGALKVTSSALNNEFFTSAAQ 334

  Fly   292 EWRERLSEGEFTPENQLKLKTEAEREKNKLDPWKLKHFEPFWGEKNSRGKDKDKLESDCKNQKLS 356
            .|:|||||||||||.:|:::.|.|:|| |:|.||.:.||.::||
Zfish   335 SWKERLSEGEFTPELRLRMRQEIEKEK-KVDLWKEQFFESYYGE--------------------- 377

  Fly   357 ASIKSEPKPPATSQQKPLQQATCDNETELKFDLSTKCETTSAKTTVAVAVADKSSTFPPTGSQNN 421
                              ....|..|::         |.|.||
Zfish   378 ------------------HSGLCIEESK---------ELTEAK---------------------- 393

  Fly   422 VLNEQQRRVLKRPSSSPSQRKQAPTTIATINLDDDLDELPSTSKDSKQPKMDEIV--PNASGNVV 484
                                                 |||..:|.:..|...|||  |..
Zfish   394 -------------------------------------ELPEPAKKAVVPVKPEIVIEPRK----- 416

  Fly   485 AAPMVDVVDHSAVEMKIKDEQQHQRQHQPLINSTCDKIEPSECSKEMIVAMKQVDSKEDVDSIAS 549
            ..|:::|:........:|....|....:|:      |:..||.|:      ..:|:|:||
Zfish   417 VNPVIEVIHMELRSRDVKSTVMHTSPEEPV------KLPASEKSR------LSLDTKKDV----- 464

  Fly   550 AAAMPAIAAVTPHTPKPEALAPNPDVANQFVSYLQNVELAAETKAPLDNSNEADITTGTNSHDFV 614
                  :..:.|.:...:.:.|.||..       :.:|.....|.|
Zfish   465 ------LVELIPVSSTQKMVDPKPDSE-------KTLESEIRCKTP------------------- 497

  Fly   615 FSDTIDHAAYFQEHQSTINHNFFTSSSSSNTATTAANKLEEHSDKPEDSPLPIASSISGSTPASS 679
                                     :|......|...:.|.||.| |:||      :||:..|.:
Zfish   498 -------------------------TSPLEAMVTCLKRKETHSTK-EESP------VSGAGQALT 530

  Fly   680 ITSTSCTSSSSSSASMSSSCSSSNSGSTTTAPTTSSSAGAPTAPLTLAAAAETTLANVQAMLSTV 744
                                ..:..|||.||.|:.        ||
Zfish   531 --------------------ERNKGGSTATAVTSE--------PL-------------------- 547

  Fly   745 AKLQQQQQELPVELNSNEMYQHVQHDWNFGDIKLSSSQSSGDQQRNLSHEAIDLMDVVQDADVID 809
                                                       :|.:|.|        |||:||
Zfish   548 -------------------------------------------KRKISSE--------QDAEVI- 560

  Fly   810 DIMHNDVCHDVLGDEDEGDQEEDEDDEVVECMTEEQQLIDEDSEAVREIVDKLQQHQQQQNQQQH 874
                         .|.:......|:...|....:.:|.:......|..|:          :....
Zfish   561 -------------TEKKPRSSSPEESPTVTAKEKLEQRVPPLKIPVSRIL----------SAPAS 602

  Fly   875 HQQLHIQDVVQLAQHSFMPQAHSEFGNDIGQEMLCD---AVPMSAAEMEVSSTVITNSSNSNDSS 936
            .:|:..:..|.|...|..|       ...|...|.|   ...::.|:...::...::||....|.
Zfish   603 IEQISPRTPVPLTPPSVRP-------GRTGARTLADIKAKAQLARAQRAAAAAARSSSSKGTGSV 660

  Fly   937 NNISLCSSTNSLTINQMPHQASQQPQQNAQSNAQQQRQILVDSNGQIIGNFLLQQQRQQQQQQLL 1001
            ...|..|...||:.:..|          |.|.:|....|.:.|.          ....:....|.
Zfish   661 GGTSTPSPARSLSEDFSP----------ASSKSQSVSPIKLSSG----------SPAPEGTVTLS 705

  Fly  1002 QQFTLQAAA-------AQQQQQQQ---QQHQQQQQQQQQATSSNSLGKTLPVAL-RNGTQQFLSP 1055
            |.|....:|       ||.....|   ::::.....|....|.|.:||.....| ..||   |:|
Zfish   706 QTFPSSGSAGYTDPVFAQAFSASQGFLKENRSSFGLQTTQCSLNPIGKDQHYLLCPEGT---LAP 767

  Fly  1056 ----------NLIAQQHQQQQQQQLEQHQQQATAQQKHQQIQQFALQQAQLHQRQLLAQAANNNL 1110
                      |.|||  .|:.||.|                  ||...|    .:|::....||.
Zfish   768 SGQAGNVTVSNTIAQ--SQRPQQTL------------------FAGASA----AKLISSIPENNP 808

  Fly  1111 LQQQQQQQQNVALPTTQAKFIAKPLNIISMTRPANASPTTAATTANTASIPSAYANVVAVTGAQQ 1175
            |..|..|.:.|.|    .|.:.|||        .||...:.|.:|...      .|:...|...:
Zfish   809 LVTQLLQGKEVPL----EKILPKPL--------TNAEVQSVAISARDK------GNLDTTTAGWK 855

  Fly  1176 QQSPPVPAPQQQTVQQ-QQLANHNSNMQQLPNVLTMKTLPPSGVPTTIAQQRLQPKMPTGKGRKA 1239
            :.||        |:|: .:..|.....|....|.:.......|....|.|       |..:.:..
Zfish   856 KDSP--------TIQEVSKFVNQVPFDQPAKQVSSRDKFVKVGTQDRILQ-------PLREQKHT 905

  Fly  1240 TSNRLPPGAVNLERSYQICQAVIQNSPNRENLKAQLRPPAAILNQHQPTTTTAPAPINPVTLNVS 1304
            :|||         :|.|.....:.:..:.::....|    .|..:.:   .:.||......||||
Zfish   906 SSNR---------QSSQFHSCHLGHPESSQDQSVHL----GIFGRKR---ISKPAMTGHYLLNVS 954

  Fly  1305 TVAATPMSNITTATGSMAAAVAAAPPQNVLKQEELLVSGAVGAGALPAGLPPNVMGVGRPGVYKV 1369
            |......|:......|..:...|.     ||:|::....:|      .|...::.|....|
Zfish   955 TYGRGSESSKRPHQASNTSTTLAN-----LKKEKIEAEDSV------KGTTESLAGTTSQG---- 1004

  Fly  1370 IGPRMSGFPRKKYVQR-----------KPSPTTLIRHVFSPGP-----------GGATATAQQLQ 1412
                .:.||..|..|:           .|.|.|.::   |..|           ..:|.|.:...
Zfish  1005 ----HAPFPSVKVEQQGCFISKPDDGLAPQPCTDVK---SESPSLSCLSSKEEGSSSTRTKETCS 1062

  Fly  1413 MLQQHHQSTTSPVPVQNPQQPAPEQLIHQNGNGQYVLVHRANVGAADNQAPRASSAPPMHQNQFV 1477
            ..|....||     :|...:|             |.|                   ...||..|:
Zfish  1063 KGQLDMCST-----IQGKTEP-------------YQL-------------------SDCHQRMFL 1090

  Fly  1478 TVQNPLHSINGIPMGGRGRPASVDTTAGSGNVIAPPISATDALHHHHHEMQQQQQHQQPQPLGNV 1542
                |..:.||...||     |:.            :|...||:|        .....|...|
Zfish  1091 ----PQKAHNGTQYGG-----SIS------------MSVPHALNH--------SMPDTPSCSG-- 1124

  Fly  1543 GAAANIVRRNIAAGPNIAYIDGSNTNSSAVALMEAGNNYIVTTNASPTAAPSPINQQPQSQPTGT 1607
                                ||.......:       ::.||....|..
Zfish  1125 --------------------DGETAGGGMM-------SFSVTVTTIPAG---------------- 1146

  Fly  1608 QHQHPLLQLHQTGENTPPGNEATATA------NNCACSLNAMVICQQCGAFCHDDCIGAAKLCVA 1666
               |.|.|..|  ..|.|......|:      :.|.|.|.||::|:.|||||||||||.:||||:
Zfish  1147 ---HLLDQSSQ--RETSPEEAFIETSGMEDVQSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVS 1206

  Fly  1667 CVI 1669
            |::
Zfish  1207 CLV 1209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asx	NP_001260969.1	ASXH	196..333	CDD:290630	65/136 (48%)
		PHD_3	1603..1669	CDD:290633	29/71 (41%)
asxl2	XP_005158912.1	HARE-HTH	11..82	CDD:282869
		ASXH	255..375	CDD:290630	65/134 (49%)
		PHD_3	<1174..1209	CDD:290633	22/34 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582310
Domainoid	1	1.000	125	1.000	Domainoid score	I5419
eggNOG	1	0.900	-	-		E1_28Q0U
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3326
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007407
OrthoInspector	1	1.000	-	-		otm26369
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13578
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4475
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.970