Protein Alignment Asx and asxl2

DIOPT Version :10

• Sequence 1: NP_001260969.1
• Gene: Asx / 36612
• FlyBaseID: FBgn0261823
• Length: 1670
• Species: Drosophila melanogaster
• Sequence 2: XP_017945488.2
• Gene: asxl2 / 100137099
• XenbaseID: XB-GENE-996283
• Length: 1472
• Species: Xenopus tropicalis
• Alignment Length: 1746
• Identity: 382/1746 - (21%)
• Similarity: 572/1746 - (32%)
• Gaps: 592/1746 - (33%)

  Fly    68 VSPSTKHT----------HSLRRHLPRIIVKPIPPEKKPMAPSEEAAVSTAPAPPTRLICSRRIQ 122
            :|||.||:          ...|:...:.:..|:|..::.:..:.:.|.:.|||.||
 Frog   173 ISPSQKHSKKALKQALKQQQQRKKQQQRVGMPVPASQRLLLTTVKTANNVAPAKPT--------- 228

  Fly   123 QQQQVKAAAAAAAAAAAAAAAAAAAAQAQATSSYPSAISPGSKAGTSQASTMREVLASIPGFSVK 187
                            ......|...:.||::::.||.|     |||        |||:.|...|
 Frog   229 ----------------PTHTWEAKQPEGQASNAHISAPS-----GTS--------LASLHGLGKK 264

  Fly   188 PRRRSNKKLTTAAQIEQTKDGKIDLETPDSILASTNLRALLNKQTFSLLPPLYQYNLIQLLPSVD 252
            ...||::  ..|..|::||..:||:|||||||.:||||||:||.||||||...|..|:.|||.||
 Frog   265 ALPRSDR--LQARHIKRTKCAEIDVETPDSILVNTNLRALINKHTFSLLPGDCQQRLLLLLPEVD 327

  Fly   253 REASELEQPSSSASGGSPSEAIRLSASCLNNEFFARACLEWRERLSEGEFTPENQLKLKTEAERE 317
            |..             .|...::|::|.||||||..|...|:|||||||||||.||:::.|.|:|
 Frog   328 RPT-------------GPDGLMKLNSSALNNEFFTSASQSWKERLSEGEFTPEMQLRIRQEIEKE 379

  Fly   318 KNKLDPWKLKHFEPFWGEKNSRGKDKDKLESDCKNQKLSASIKSEPKPPATSQQKPLQQATCDNE 382
            | |::.||.:.:|.::||.:....|..|......|..|:.:..|.||          :|...|..
 Frog   380 K-KVESWKERFYESYYGENSGLNPDDYKELIAETNDTLARTQVSPPK----------EQCKSDPC 433

  Fly   383 TELKFDLSTKCETTSAKTTVAVAVADKSSTFPPTGSQNNVLNEQQRRVLKRPSSSPSQRKQAPTT 447
            .||: .:..|.|||:.|.                      :||           .|..:|:...|
 Frog   434 PELQ-PVEAKVETTAQKG----------------------INE-----------GPPIKKEDEGT 464

  Fly   448 IATINLDDDLDELPSTSKDSKQPKMDEIVPNASGNVVAAPMVDVVDHSA-VEMKIKDEQQHQRQH 511
            :..      ..||| |:.|:::|  .|::|..:...|:...|...:.:| |...:..::
 Frog   465 VHV------KAELP-TAGDTQRP--PEVMPADTKEKVSTVPVKTAEGAAEVITPVPSKE------ 514

  Fly   512 QPLINSTCDKIEPSECSKEMIVAMKQVDSKEDVDSIASAAAMPA-----IAAVTPHTPKPEALAP 571
                  |..||.|               ..|:.||.:.....|.     :....|.||..:|.
 Frog   515 ------TGHKISP---------------KPEETDSESQGTPTPTPLTSPVHMQPPSTPTAKAA-- 556

  Fly   572 NPDVANQFVSYLQNVELAAETKAPLDNSNEADITTGTNSHDFVFSDTIDHAAYFQEHQSTINHNF 636
             |...:......:.||||..|:.    ..:.|:..|.       ||.........|.|. |...|
 Frog   557 -PAQGSGAEGSPEKVELAIGTRV----KRKLDVGAGD-------SDNAGKCIRISEQQE-IQRPF 608

  Fly   637 --FTSSSSSNTATTAANKLEEHSDKPEDSPLPIASSISGSTPASSITSTSCTSSSSSSASM--SS 697
              ..|.|:..||..:..|:         .||.|        |.|.:.:....||..||...  ::
 Frog   609 RDLCSPSTKGTAQGSEQKV---------PPLKI--------PVSWLPTKPFPSSRVSSRPYFPTT 656

  Fly   698 SCSSSNSGSTTTAPTTSSS--AGAPTAPLTLAAAAETTLANVQAMLSTVAKLQQQQQELPVELNS 760
            ..|.|.:|:.|.|...:.:  |.|..|    ||||..|.|.: ::.|:|..........|
 Frog   657 GTSPSRTGARTLADIKAKAQLARAQRA----AAAAAATSAGL-SVGSSVPGPGPGGGTGP----- 711

  Fly   761 NEMYQHVQHDWNFGDIKLSSSQSSGDQQRNLSHEAIDLMDVVQDADVIDDIMHNDVCHDVLGDED 825
                        .|..........|.:.||
 Frog   712 ------------GGGAGPGGGARPGGEARN----------------------------------- 729

  Fly   826 EGDQEEDEDDEVVECMTEEQQLIDEDSEAVREIVDKLQQHQQQQNQQQHHQQLHIQDVVQLAQHS 890
                                                                             
 Frog   730 ----------------------------------------------------------------- 729

  Fly   891 FMPQA-HSEFGNDIGQEMLCDAVPMSAAEMEVSSTVITNSSNSNDSSNNISLCSSTNSLTINQMP 954
              |.| .||.|:             .|..::|.||........|.:   :..|:.|:..|  |.|
 Frog   730 --PAAGTSETGH-------------RAGVLDVGSTGSWRGERGNPA---LPSCTQTSRET--QNP 774

  Fly   955 HQASQQPQQNAQSNAQQQRQILVDSNGQIIGNFLLQQQRQQQQQQLLQQFTLQAAAAQQQQQQQQ 1019
            .|.|  |...|::                               ||||:.:|           |.
 Frog   775 LQVS--PDSTART-------------------------------QLLQKSSL-----------QP 795

  Fly  1020 QHQQQQQQQQ-------QATSSNSLGKTLPVALR----NGTQQFLSPNLIAQQHQQQQQQQLEQH 1073
            :|.....|..       .|.||.|:....|::.|    :||   ::|.:.|          :...
 Frog   796 RHPITGAQASLAYGCPLPARSSASIRMPNPLSDRLVATSGT---VAPGVTA----------IPPS 847

  Fly  1074 QQQATAQQKHQQIQQFALQQAQLHQRQLLAQAANNNLLQQQQQQQQNVALPTTQAKFI-AKPLNI 1137
            ....::.|..:.|:  |...||:..|..|..........:....:....:|...|:.| .||...
 Frog   848 STSCSSPQNLKGIR--ANLAAQIRPRISLGTQTIPPRPTETVPPKPAETIPPKPAETIPPKPAET 910

  Fly  1138 ISMTRPANASPTTAATTANTASIPSAYANVVAVTGAQQQQSPPVPAPQQQTVQQQQLANHNSNMQ 1202
            |. .|||...|...|.|     ||...|..:....|  :..||.||   :|:..:
 Frog   911 IP-PRPAETIPPRPAET-----IPPRPAETIPPRPA--ETIPPRPA---ETIPPR---------- 954

  Fly  1203 QLPNVLTMKTLPPSGVPTTIAQQRLQPKMPTGKGRKATSNRLPPGAVNLERSYQICQAVIQNSPN 1267
                  ..:|:||....|.       |..|.........:.:||..|       :.|||..|...
 Frog   955 ------PAETIPPRPAETI-------PPRPAETIPPRPVDTIPPRPV-------LSQAVTSNLST 999

  Fly  1268 RENLKAQLRPPAAI-LNQHQPTTTTAPAPI-NPVTLNVSTVAATPMSNITTATGSMAAAVAAAPP 1330
            ....:|..:|...| ..|..|..|.:..|. ||:...:....:.||..|.              |
 Frog  1000 PAKAQAPSQPAGPIPSTQRVPIRTGSSIPANNPLVTQLLQGKSVPMEQIM--------------P 1050

  Fly  1331 QNVLKQEELLVSGAVGAGALPAGLPPNVMGVGRPGVYKVIGPRMSGFPRKKYVQ----------R 1385
            :.:.|.|...:  .:|:|....  ..|..||..|....::....|..|....||          :
 Frog  1051 RPLNKMEVKTI--PIGSGQKER--VTNTAGVSAPAGGIMVSREDSEKPSHMAVQQLERFLSQNRQ 1111

  Fly  1386 KPSPTTLIRHVF----------SPGPGGATATAQQLQMLQ------QHHQSTTSPVPVQNPQQPA 1434
            .||...::: :|          |.....|::|||: |.||      |..:|...|    ||.:|:
 Frog  1112 LPSSQRILQ-LFSGRDLSSISQSQSQEAASSTAQE-QTLQSLIRKVQQEKSLVGP----NPAEPS 1170

  Fly  1435 PEQLIHQN--------------GNGQYVLVHRANVGAADNQAPRASSAPPMH------------- 1472
            ......|.              .:|.| |::.|..|.......||.:..|..
 Frog  1171 ENTSASQRFMFGFVGRRTSKPAMSGHY-LLNIATYGRVPESFRRAQAVSPERGINLSDPERSQPR 1234

  Fly  1473 --QNQFVTVQNPLHSINGIPMGGRGRP------ASVDTTAGSGNVIAPPISATDALH-------- 1521
              :.:.||......:....|......|      .|..||..:..:.||.:...:.:.
 Frog  1235 DDETESVTESEEEENSENNPEDSEYAPRYLPIAVSHPTTLRTAKLEAPMLDLKETVQALSRGDIY 1299

  Fly  1522 ---HHHHEMQQQQQHQQPQPLG--NVGAAANIVRRNIA-AGPNIAYIDGSNTNSSAVALMEAGNN 1580
               |...:..|..|.:....||  ..|.|:.:.|.:.: .|....:.:..:|...|..:   |::
 Frog  1300 DESHIARDFIQAAQAKMVNVLGIKLKGDASELFRASKSHEGSQPPHSEQIHTGGPASLI---GSS 1361

  Fly  1581 YIVTTNASPTAAPSPINQQPQSQPTG-----------------------------TQHQHPL-LQ 1615
            |..|.|.:    .||...|..|.|||                             :.|..|: :|
 Frog  1362 YGGTINIT----TSPEGMQGPSIPTGGHLTPTSADNLVSFSVTVTTIPSSHIVDSSDHDQPVSVQ 1422

  Fly  1616 --LHQTGENTPPGNEATATANNCACSLNAMVICQQCGAFCHDDCIGAAKLCVACVI 1669
              ....|.:|.|        :.|.|.|.||:||:.|||||||||||.:||||:|::
 Frog  1423 AFTEDPGRDTAP--------SKCYCRLKAMIICKGCGAFCHDDCIGPSKLCVSCLV 1470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asx	NP_001260969.1	ASXH	196..335	CDD:464041	67/138 (49%)
		PHD_3	1603..1669	CDD:316444	32/97 (33%)
asxl2	XP_017945488.2	HARE-HTH	20..90	CDD:461541
		ASXH	273..396	CDD:464041	67/136 (49%)
		PRK07764	<718..1011	CDD:236090	83/512 (16%)
		PHA03247	<880..1081	CDD:223021	54/259 (21%)
		PHD_3	1413..1470	CDD:316444	29/64 (45%)