DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and Zfp423

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_001380647.1	Gene:	Zfp423 / 94188	RGDID:	621664	Length:	1292	Species:	Rattus norvegicus

Alignment Length:	1562	Identity:	403/1562 - (25%)
Similarity:	573/1562 - (36%)	Gaps:	565/1562 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRRKQAKPRACLKLGEKEDEENTGLLEPKEELLSGDEDNEDNEGEDEDEEVA--DEVAPEGGGG 63
            ||||||||||: :|:                           .|||..|..:|  ..||..||
  Rat     1 MSRRKQAKPRS-VKV---------------------------EEGEASDFSLAWDSSVAAAGG-- 35

  Fly    64 ERPQLVPNESQQQSWPTADEPAAPA-----AVAKEEEAEEGSEELQHPRDEVVASDAAANANGHC 123
                 :..||:      .|...:.|     :|..:||..|..|:::         |.:.....||
  Rat    36 -----LEGESE------CDRKTSRALEDRNSVTSQEERNEDDEDVE---------DESIYTCDHC 80

  Fly   124 KSSGHEEDAVDAEEPEDLELDDELLSLSGDEDYDDEELQSLDSFYSDMYSTHTSSSYSPSISDGT 188
            :.        |.|...|| .|.......||.| ||.:|..:.|              |||..|
  Rat    81 QQ--------DFESLADL-TDHRAHRCPGDGD-DDPQLSWVAS--------------SPSSKD-- 119

  Fly   189 MTPNSHHLIGAPTAAGQEDHPTEGKINGGADGEDLPKPKRLPHFHHHHHHHYHHQQALKIANKLR 253
                    :.:||.          .|..|.|
  Rat   120 --------VASPTQ----------MIGDGCD---------------------------------- 132

  Fly   254 KINKEAKMGATAGGGATGAASKFDKLTGEGIKSRGDGSYQCQFCEKTFPRLGYLKHHVQSHAEHL 318
                   :|.....|.||.                  .|.||||:|:|.||.|||.|.|.|::.|
  Rat   133 -------LGLGEEEGGTGL------------------PYPCQFCDKSFIRLSYLKRHEQIHSDKL 172

  Fly   319 PFKCEYCSKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNR 383
            ||||.:||:|||||||||||.||||.::.|.|..||||||||||||||:|||...|||:||:|.|
  Rat   173 PFKCTFCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRSDHLKIHLKTHSSSKPFKCSVCKR 237

  Fly   384 GYNTAAALTSHMQKHKKNAAILAAGG-----------------------NPNALNYSPRSTGSAS 425
            |:::.::|.||||.||||...||...                       ..:.|...|:.:..|.
  Rat   238 GFSSTSSLQSHMQAHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEKHVLTLHPQLSEKAD 302

  Fly   426 --------------------------------------ASV--------------SSNGSLQKRR 438
                                                  :||              |||.|:....
  Rat   303 LQCIHCPEVFVDESTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDP 367

  Fly   439 YALALASDSSPSRMDFPKRSRSNHVGGTTTTATPTPL-----------------LRCSYCPKVTE 486
            ...::||.||.:    |..|.|.. .|:|..:|..||                 ..|.||.| .:
  Rat   368 VLGSVASMSSAT----PDSSASVE-RGSTPDSTLKPLRGQKKMRDDGQSWSKVVYSCPYCSK-RD 426

  Fly   487 FSSLEQLNAHLQSVH-EQPQ------------------TQAVKT-------PV-QEGEGFQLSCE 524
            |:||..|..||:::| ::||                  .:.|:.       || |.|......|.
  Rat   427 FTSLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKSHAYPVMQFGNISAFHCN 491

  Fly   525 YCTMKFGNIAGLFQHMRSTHMDRLSSP----NSYY---------------EHFNRL-ATAGTFSP 569
            ||...|.:|..|.:|:|.:|....::|    |:::               ||..:. .:.|:
  Rat   492 YCPEMFADINSLQEHIRVSHCGPNANPPDGNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGS--- 553

  Fly   570 RLALDLPKIKPDLGSPERESRPAEDDLPTDLS----------NNKRRPLTPNPQAQTPLAPPSA- 623
             ..|:.|.|:|.....|..|.|...:.|...|          |:|..||..:.:::...:|.|:
  Rat   554 -TKLESPVIQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAEQSPVSSD 617

  Fly   624 ------------------PPGVFFCNQCNAGLPDFESFRNHLKSHIAEGMQLV-----CPHCGMS 665
                              ..|.:.||||:....:||||:.|||.|    ::|:     ||.|...
  Rat   618 VEVSSPKRQRLSGSANSISNGEYPCNQCDLKFSNFESFQTHLKLH----LELLLRKQACPQCKED 678

  Fly   666 LPEQSEFERHVVGHFLITGSEFNCSSSCGKSFAKSEDLQQHLLSEHVLTLLKCSLCSELCESRMA 730
            ...|....:|:..|::.|.:.:.| .||.|.|:..:|||:|||..|...|..|:||.|:.:|:::
  Rat   679 FDSQESLLQHLTVHYMTTSTHYVC-ESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVS 742

  Fly   731 MQLHLACAHSQETKLLRCSACLELFRSDAEFHVHVKTRHQLGGHPTLGATSSAPTNPLQCMFCRA 795
            :|:|||..||.|.|:.||:||...||.:|:..||||..| ||.          |....:|:||..
  Rat   743 IQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSH-LGN----------PAKAHKCIFCGE 796

  Fly   796 VCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDKEANSPNMGSLYVNALLP 860
            ..|:|:|:..|:..|::::.|..|.:.||...||::|::.:|                   .:..
  Rat   797 TFSTEVELQCHITTHSKKYNCRFCSKAFHAVLLLEKHLREKH-------------------CVFD 842

  Fly   861 PLAAAAAAAAATNNNSSIIDYNVAFKGLFGGASGGAGSGGGGAQSGGAPPSANKFYSPLQVDTNA 925
            |        ||.|..::                             |.||::.|
  Rat   843 P--------AAENGTAN-----------------------------GVPPTSTK----------- 859

  Fly   926 LKAQTSPHPALMYGLSQRYLMEMYAAKSTSPSGNEGVGNSQPPAPQA-TAPPPPPNASTATFSCG 989
             ||:                          |:..:|:....|.||.: .|.....:||...:.|.
  Rat   860 -KAE--------------------------PADLQGMLLKNPEAPNSHEASEDDVDASEPMYGCD 897

  Fly   990 MCERQDLRSEAELHSHRKLAHNLKTGV-------------SLRCAYCAGNFKSRAELEQHMKSCH 1041
            :|... ...|..|.:||...||::.|.             |.:|..|:..|.|...|.:|::: |
  Rat   898 ICGAA-YTMEVLLQNHRLRDHNIRPGEDDGSRKKAEFIKGSHKCNVCSRTFFSENGLREHLQT-H 960

  Fly  1042 NSTGKH-KCLICDEVFPSPAILAEHKLQHSKVGQSGKCSHCGQPLEDVAAFRAHLSEHGSDGASL 1105
            ....|| .|.||.|.|||...|.|||:.|||...:|.|..|..||:....|..|...|.....||
  Rat   961 RGPAKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDLRNSL 1025

  Fly  1106 P-LACICCRQTLHSEFELSLHAKFHTK--------SSSSGGSLQEPV-CALCLEPLP-------- 1152
            . ..|:.|.||:.|..||.:|..||.:        ||.:|..||:.. |||||:...
  Rat  1026 TGFRCVVCMQTVTSTLELKIHGTFHMQKLAGSSAASSPNGQGLQKLYKCALCLKEFRSKQDLVRL 1090

  Fly  1153 DATEGPAKLCDKCCRKHNLNGKRGKHSEP------------------------------------ 1181
            |....|..||..|..: :.||:.|..:.|
  Rat  1091 DVNGLPYGLCAGCMAR-SANGQVGGLAPPEPADRPCAGLRCPECNVKFESAEDLESHMQVDHRDL 1154

  Fly  1182 ----------ATSLPAPPSAF----------------------------VENRCNLCKMILPHAQ 1208
                      |.:.|.|....                            :.:.|.||..:.....
  Rat  1155 TPETSGPRKGAQTSPVPRKKTYQCIKCQMTFENEREIQIHVANHMIEEGINHECKLCNQMFDSPA 1219

  Fly  1209 KLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLNHM-GEHGAHSRPYDCNLCPEKFFFRAELE 1272
            ||..||:||:|.|.... |.|.:|..||.....|..|: ..||...:.|||:.||:||||:.||:
  Rat  1220 KLLCHLIEHSFEGMGGT-FKCPVCFTVFVQANKLQQHIFAVHGQEDKIYDCSQCPQKFFFQTELQ 1283

  Fly  1273 HH 1274
            :|
  Rat  1284 NH 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	13/19 (68%)
		C2H2 Zn finger	322..342	CDD:275368	15/19 (79%)
		zf-H2C2_2	334..359	CDD:290200	16/24 (67%)
		COG5048	336..769	CDD:227381	171/605 (28%)
		zf-C2H2	348..370	CDD:278523	17/21 (81%)
		C2H2 Zn finger	350..370	CDD:275368	16/19 (84%)
		C2H2 Zn finger	378..398	CDD:275368	10/19 (53%)
		C2H2 Zn finger	630..650	CDD:275368	11/19 (58%)
		C2H2 Zn finger	659..679	CDD:275368	5/19 (26%)
		C2H2 Zn finger	689..707	CDD:275368	8/17 (47%)
		C2H2 Zn finger	1020..1041	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1049..1069	CDD:275368	11/19 (58%)
		C2H2 Zn finger	1197..1217	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1229..1246	CDD:275368	5/16 (31%)
		C2H2 Zn finger	1258..1278	CDD:275368	10/17 (59%)
Zfp423	NP_001380647.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		14/47 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..70		11/48 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..123		11/52 (21%)
		C2H2 Zn finger	148..168	CDD:275368	13/19 (68%)
		C2H2 Zn finger	176..196	CDD:275368	15/19 (79%)
		COG5048	202..603	CDD:227381	104/410 (25%)
		C2H2 Zn finger	204..224	CDD:275368	16/19 (84%)
		C2H2 Zn finger	232..252	CDD:275368	10/19 (53%)
		C2H2 Zn finger	273..292	CDD:275368	0/18 (0%)
		C2H2 Zn finger	419..440	CDD:275368	10/21 (48%)
		C2H2 Zn finger	451..475	CDD:275368	1/23 (4%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..635		4/36 (11%)
		C2H2 Zn finger	672..692	CDD:275368	5/19 (26%)
		C2H2 Zn finger	702..723	CDD:275368	11/21 (52%)
		C2H2 Zn finger	730..751	CDD:275368	9/20 (45%)
		C2H2 Zn finger	760..781	CDD:275368	10/20 (50%)
		C2H2 Zn finger	791..811	CDD:275368	7/19 (37%)
		C2H2 Zn finger	817..835	CDD:275368	7/17 (41%)
		C2H2 Zn finger	896..917	CDD:275368	6/21 (29%)
		C2H2 Zn finger	940..960	CDD:275368	6/20 (30%)
		C2H2 Zn finger	969..989	CDD:275368	11/19 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1144..1171		2/26 (8%)
		C2H2 Zn finger	1208..1228	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1239..1260	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1269..1285	CDD:275368	9/15 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10524
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3377
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222002at33208
OrthoFinder	1	1.000	-	-		FOG0002621
OrthoInspector	1	1.000	-	-		otm46374
orthoMCL	1	0.900	-	-		OOG6_106906
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2332
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870