DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and Zfp423

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	XP_011246862.1	Gene:	Zfp423 / 94187	MGIID:	1891217	Length:	1312	Species:	Mus musculus

Alignment Length:	1569	Identity:	402/1569 - (25%)
Similarity:	573/1569 - (36%)	Gaps:	559/1569 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRRKQAKPRACLKLGEKEDEENTGLLEPKEELLSGDEDNE-------DNEGEDEDEEVA--DEV 56
            ||||||||||:               ::....:||.....:       ..|||..|..:|  ..|
Mouse     1 MSRRKQAKPRS---------------VKGARAVLSTSHQFKLYRHLWAVEEGEASDFSLAWDSSV 50

  Fly    57 APEGG-GGERPQLVPNESQQQSWPTADEPAAPA-----AVAKEEEAEEGSEELQHPRDEVVASDA 115
            |..|| .||              |..|...:.|     :|..:||..|..|:::         |.
Mouse    51 AAAGGLEGE--------------PECDRKTSRALEDRNSVTSQEERNEDDEDVE---------DE 92

  Fly   116 AANANGHCKSSGHEEDAVDAEEPEDLELDDELLSLSGDEDYDDEELQSLDSFYSDMYSTHTSSSY 180
            :.....||:.        |.|...|| .|.......||.| ||.:|..:.|
Mouse    93 SIYTCDHCQQ--------DFESLADL-TDHRAHRCPGDGD-DDPQLSWVAS-------------- 133

  Fly   181 SPSISDGTMTPNSHHLIGAPTAAGQEDHPTEGKINGGADGEDLPKPKRLPHFHHHHHHHYHHQQA 245
            |||..|          :.:||.          .|..|.|
Mouse   134 SPSSKD----------VASPTQ----------MIGDGCD-------------------------- 152

  Fly   246 LKIANKLRKINKEAKMGATAGGGATGAASKFDKLTGEGIKSRGDGSYQCQFCEKTFPRLGYLKHH 310
                           :|.....|.||.                  .|.||||:|:|.||.|||.|
Mouse   153 ---------------LGLGEEEGGTGL------------------PYPCQFCDKSFIRLSYLKRH 184

  Fly   311 VQSHAEHLPFKCEYCSKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKP 375
            .|.|::.|||||.:||:|||||||||||.||||.::.|.|..||||||||||||||:|||...||
Mouse   185 EQIHSDKLPFKCTFCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRSDHLKIHLKTHSSSKP 249

  Fly   376 FQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGG-----------------------NPNALNYS 417
            |:||:|.||:::.::|.||||.||||...||...                       ..:.|...
Mouse   250 FKCSVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEKHVLTLH 314

  Fly   418 PRSTGSAS--------------------------------------ASV--------------SS 430
            |:.:..|.                                      :||              ||
Mouse   315 PQLSEKADLQCIHCPEVFVDESTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSS 379

  Fly   431 NGSLQKRRYALALASDSSPSRMDFPKRSRSNHVGGTTTT----------------ATPTPLLRCS 479
            |.|:.......::||.||.:    |..|.|...|.|..:                :.|..:..|.
Mouse   380 NHSVSPDPVLGSVASMSSAT----PDSSASVERGSTPDSTLKPLRGQKKMRDDGQSWPKVVYSCP 440

  Fly   480 YCPKVTEFSSLEQLNAHLQSVH-EQPQ------------------TQAVKT-------PV-QEGE 517
            ||.| .:|:||..|..||:::| ::||                  .:.|:.       || |.|.
Mouse   441 YCSK-RDFTSLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKSHAYPVMQFGN 504

  Fly   518 GFQLSCEYCTMKFGNIAGLFQHMRSTHMDRLSSP----NSYY---------------EHFNRL-A 562
            .....|.||...|.:|..|.:|:|.:|....::|    |:::               ||..:. .
Mouse   505 ISAFHCNYCPEMFADINSLQEHIRVSHCGPNANPPDGNNAFFCNQCSMGFLTESSLTEHIQQAHC 569

  Fly   563 TAGTFSPRLALDLPKIKPDLGSPERESRPAEDDLPTDLS----------NNKRRPLTPNPQAQTP 617
            :.|:    ..|:.|.::|.....|..|.|...:.|...|          |:|..||..:.:::..
Mouse   570 SVGS----TKLESPVVQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAE 630

  Fly   618 LAPPSA-------------------PPGVFFCNQCNAGLPDFESFRNHLKSHIAEGMQLV----- 658
            .:|.|:                   ..|.:.||||:....:||||:.|||.|    ::|:
Mouse   631 QSPVSSDVEVSSPKRQRLSGSANSISNGEYPCNQCDLKFSNFESFQTHLKLH----LELLLRKQA 691

  Fly   659 CPHCGMSLPEQSEFERHVVGHFLITGSEFNCSSSCGKSFAKSEDLQQHLLSEHVLTLLKCSLCSE 723
            ||.|......|....:|:..|::.|.:.:.| .||.|.|:..:|||:|||..|...|..|:||.|
Mouse   692 CPQCKEDFDSQESLLQHLTVHYMTTSTHYVC-ESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQE 755

  Fly   724 LCESRMAMQLHLACAHSQETKLLRCSACLELFRSDAEFHVHVKTRHQLGGHPTLGATSSAPTNPL 788
            :.:|::::|:|||..||.|.|:.||:||...||.:|:..||||..| ||.          |....
Mouse   756 VFDSKVSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSH-LGN----------PAKAH 809

  Fly   789 QCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDKEANSPNMGSL 853
            :|:||....|:|:|:..|:..|::::.|..|.:.||...||::|::.:|
Mouse   810 KCIFCGETFSTEVELQCHITTHSKKYNCRFCSKAFHAVILLEKHLREKH---------------- 858

  Fly   854 YVNALLPPLAAAAAAAAATNNNSSIIDYNVAFKGLFGGASGGAGSGGGGAQSGGAPPSANKFYSP 918
                       ....|||.|..::                             |.||::.|
Mouse   859 -----------CVFDAAAENGTAN-----------------------------GVPPTSTK---- 879

  Fly   919 LQVDTNALKAQTSPHPALMYGLSQRYLMEMYAAKSTSPSGNEGVGNSQPPAPQA-TAPPPPPNAS 982
                    ||:                          |:..:|:....|.||.: .|.....:||
Mouse   880 --------KAE--------------------------PADLQGMLLKNPEAPNSHEASEDDVDAS 910

  Fly   983 TATFSCGMCERQDLRSEAELHSHRKLAHNLKTGV-------------SLRCAYCAGNFKSRAELE 1034
            ...:.|.:|... ...|..|.:||...||::.|.             |.:|..|:..|.|...|.
Mouse   911 EPMYGCDICGAA-YTMEVLLQNHRLRDHNIRPGEDDGSRKKAEFIKGSHKCNVCSRTFFSENGLR 974

  Fly  1035 QHMKSCHNSTGKH-KCLICDEVFPSPAILAEHKLQHSKVGQSGKCSHCGQPLEDVAAFRAHLSEH 1098
            :|::: |....|| .|.||.|.|||...|.|||:.|||...:|.|..|..||:....|..|...|
Mouse   975 EHLQT-HRGPAKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMH 1038

  Fly  1099 GSDGASLP-LACICCRQTLHSEFELSLHAKFHTK--------SSSSGGSLQEPV-CALCLEPLP- 1152
            .....||. ..|:.|.||:.|..||.:|..||.:        ||.:|..||:.. |||||:...
Mouse  1039 PDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKLAGSSAASSPNGQGLQKLYKCALCLKEFRS 1103

  Fly  1153 -------DATEGPAKLCDKCCRKHNLNGKRGKHSEP----------------------------- 1181
                   |....|..||..|..: :.||:.|..:.|
Mouse  1104 KQDLVRLDVNGLPYGLCAGCMAR-SANGQVGGLAPPEPADRPCAGLRCPECNVKFESAEDLESHM 1167

  Fly  1182 -----------------ATSLPAPPSAF----------------------------VENRCNLCK 1201
                             |.:.|.|....                            :.:.|.||.
Mouse  1168 QVDHRDLTPETSGPRKGAQTSPVPRKKTYQCIKCQMTFENEREIQIHVANHMIEEGINHECKLCN 1232

  Fly  1202 MILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLNHM-GEHGAHSRPYDCNLCPEKF 1265
            .:.....||..||:||:|.|.... |.|.:|..||.....|..|: ..||...:.|||:.||:||
Mouse  1233 QMFDSPAKLLCHLIEHSFEGMGGT-FKCPVCFTVFVQANKLQQHIFAVHGQEDKIYDCSQCPQKF 1296

  Fly  1266 FFRAELEHH 1274
            ||:.||::|
Mouse  1297 FFQTELQNH 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	13/19 (68%)
		C2H2 Zn finger	322..342	CDD:275368	15/19 (79%)
		zf-H2C2_2	334..359	CDD:290200	16/24 (67%)
		COG5048	336..769	CDD:227381	168/604 (28%)
		zf-C2H2	348..370	CDD:278523	17/21 (81%)
		C2H2 Zn finger	350..370	CDD:275368	16/19 (84%)
		C2H2 Zn finger	378..398	CDD:275368	10/19 (53%)
		C2H2 Zn finger	630..650	CDD:275368	11/19 (58%)
		C2H2 Zn finger	659..679	CDD:275368	5/19 (26%)
		C2H2 Zn finger	689..707	CDD:275368	8/17 (47%)
		C2H2 Zn finger	1020..1041	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1049..1069	CDD:275368	11/19 (58%)
		C2H2 Zn finger	1197..1217	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1229..1246	CDD:275368	5/16 (31%)
		C2H2 Zn finger	1258..1278	CDD:275368	10/17 (59%)
Zfp423	XP_011246862.1	C2H2 Zn finger	168..188	CDD:275368	13/19 (68%)
		C2H2 Zn finger	196..216	CDD:275368	15/19 (79%)
		COG5048	222..623	CDD:227381	101/409 (25%)
		C2H2 Zn finger	224..244	CDD:275368	16/19 (84%)
		C2H2 Zn finger	252..272	CDD:275368	10/19 (53%)
		C2H2 Zn finger	293..312	CDD:275368	0/18 (0%)
		C2H2 Zn finger	439..460	CDD:275368	10/21 (48%)
		C2H2 Zn finger	471..495	CDD:275368	1/23 (4%)
		C2H2 Zn finger	510..529	CDD:275368	7/18 (39%)
		C2H2 Zn finger	692..712	CDD:275368	5/19 (26%)
		C2H2 Zn finger	722..743	CDD:275368	11/21 (52%)
		C2H2 Zn finger	750..771	CDD:275368	9/20 (45%)
		C2H2 Zn finger	780..801	CDD:275368	10/20 (50%)
		C2H2 Zn finger	811..831	CDD:275368	7/19 (37%)
		C2H2 Zn finger	837..855	CDD:275368	7/17 (41%)
		C2H2 Zn finger	916..937	CDD:275368	6/21 (29%)
		C2H2 Zn finger	960..980	CDD:275368	6/20 (30%)
		C2H2 Zn finger	989..1009	CDD:275368	11/19 (58%)
		C2H2 Zn finger	1228..1248	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1259..1280	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1289..1305	CDD:275368	9/15 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10746
eggNOG	1	0.900	-	-		E33208_3BE22
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3252
Isobase	1	0.950	-	0	Normalized mean entropy	S5997
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002621
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106906
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4838
SonicParanoid	1	1.000	-	-		X2332
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.700