DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and Zxdc

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_766590.1	Gene:	Zxdc / 80292	MGIID:	1933108	Length:	858	Species:	Mus musculus

Alignment Length:	1223	Identity:	221/1223 - (18%)
Similarity:	318/1223 - (26%)	Gaps:	572/1223 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLSGDEDNEDNEGEDEDEEVADEVAPEGGGGERPQLVPNESQQQSWPTADEPAAPAAVAKEEEAE 97
            ||.|.||                    ||.|.||:..|..|          |..|         |
Mouse    43 LLRGPED--------------------GGPGPRPEEAPGPS----------PPPP---------E 68

  Fly    98 EGSEE----LQHPRDEVVASDAAANANGHCKSSGHEEDAVDAEEPEDLELDDELLSLSGDEDYDD 158
            :|.:.    |:.||    |:|..........|.....:.|.|..|.        .:|:|.....:
Mouse    69 DGGDSFVVLLEVPR----AADTHGQEEAEPDSGASPTEQVPAAAPG--------AALAGTVTIHN 121

  Fly   159 EELQSLDSFYSDMYSTHTSSSYSPSISDGTMTPNSHHLIGAPTAAGQEDHPTEGKINGGADGEDL 223
            ::|  |..|...:::                      |..||..|....||
Mouse   122 QDL--LVRFDRGVFT----------------------LAAAPAPAAPSLHP-------------- 148

  Fly   224 PKPKRLPHFHHHHHHHYHHQQALKIANKLRKINKEAKMGATAGG--GATGAASKFDKLTGEGIKS 286
                                                   ||..|  .::.|||:    .|....|
Mouse   149 ---------------------------------------ATTPGLEPSSAAASR----RGPVAAS 170

  Fly   287 RGDGSYQC--QFCEKTFPRLGYLKHHVQSHAE---HLPFKC--EYCSKLFKHKRSRDRHKKLHTN 344
            .|..:|:|  ..|..:|.:...||.|:.:|..   ..||||  :.|...|.......||.:.|..
Mouse   171 AGSPAYRCPEPQCALSFAKKHQLKVHLLTHGSLQGRRPFKCPLDGCGWAFTTSYKLKRHLQSHDK 235

  Fly   345 ERNYKCP--HCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAA 407
            .|.:.||  .|...|:...:||.|||.|:.:..|:|.:|...:.|.|.|.||.:.|
Mouse   236 LRPFSCPVGGCGKKFTTVYNLKAHMKGHEQESLFKCEVCAERFPTHAKLNSHQRSH--------- 291

  Fly   408 GGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRMDFPKRSRSNHVGGTTTTATP 472
                    :.|                            ..|.:.|||.
Mouse   292 --------FEP----------------------------ERPYKCDFPG---------------- 304

  Fly   473 TPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQTQAVKTPVQEGEGFQLSCEYCTMKFGNIAGLF 537
                                                                 |...|..::.||
Mouse   305 -----------------------------------------------------CEKTFITVSALF 316

  Fly   538 QHMRSTHMDRLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDLGSPERESRPAEDDLPTDLSN 602
            .|.|:              ||.                          |:|
Mouse   317 SHNRA--------------HFR--------------------------EQE-------------- 327

  Fly   603 NKRRPLTPNPQAQTPLAPPSAPPGVFFCN--QCNAGLPDFESFRNHLKSHIAEGMQLVC--PHCG 663
                                    :|.|:  .||.........:.||:||..| ...:|  ..||
Mouse   328 ------------------------LFSCSFPGCNKQYDKACRLKIHLRSHTGE-RPFICDSDSCG 367

  Fly   664 MSLPEQSEFERHVVGHFLITGSEFNCS-SSCGKSFAKSEDLQQHLLSEHVLTLLKCSLCSELCES 727
            .:....|:..||...|  .....|.|. ..|||||.::|.|:.|.::
Mouse   368 WTFTSMSKLLRHKRKH--DDDRRFTCPVEGCGKSFTRAEHLKGHSIT------------------ 412

  Fly   728 RMAMQLHLACAHSQETKLLRC--SACLELFRSDAEFHVHVKTRHQLGGHPTLGATSSAPTNPLQC 790
                  ||.      ||...|  ..|...|.:.:..::|.|...|..|.|
Mouse   413 ------HLG------TKPFECPVEGCCARFSARSSLYIHSKKHLQDVGTP--------------- 450

  Fly   791 MFCRAVCSSELEMHFHLAAHARQFRCP--SCPETFHVEFLLDRHMQSQHGGVKD----------- 842
                                  :.|||  ||...|..:..:..|:..||...:|
Mouse   451 ----------------------KSRCPVSSCNRLFTSKHSMKAHVVRQHSRRQDLVPQLEAPSSL 493

  Fly   843 ---KEANSPNMGSLY---VNALLPPLAAAAAAAAATNN---NSSIIDYNVAFKGLFGGASGGAGS 898
               .|.:||....|.   :.||.....|.::::.|.::   ||.|:..:|         :..:.|
Mouse   494 TPSSELSSPGQSELTNIDLAALFSDTPANSSSSTAGSDEALNSGILTIDV---------TSVSSS 549

  Fly   899 GGGGAQS----------------GGAPPSANKFYSPLQVDTNALKAQTSPHPALMYGLSQRYLME 947
            .||...:                |..|||.:   |||.:.|:|...|.....|           :
Mouse   550 LGGNLPTNNNSLGPMDPLVLVAHGDMPPSLD---SPLVLGTSATVLQPGSFSA-----------D 600

  Fly   948 MYAAKSTSPSG------NEGVGNSQP---PAPQATAPPPPPNASTATFSCGMCE--------RQD 995
            ...|.||...|      ...:....|   |:...|||...|.:|..|...|...        .||
Mouse   601 DSQAMSTGAVGCLVALPVRNLNQDSPALTPSNNLTAPGTTPTSSDTTQETGSVPDLLVPIKVEQD 665

  Fly   996 LRSEAELHSHRKLAHN-----------------------------LKTGVSLRCAYCA------- 1024
            |....::...:|.:|.                             |::|.|.|..|.|
Mouse   666 LSPVPDVVQGQKESHGPSQSVLSSSTERPGAQKDSELSAGTGSLYLESGGSARTDYRAIQLVKKK 730

  Fly  1025 -----GNFKSRAELEQHMK-------SCHNSTGKHKCLICDEVFPS-----PAILAEHKLQHSKV 1072
                 |:.:..:: ..|.|       ..|..:|:|.|.....:.||     ||..|  .||
Mouse   731 KQKGTGSDEGASD-SAHRKVKGGTINPPHVHSGQHSCFCGTLMVPSGGLTVPAPAA--GLQ---- 788

  Fly  1073 GQSGKCSHCGQ-PLEDVAAFRAHLSEHGSDGASLPLACICCRQTLHSEFELSL 1124
                    |.| |:         |.:..|....|||.....|...|..|.:.|
Mouse   789 --------CVQIPV---------LQDDPSGEGGLPLGLSPQRSAFHPYFTVDL 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	6/21 (29%)
		C2H2 Zn finger	322..342	CDD:275368	5/21 (24%)
		zf-H2C2_2	334..359	CDD:290200	8/26 (31%)
		COG5048	336..769	CDD:227381	73/441 (17%)
		zf-C2H2	348..370	CDD:278523	9/23 (39%)
		C2H2 Zn finger	350..370	CDD:275368	9/21 (43%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	630..650	CDD:275368	5/21 (24%)
		C2H2 Zn finger	659..679	CDD:275368	6/21 (29%)
		C2H2 Zn finger	689..707	CDD:275368	8/18 (44%)
		C2H2 Zn finger	1020..1041	CDD:275368	5/39 (13%)
		C2H2 Zn finger	1049..1069	CDD:275368	7/24 (29%)
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
Zxdc	NP_766590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73		16/68 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..108		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..175		12/89 (13%)
		C2H2 Zn finger	178..200	CDD:275368	6/21 (29%)
		zf-C2H2_aberr	209..354	CDD:293622	50/336 (15%)
		C2H2 Zn finger	211..233	CDD:275368	5/21 (24%)
		zf-H2C2_2	226..252	CDD:290200	8/25 (32%)
		C2H2 Zn finger	241..263	CDD:275368	9/21 (43%)
		C2H2 Zn finger	271..291	CDD:275368	7/19 (37%)
		C2H2 Zn finger	300..322	CDD:275368	9/104 (9%)
		C2H2 Zn finger	334..353	CDD:275368	4/18 (22%)
		C2H2 Zn finger	361..383	CDD:275368	6/21 (29%)
		zf-H2C2_2	376..402	CDD:290200	10/27 (37%)
		C2H2 Zn finger	391..413	CDD:275368	9/45 (20%)
		COG5048	392..>691	CDD:227381	74/388 (19%)
		C2H2 Zn finger	421..443	CDD:275368	5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..652		8/27 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..714		3/42 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	727..751		3/24 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46179
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100