DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and ZXDC

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_079388.3	Gene:	ZXDC / 79364	HGNCID:	28160	Length:	858	Species:	Homo sapiens

Alignment Length:	1043	Identity:	197/1043 - (18%)
Similarity:	293/1043 - (28%)	Gaps:	432/1043 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 YKC--PHCEAAFSRSDHLKIHMKTH---DIQKPFQCSM--CNRGYNTAAALTSHMQKHKKNAAIL 405
            |:|  |.|..||::...||:|:.||   ..::||:|.:  |...:.|:..|..|:|.|.|    |
Human   175 YRCPEPQCALAFAKKHQLKVHLLTHGGGQGRRPFKCPLEGCGWAFTTSYKLKRHLQSHDK----L 235

  Fly   406 AAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRMDFPKRSRSNHVGGTTTTA 470
            ...|.|                                                   |||
Human   236 RPFGCP---------------------------------------------------VGG----- 244

  Fly   471 TPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQTQAVKTPVQEGEGFQLSCEYCTMKFGNIAG 535
                      |.|  :|:::..|.||::. |||...              ..||.|..:|...|.
Human   245 ----------CGK--KFTTVYNLKAHMKG-HEQESL--------------FKCEVCAERFPTHAK 282

  Fly   536 LFQHMRSTHMDRLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDLGSPERESRPAEDDLP--- 597
            |..|.||              ||                         .||   ||.:.|.|
Human   283 LSSHQRS--------------HF-------------------------EPE---RPYKCDFPGCE 305

  Fly   598 ------TDLSNNKRRPLTPNPQAQTPLAPPSAPPGVFFCN--QCNAGLPDFESFRNHLKSHIAEG 654
                  :.|.::.|.......              :|.|:  .|:.........:.||:||..|
Human   306 KTFITVSALFSHNRAHFREQE--------------LFSCSFPGCSKQYDKACRLKIHLRSHTGE- 355

  Fly   655 MQLVC--PHCGMSLPEQSEFERHVVGHFLITGSEFNCS-SSCGKSFAKSEDLQQHLLSEHVLTLL 716
            ...:|  ..||.:....|:..||...|  .....|.|. ..|||||.::|.|:.|.::
Human   356 RPFICDSDSCGWTFTSMSKLLRHRRKH--DDDRRFTCPVEGCGKSFTRAEHLKGHSIT------- 411

  Fly   717 KCSLCSELCESRMAMQLHLACAHSQETKLLRC--SACLELFRSDAEFHVHVKTRHQLGGHPTLGA 779
                             ||.      ||...|  ..|...|.:.:..::|.|...|     .:||
Human   412 -----------------HLG------TKPFECPVEGCCARFSARSSLYIHSKKHVQ-----DVGA 448

  Fly   780 TSSAPTNPLQCMFCRAVCSSELEMHFHLAAHARQFRCP--SCPETFHVEFLLDRHMQSQHGGVKD 842
            ..|                                |||  :|...|..:..:..||..||...:|
Human   449 PKS--------------------------------RCPVSTCNRLFTSKHSMKAHMVRQHSRRQD 481

  Fly   843 KEANSPNMGSLYVNALLPPLAAAAAAAAATNNNS------SIIDYNVAFKGLFGGASGGAGSGGG 901
                           |||.|.|.::...::..:|      :.:|....|......|||.||....
Human   482 ---------------LLPQLEAPSSLTPSSELSSPGQSELTNMDLAALFSDTPANASGSAGGSDE 531

  Fly   902 GAQSGGAPPSANKFYSPLQVDTNALKAQTSPHPALMYGLSQRYLMEMYAAKSTSPSGNEGVGNSQ 966
            ...||           .|.:|..::.:...                     ...|:.|..:|..:
Human   532 ALNSG-----------ILTIDVTSVSSSLG---------------------GNLPANNSSLGPME 564

  Fly   967 PPAPQATAPPPPP--------NASTA------------TFSCGM--C----ERQDLRSE-AELHS 1004
            |....|.:..||.        .|:|.            |.|.|.  |    ..::|..: ..|.|
Human   565 PLVLVAHSDIPPSLDSPLVLGTAATVLQQGSFSVDDVQTVSAGALGCLVALPMKNLSDDPLALTS 629

  Fly  1005 HRKLAHNLKTGVSLRCAYCAGNFKSRAELEQHMKSCHNSTGKHKCLICDEVFPSPAILAEHKLQH 1069
            :..||.::.|..|                        :||.:....:       |.:||..|::.
Human   630 NSNLAAHITTPTS------------------------SSTPRENASV-------PELLAPIKVEP 663

  Fly  1070 SKVGQSGKCSHCGQPLEDVAAFRAHLSEHGSDGASLPLACICCRQTLHSEFELSLHAKFHTKSSS 1134
            ....:.|.   .||             :.||.|  ||.:.:......|...:..|.|........
Human   664 DSPSRPGA---VGQ-------------QEGSHG--LPQSTLPSPAEQHGAQDTELSAGTGNFYLE 710

  Fly  1135 SGGSLQEPVCALCLEPLPDATEGPAKLCDKCCRKHNLNGKRGKHSEPATSLPAPPSAFVENRCNL 1199
            ||||.:....|:.|     |.|               ..:||..|.      |..|...:.:...
Human   711 SGGSARTDYRAIQL-----AKE---------------KKQRGAGSN------AGASQSTQRKIKE 749

  Fly  1200 CKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPGGLLNHMGEHGAHSRPYDCNLCPEK 1264
            .||..||....|                |.::|.::....||........|..        |..:
Human   750 GKMSPPHFHASQ----------------NSWLCGSLVVPSGGRPGPAPAAGVQ--------CGAQ 790

  Fly  1265 FFFRAELEHHQRGHELRPQARPPAAKVEVPSIRNTSPGQSPVRSPTIVKQELYETDTVESAGVED 1329
            ......::....|..:.|.||.||  ..:|.:        .|..|..|.||:     :.|:|...
Human   791 GVQVQLVQDDPSGEGVLPSARGPA--TFLPFL--------TVDLPVYVLQEV-----LPSSGGPA 840

  Fly  1330 EPE 1332
            .||
Human   841 GPE 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	322..342	CDD:275368
		zf-H2C2_2	334..359	CDD:290200	6/12 (50%)
		COG5048	336..769	CDD:227381	89/443 (20%)
		zf-C2H2	348..370	CDD:278523	9/23 (39%)
		C2H2 Zn finger	350..370	CDD:275368	8/21 (38%)
		C2H2 Zn finger	378..398	CDD:275368	6/21 (29%)
		C2H2 Zn finger	630..650	CDD:275368	4/21 (19%)
		C2H2 Zn finger	659..679	CDD:275368	6/21 (29%)
		C2H2 Zn finger	689..707	CDD:275368	8/18 (44%)
		C2H2 Zn finger	1020..1041	CDD:275368	0/20 (0%)
		C2H2 Zn finger	1049..1069	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1197..1217	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1229..1246	CDD:275368	3/16 (19%)
		C2H2 Zn finger	1258..1278	CDD:275368	1/19 (5%)
ZXDC	NP_079388.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..174
		C2H2 Zn finger	177..199	CDD:275368	8/21 (38%)
		zf-C2H2_aberr	208..353	CDD:293622	49/287 (17%)
		zf-C2H2	208..232	CDD:278523	7/23 (30%)
		C2H2 Zn finger	210..232	CDD:275368	6/21 (29%)
		C2H2 Zn finger	240..262	CDD:275368	10/90 (11%)
		C2H2 Zn finger	270..290	CDD:275368	9/33 (27%)
		COG5048	<284..443	CDD:227381	47/247 (19%)
		C2H2 Zn finger	299..321	CDD:275368	4/21 (19%)
		C2H2 Zn finger	333..352	CDD:275368	3/18 (17%)
		C2H2 Zn finger	360..382	CDD:275368	6/21 (29%)
		zf-H2C2_2	375..401	CDD:290200	10/27 (37%)
		C2H2 Zn finger	390..412	CDD:275368	9/45 (20%)
		COG5048	391..>584	CDD:227381	55/306 (18%)
		C2H2 Zn finger	420..442	CDD:275368	5/21 (24%)
		Required for transcriptional activation	579..688		27/157 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..696		10/53 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..756		8/50 (16%)
		Interaction with CIITA	781..858		18/86 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..858		3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46179
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100