DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and ZXDA

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_009087.1	Gene:	ZXDA / 7789	HGNCID:	13198	Length:	799	Species:	Homo sapiens

Alignment Length:	1036	Identity:	202/1036 - (19%)
Similarity:	301/1036 - (29%)	Gaps:	393/1036 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GEKEDEENTGLLEPKEELLSGDEDNEDNEGEDEDEEVADEVAPEGGGGERPQLVPNESQQQSWPT 80
            |.:.:|.:|....|...|.:.........|:|....:.|   |.||..|               |
Human    56 GRRREEASTASRGPGPSLFAPRPHQPSGGGDDFFLVLLD---PVGGDVE---------------T 102

  Fly    81 ADEPAAPAAVAKEE-EAEEGSEELQHPRDEVVASDAAANANG-HCKSSGHEEDAVDAEEPEDLEL 143
            |....|...|.:|| :|..|.:     .||..|:.|..:|.| ||.|:        ...|..:..
Human   103 AGSGQAAGPVLREEAKAGPGLQ-----GDESGANPAGCSAQGPHCLSA--------VPTPAPISA 154

  Fly   144 DDELLSLSGDEDYDDEELQSLDSFYSDM--YSTHTSSSYSPSISDGTMTPNSHHLIGAPTAA-GQ 205
            .....:.:|.....:::|  |..|.:.:  .:|....::.|    |.........:.||.|. .|
Human   155 PGPAAAFAGTVTIHNQDL--LLRFENGVLTLATPPPHAWEP----GAAPAQQPRCLIAPQAGFPQ 213

  Fly   206 EDHPTEGKINGGADGEDL-----------PKPKRLPHFHHHHHHHYHHQQALKIANKLRKINKEA 259
            ..||        .|..:|           |.|...|                          :|.
Human   214 AAHP--------GDCPELRSDLLLAEPAEPAPAPAP--------------------------QEE 244

  Fly   260 KMGATAGGGATGAASKFDKLTGEGIKSRGDGSYQC--QFCEKTFPRLGYLKHHVQSHAE---HLP 319
            ..|..|..|..|       |.|.|   .|...|.|  ..|.:||.:...||.|:.:|:.   ..|
Human   245 AEGLAAALGPRG-------LLGSG---PGVVLYLCPEALCGQTFAKKHQLKMHLLTHSSSQGQRP 299

  Fly   320 FKCEY--CSKLFKHKRSRDRHKKLHTNERNYKCP--HCEAAFSRSDHLKIHMKTHDIQKPFQCSM 380
            |||..  |...|.......||.:.|...|.:.||  .|..:|:...:||.|||.|:.:..|:|.:
Human   300 FKCPLGGCGWTFTTSYKLKRHLQSHDKLRPFGCPAEGCGKSFTTVYNLKAHMKGHEQENSFKCEV 364

  Fly   381 CNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALAS 445
            |...:.|.|.|.:|.:.|                 :.|
Human   365 CEESFPTQAKLGAHQRSH-----------------FEP--------------------------- 385

  Fly   446 DSSPSRMDFPKRSRSNHVGGTTTTATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQTQAVK 510
                                                                    |:|
Human   386 --------------------------------------------------------ERP------ 388

  Fly   511 TPVQEGEGFQLSCEYCTMKFGNIAGLFQHMRSTHMDRLSSPNSYYEHFNRLATAGTFSPRLALDL 575
                    :|.:...|...|..::.||.|.|:              ||.
Human   389 --------YQCAFSGCKKTFITVSALFSHNRA--------------HFR---------------- 415

  Fly   576 PKIKPDLGSPERESRPAEDDLPTDLSNNKRRPLTPNPQAQTPLAPPSAPPGVFFCN--QCNAGLP 638
                      |:|                                      :|.|:  .|:....
Human   416 ----------EQE--------------------------------------LFSCSFPGCSKQYD 432

  Fly   639 DFESFRNHLKSHIAEGMQLVCPH--CGMSLPEQSEFERHVVGHFLITGSEFNCS-SSCGKSFAKS 700
            .....:.||:||..| ...:|..  ||.:....|:..||...|  .....|.|. ..|||||.::
Human   433 KACRLKIHLRSHTGE-RPFLCDFDGCGWNFTSMSKLLRHKRKH--DDDRRFMCPVEGCGKSFTRA 494

  Fly   701 EDLQQHLLSEHVLTLLKCSL--CSELCESRMAMQLHLACAHSQ--ETKLLRC--SACLELFRSDA 759
            |.|:.|.::........|.:  |.....:|.::.:| :..|.|  :|...||  |:|.:||.|..
Human   495 EHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIH-SKKHLQDVDTWKSRCPISSCNKLFTSKH 558

  Fly   760 EFHVHVKTRHQLGGHPTLGATSSAPTNPLQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFH 824
            ....|:..||::|........::....|          ||||       ...||
Human   559 SMKTHMVKRHKVGQDLLAQLEAANSLTP----------SSEL-------TSQRQ----------- 595

  Fly   825 VEFLLDRHMQSQHGGVKDKEANS------PNMGSLYVNALLPPLAAAAAAAAATNNNSSIIDYNV 883
             ..|.|..:.|....|.|..:.:      .|.|.|.::  :..:::..|.....|||:|:
Human   596 -NDLSDAEIVSLFSDVPDSTSAALLDTALVNSGILTID--VASVSSTLAGHLPANNNNSV----- 652

  Fly   884 AFKGLFGGASGGAGSGGGGAQSGGAPPSANKFYSPLQ-VDTNALKAQTSPHPALMYGLSQRYL-M 946
                             |.|..   |||......|.| :||:......:.      |..|..| |
Human   653 -----------------GQAVD---PPSLMATSDPPQSLDTSLFFGTAAT------GFQQSSLNM 691

  Fly   947 EMYAAKSTSPSG---NEGVGNSQPPAPQATAPPPPPNASTATF--SCGMCERQDLRSEAEL 1002
            :..::.|..|.|   :..:.||. |.|||..|.......|.|.  |..:||    .|.:||
Human   692 DEVSSVSVGPLGSLDSLAMKNSS-PEPQALTPSSKLTVDTDTLTPSSTLCE----NSVSEL 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	7/21 (33%)
		C2H2 Zn finger	322..342	CDD:275368	5/21 (24%)
		zf-H2C2_2	334..359	CDD:290200	8/26 (31%)
		COG5048	336..769	CDD:227381	76/445 (17%)
		zf-C2H2	348..370	CDD:278523	9/23 (39%)
		C2H2 Zn finger	350..370	CDD:275368	9/21 (43%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		C2H2 Zn finger	630..650	CDD:275368	4/21 (19%)
		C2H2 Zn finger	659..679	CDD:275368	6/21 (29%)
		C2H2 Zn finger	689..707	CDD:275368	8/18 (44%)
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
ZXDA	NP_009087.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..89		7/32 (22%)
		Required for interaction with ZXDC. /evidence=ECO:0000269\|PubMed:17493635	267..573		94/501 (19%)
		C2H2 Zn finger	269..291	CDD:275368	7/21 (33%)
		zf-C2H2_aberr	300..445	CDD:293622	47/336 (14%)
		zf-C2H2	300..324	CDD:278523	7/23 (30%)
		C2H2 Zn finger	302..324	CDD:275368	5/21 (24%)
		C2H2 Zn finger	332..354	CDD:275368	9/21 (43%)
		zf-H2C2_2	346..369	CDD:290200	9/22 (41%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..413	CDD:275368	6/35 (17%)
		C2H2 Zn finger	425..444	CDD:275368	3/18 (17%)
		COG5048	<437..568	CDD:227381	37/134 (28%)
		C2H2 Zn finger	452..474	CDD:275368	6/21 (29%)
		zf-H2C2_2	467..493	CDD:290200	10/27 (37%)
		C2H2 Zn finger	482..504	CDD:275368	9/21 (43%)
		C2H2 Zn finger	512..534	CDD:275370	4/22 (18%)
		Required for transcriptional activation	572..699		33/188 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46179
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100