DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oaz and Zxdb

DIOPT Version :9

Sequence 1:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster
Sequence 2:	NP_001074942.1	Gene:	Zxdb / 668166	MGIID:	3694898	Length:	873	Species:	Mus musculus

Alignment Length:	1062	Identity:	204/1062 - (19%)
Similarity:	292/1062 - (27%)	Gaps:	435/1062 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLEPKEELLSGDEDNEDNEGEDEDEEVADEVAPEGGGGERPQLVPNESQQQSWPTADEP------ 84
            ||:|    :.||.:....|     :..|.....|.|.|.||     |.:|.:.|.|..|
Mouse   130 LLDP----VGGDVETVGTE-----QAGAPVRREEAGAGPRP-----ERRQSAGPPAGRPEPGPRC 180

  Fly    85 --AAPAAVAKEEEAEEGSEELQHPRDEVVASDAAANANGHCKSSGHEEDAVDAEEPEDLELDDEL 147
              |.||| :....|..|      |.....|:.|||.|.   ..:.|.:|.:       |..::.:
Mouse   181 LSAVPAA-SPLPAAGPG------PAAAAAAAAAAAFAG---TITIHNQDLL-------LRFENGV 228

  Fly   148 LSLSGDEDYDDEELQSLDSFYSDMYSTHTSSSYSPSIS---DGTMTPNSHHLIGAPTAAGQEDHP 209
            |:|                      :|....::.|.::   .....|....|| ||.||.....|
Mouse   229 LTL----------------------TTPPLPAWEPGVAPFPQPQPPPQPGALI-APQAAAAGFPP 270

  Fly   210 ----TEGKINGGADGEDLPKPKRLPHFHHHHHHHYHHQQALKIANKLRKINKEAKMGATAGGGAT 270
                .......||...|.|:   ||             ..|.:|.........|.....|...|.
Mouse   271 AAAAAAAAAAAGAQLGDCPE---LP-------------PDLLLAEPAEPAACPAPPEEEAEAPAA 319

  Fly   271 GAASKFDKLTGEGIKSRGDG--SYQC--QFCEKTFPRLGYLKHHVQSHAE---HLPFKCEY--CS 326
            .||.......|.|   .|.|  .|.|  ..|.:||.:...||.|:.:|:.   ..||||..  |.
Mouse   320 AAAQSPRGPAGPG---PGPGVVLYLCPEAQCGQTFAKKHQLKVHLLTHSSSQGQRPFKCPLSGCG 381

  Fly   327 KLFKHKRSRDRHKKLHTNERNYKCP--HCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAA 389
            ..|.......||.:.|...|.:.||  .|..:|:...:||.|||.|:.:..|:|.:|...:.|.|
Mouse   382 WTFTTSYKLKRHLQSHDKLRPFGCPVQGCGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQA 446

  Fly   390 ALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRMDF 454
            .|::|.:.|                 :.|
Mouse   447 KLSTHQRSH-----------------FEP------------------------------------ 458

  Fly   455 PKRSRSNHVGGTTTTATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQTQAVKTPVQEGEGF 519
                                                           |:|              :
Mouse   459 -----------------------------------------------ERP--------------Y 462

  Fly   520 QLSCEYCTMKFGNIAGLFQHMRSTHMDRLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDLGS 584
            |.:...|...|..::.||.|.|:              ||.
Mouse   463 QCAFSGCKKTFITVSALFSHNRA--------------HFR------------------------- 488

  Fly   585 PERESRPAEDDLPTDLSNNKRRPLTPNPQAQTPLAPPSAPPGVFFCN--QCNAGLPDFESFRNHL 647
             |:|                                      :|.|:  .|:.........:.||
Mouse   489 -EQE--------------------------------------LFACSFPGCSKQYDKACRLKIHL 514

  Fly   648 KSHIAEGMQLVCPH--CGMSLPEQSEFERHVVGHFLITGSEFNCS-SSCGKSFAKSEDLQQHLLS 709
            :||..| ...:|..  ||.:....|:..||...|  .....|.|. ..|||||.::|.|:.|.::
Mouse   515 RSHTGE-RPFLCDFDGCGWNFTSMSKLLRHKRKH--EDDRRFTCPVEGCGKSFTRAEHLKGHSIT 576

  Fly   710 EHVLTLLKCSLCSELCESRMAMQLHLACAHSQETKLLRC--SACLELFRSDAEFHVHVKTRHQLG 772
                                    ||.      ||...|  ..|...|.:.:..::|.|...|
Mouse   577 ------------------------HLG------TKPFVCPVEGCCARFSARSSLYIHSKKHLQ-- 609

  Fly   773 GHPTLGATSSAPTNPLQCMFCRAVCSSELEMHFHLAAHARQFRC--PSCPETFHVEFLLDRHMQS 835
               .:||..|                                ||  |:|.:.|..:..:..||..
Mouse   610 ---DVGAWKS--------------------------------RCPVPTCNKLFTSKHSMKTHMTK 639

  Fly   836 QHGGVKD--------------KEANSPNMGSLYVNALLP-----PLAAAAAAAAATNNNSSIIDY 881
            :|...:|              .|..||....|....|:.     |...:||.......||.|:..
Mouse   640 RHNLSQDLLAQLEAANSLTPSSELTSPGQSDLSGAELVSLFSDVPGHGSAAVLDTALVNSGILTI 704

  Fly   882 NVAFKGLFGGASGGAGSGGGGAQSGGAPPSANKFYSPL--QVDTNALKAQTSPHP-----ALMYG 939
            :||              ....:.:|..|...|.....|  ..:..||:...|..|     :|.:|
Mouse   705 DVA--------------SVNSSLAGSLPADNNSNNHSLGQAAEPRALRGAPSDLPQSLDTSLFFG 755

  Fly   940 LSQRYLMEMYAAKSTSP-------SGNEGVGNS-----QPPAPQATAPPPPPNAST--ATFSCGM 990
            .|       .|....||       :||.|:..|     ....|||..|.......|  .|.|..:
Mouse   756 TS-------VAGYQHSPLDMDDVSAGNVGLFGSLALKNSSLEPQALTPSNKLTVDTEALTPSSTL 813

  Fly   991 CERQDLRSEAELHSHRKLAHNL 1012
            ||    .|.:||.:..|...|:
Mouse   814 CE----NSVSELLTPAKAEWNV 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	7/21 (33%)
		C2H2 Zn finger	322..342	CDD:275368	5/21 (24%)
		zf-H2C2_2	334..359	CDD:290200	8/26 (31%)
		COG5048	336..769	CDD:227381	70/441 (16%)
		zf-C2H2	348..370	CDD:278523	9/23 (39%)
		C2H2 Zn finger	350..370	CDD:275368	9/21 (43%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		C2H2 Zn finger	630..650	CDD:275368	4/21 (19%)
		C2H2 Zn finger	659..679	CDD:275368	6/21 (29%)
		C2H2 Zn finger	689..707	CDD:275368	8/18 (44%)
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
Zxdb	NP_001074942.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..120
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..184		12/55 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..259		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..330		5/28 (18%)
		Required for interaction with ZXDC. /evidence=ECO:0000250	340..646		97/567 (17%)
		C2H2 Zn finger	342..364	CDD:275368	7/21 (33%)
		zf-C2H2_aberr	373..518	CDD:293622	47/336 (14%)
		C2H2 Zn finger	375..397	CDD:275368	5/21 (24%)
		C2H2 Zn finger	405..427	CDD:275368	9/21 (43%)
		zf-H2C2_2	419..442	CDD:290200	9/22 (41%)
		C2H2 Zn finger	435..455	CDD:275368	6/19 (32%)
		C2H2 Zn finger	464..486	CDD:275368	6/35 (17%)
		C2H2 Zn finger	498..517	CDD:275368	3/18 (17%)
		COG5048	<510..642	CDD:227381	42/201 (21%)
		C2H2 Zn finger	525..547	CDD:275368	6/21 (29%)
		C2H2 Zn finger	555..577	CDD:275368	9/45 (20%)
		C2H2 Zn finger	585..607	CDD:275370	5/21 (24%)
		Required for transcriptional activation. /evidence=ECO:0000250	645..776		29/151 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46179
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100